Nanomedical Devices and Cancer Theranostics

Abstract

The current therapies against cancer showed limited success. Nanotechnology is a promising strategy for cancer tracking, diagnosis, and therapy. The hybrid nanotechnology assembled several materials in a multimodal system to develop multifunctional approaches to cancer treatment. The quantum dot and polymer are some of these hybrid nanoparticle platforms. The quantum dot hybrid system possesses photonic and magnetic properties, allowing photothermal therapy and live multimodal imaging of cancer. These quantum dots were used to convey medicines to cancer cells. Hybrid polymer nanoparticles were utilized for the systemic delivery of small interfering RNA to malignant tumors and metastasis. They allowed non-invasive imaging to track in real-time the biodistribution of small interfering RNA in the whole body. They offer an opportunity to treat cancers by specifically silencing target genes. This review highlights the major nanotechnology approaches to effectively treat cancer and metastasis.

Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease

“…290 Additionally, polymer−lipid hybrid nanoparticles that combine the benefits of polymers and lipids have a high efficiency of drug delivery and low toxicity. 290 Hybrid biomaterials combining nanosized organic and inorganic or even bioactive ingredients into a single material, such as inorganic-graft-organic core corona shell nanostructures and hybrid nanoparticles based on mesoporous silica, have endowed a single material with many different properties for specific biomedical applications. 291,292 It is promising to note that hybrid nanocarriers, which are mainly used in the field of oncology, could also be applied to hepatology.…”

Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives

“…The Quantum Dots (QDs) are fluorescent semiconductor nanocrystals of about 10 nm, composed of a core coated with an envelope. QD-containing NPs have found applications in cancer medical imaging, cancer cell tracking, cancer photodynamic therapy, and cancer diagnosis [180].…”

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

“…As illustrated in Figure 1, these drugs have been rendered almost ineffective. Recent approaches in nanomedicine have prompted the development of effective theranostic platforms for a myriad of biological and biomedical applications [2]. Nanomaterials (i.e., niosomes [3], polymer-based nanocapsules [4], nanoparticles (NPs) [5][6][7][8], metal nanocages [9], nanocomposites [10], nanoliposomes [11], and engineered nanohydrogels [12]), with highly controlled geometry and physic-chemical properties, have been introduced as promising tools for recognizing cancer tissues and also serve as novel drug delivery systems (DDSs) to achieve active targeting [2,[13][14][15][16][17][18][19][20][21].…”

“…Recent approaches in nanomedicine have prompted the development of effective theranostic platforms for a myriad of biological and biomedical applications [2]. Nanomaterials (i.e., niosomes [3], polymer-based nanocapsules [4], nanoparticles (NPs) [5][6][7][8], metal nanocages [9], nanocomposites [10], nanoliposomes [11], and engineered nanohydrogels [12]), with highly controlled geometry and physic-chemical properties, have been introduced as promising tools for recognizing cancer tissues and also serve as novel drug delivery systems (DDSs) to achieve active targeting [2,[13][14][15][16][17][18][19][20][21]. It is now believed that nanotechnology can purposefully improve the clinical outcome of cancer therapies through improving the tolerability of the efficacy of novel drugs [22] or delivering proteins, DNA, RNA, and various types of jected synergistic tetravalent RNA-NPs into the tail-vein of mice.…”