Nanomedicine: an emerging era of theranostics and therapeutics for rheumatoid arthritis

Qamar, Naila; Arif, Ammara; Bhatti, Attya; John, Peter

doi:10.1093/rheumatology/kez286

Cited by 17 publications

(10 citation statements)

References 41 publications

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“…Adverse events from currently available non‐selective RA treatments can be minimized by encapsulating these medicines into nanocarriers for a more precise approach to administering the medications at the intended site of action, preventing repeated or heavy dosing, increasing drug solubility and pharmacokinetics, and achieving an optimal drug concentration locally. [ 10 ] Preclinical studies have utilized nanocarriers, including dendrimers, micelles, nanoemulsions, liposomes, and nanogels, for RA treatment. However, a recently published clinical trial suggested that curcumin nanomicelles have limited benefits in patients with RA.…”

Section: Advancement Of Nanomedicine In Ra Treatmentmentioning

confidence: 99%

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Han

Pang

2021

Adv Funct Materials

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Rheumatoid arthritis (RA) affects the joints and extra-articular organs and poses a significant health care problem in the modern era. Although current standard treatment modalities successfully control RA flares, no curative treatment modality for RA has been developed. Nanomedicines have addressed the drug side effects and limited efficacy of RA treatment. However, synthetic nanoparticles (NPs) can be toxic and induce immune responses in vivo, posing a risk of further RA progression. Biomimetic nanodrug delivery systems have the potential to improve the biocompatibility of synthetic NPs and the stability and targeting of pharmaceuticals in vivo. For many immune-related diseases with a complex pathogenesis and that involve a large number of different cell types, biomimetic nanodelivery systems can reduce the immunogenicity of NPs. Furthermore, some bioinspired strategies can mimic certain components of the pathological process, allowing for a more precise drug delivery and effective disease control via the carriers. This article highlights recent research on biomimetic nanodelivery systems for the treatment of RA and categorizes the design methodologies for various targets and carriers.

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Section: Advancement Of Nanomedicine In Ra Treatmentmentioning

confidence: 99%

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Han

Pang

2021

Adv Funct Materials

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“…Recent research has focused on the development of nanoparticle drug delivery systems that actively or passively target inflamed joints [7] while also improving the release of insoluble drugs, thereby maximizing bioavailability and therapeutic efficacy. Such drug delivery systems can significantly prolong drug half-life in the body and promote drug accumulation in the joints [8].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

Gou

Liao

et al. 2023

Acta Materia Medica

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Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of their systemic mechanisms, short half-lives and low bioavailability. Consequently, these agents must be used at high doses and delivered frequently, thereby increasing costs and the risk of adverse effects. Drug delivery systems, such as nanoparticles, liposomes and micelles, can significantly prolong drug half-life in the body and enable targeted delivery into the joints. In this review, we comprehensively describe the pathogenesis and clinical diagnosis of rheumatoid arthritis, and summarize recent advances in targeted therapeutic strategies, particularly nano-targeting systems for rheumatoid arthritis.

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“…The highly innovative field of nanotheranostics has been expanding now for more than two decades, with easy-to-scale nanomaterials emerging as potential candidates to treat a variety of pathologies, such as cancer (1)(2)(3)(4), autoimmune diseases (5,6) or neurodegenerative disorders (7,8). The therapeutic interest in nanomaterials, and particularly in nanoparticles, is in part kindled by the chemical and physical versatility of these materials.…”

Section: Introductionmentioning

confidence: 99%

The Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment

2021

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The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which has enhanced the interest in studying them as theranostic agents over recent years. As IONPs begin to be used for different biomedical applications, it is important to know how they affect the immune system and its different cell types, especially their interaction with the macrophages that are involved in their clearance. How immune cells respond to therapeutic interventions can condition the systemic and local tissue response, and hence, the final therapeutic outcome. Thus, it is fundamental to understand the effects that IONPs have on the immune response, especially in cancer immunotherapy. The biological effects of IONPs may be the result of intrinsic features of their iron oxide core, inducing reactive oxygen species (ROS) and modulating intracellular redox and iron metabolism. Alternatively, their effects are driven by the nanoparticle coating, for example, through cell membrane receptor engagement. Indeed, exploiting these properties of IONPs could lead to the development of innovative therapies. In this review, after a presentation of the elements that make up the tumor immunological microenvironment, we will review and discuss what is currently known about the immunomodulatory mechanisms triggered by IONPs, mainly focusing on macrophage polarization and reprogramming. Consequently, we will discuss the implications of these findings in the context of plausible therapeutic scenarios for cancer immunotherapy.

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Nanomedicine: an emerging era of theranostics and therapeutics for rheumatoid arthritis

Cited by 17 publications

References 41 publications

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

The Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment

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