Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair

Santos, Tiago; Boto, Carlos; Saraiva, Cláudia; Bernardino, Liliana; Ferreira, Lino

doi:10.1016/j.tibtech.2016.02.003

Cited by 26 publications

(16 citation statements)

References 14 publications

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“…In these cases, stem cell transplantation offers some hope. 12,20 Currently common methods for stem cell transplantation are lateral ventricle puncture and LP. Stem cells can be successfully administered via LP, and this method results in larger numbers of migrated cells than intravenous administration.…”

Section: Discussionmentioning

confidence: 99%

A new method of subarachnoid puncture for clinical diagnosis and treatment: lateral atlanto-occipital space puncture

Gong¹,

Hai-yan²,

Yuan³

2018

Journal of Neurosurgery

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OBJECTIVE Lumbar puncture may not be suitable for some patients needing subarachnoid puncture, while lateral C1-2 puncture and cisterna magna puncture have safety concerns. This study investigated lateral atlanto-occipital space puncture (also called lateral cisterna magna puncture) in patients who needed subarachnoid puncture for clinical diagnosis or treatment. The purpose of the study was to provide information on the complications and feasibility of this technique and its potential advantages over traditional subarachnoid puncture techniques. METHODS In total, 1008 lateral atlanto-occipital space puncture procedures performed in 667 patients were retrospectively analyzed. The success rate and complications were also analyzed. All patients were followed up for 1 week after puncture. RESULTS Of 1008 lateral atlanto-occipital space punctures, 991 succeeded and 17 failed (1.7%). Fifteen patients (2.25%) reported pain in the ipsilateral external auditory canal or deep soft tissue, 32 patients (4.80%) had a transient increase in blood pressure, and 1 patient (0.15%) had intracranial hypotension after the puncture. These complications resolved fully in all cases. There were no serious complications. CONCLUSIONS Lateral atlanto-occipital space puncture is a feasible technique of subarachnoid puncture for clinical diagnosis and treatment. It is associated with a lower rate of complications than lateral C1-2 puncture or traditional (suboccipital) cisterna magna puncture. It may have potential in the neurological diagnostic and treatment fields.

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Section: Discussionmentioning

confidence: 99%

A new method of subarachnoid puncture for clinical diagnosis and treatment: lateral atlanto-occipital space puncture

Gong¹,

Hai-yan²,

Yuan³

2018

Journal of Neurosurgery

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“…This, when coupled with neuro‐regenerative molecules on gelatin or PLGA support systems, may provide perfect tools for neuroregenerative medicine in the future. [ 153 ] Yet another different approach has been demonstrated by Yuan et al where the authors have prepared superparamagnetic iron oxide‐AuNPs functionalized with Nerve Growth Factor. These NPs were shown to be controlled by the application of the magnetic field and were highly potent in inducing neuronal growth.…”

Section: Bbb Modifications and Noninvasive Delivery Of Nanomedicine Imentioning

confidence: 99%

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee

Madamsetty

Bhattacharya

et al. 2020

Adv Funct Materials

107

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Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and amyotrophic lateral sclerosis. The treatment of the same remains a daunting challenge due to the limited access of therapeutic moieties across the blood–brain barrier. Engineered nanoparticles with a size less than 100 nm provide multifunctional abilities for solving these biomedical and pharmacological issues due to their unique physico‐chemical properties along with capability to cross the blood–brain barrier. Needless to mention, there is a scarcity of review articles summarizing recent developments of various nanomaterials including liposomes, polymeric nanoparticles, metal nanoparticles, and bio‐nanoparticles toward the therapeutic and theranostics applications for various neurodegenerative disorders. Here, a broad spectrum of nanomedicinal approaches to eradicate neurodegenerative disorders is provided, along with a brief account of neuroprotection and neuronal tissue regeneration, current clinical status, issues related to safety, toxicity, challenges, and future outlook.

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“…La nanomedicina es la aplicación de la nanotecnología para el diagnóstico y tratamiento de enfermedades, y para el monitoreo y control de sistemas biológicos, un área interdisciplinaria de la investigación en ciencias básicas, ingeniería y medicina (2,4,6,7).…”

Section: Introductionunclassified

“…Entre los desarrollos más importantes de la nanomedicina se encuentran sistemas de diagnóstico para la detección temprana de enfermedades (8-10), recubrimientos para mejorar la biocompatibilidad de implantes o prótesis, aditivos para mejorar la solubilidad y biodisponibilidad de fármacos (11,12), materiales para ingeniería tisular, medicina regenerativa y biomiméticos (13)(14)(15), sistemas de encapsulación, transporte y administración dirigida y controlada de fármacos y genes a tejidos o células específicas (6,9,(11)(12)(13)15,16), adyuvantes para vacunas (11) y terapias antitumorales (7,17), entre otras.…”

Section: Introductionunclassified

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Gómez-Gallego

Urcuqui-Inchima

Hernández

2016

iatreia

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RESUMENLas nanopartículas (NP) son estructuras con tamaño en la escala nanométrica (1 x 10 -9 m). Por sus características, en los últimos años ha crecido su potencial para usarlas en los campos biotecnológico y biomédico en una amplia gama de aplicaciones, tales como el diagnóstico, la terapia y la medicina regenerativa.El sistema inmunológico es el responsable de la defensa del cuerpo ante organismos patógenos y otros agentes extraños, como las NP, que pueden ser reconocidas por dicho sistema, interactuar con él y modular su función induciendo efectos inmunosupresores o inmunoestimuladores. Las primeras se podrían utilizar como agentes terapéuticos antinflamatorios o para tratar las enfermedades autoinmunes, y las que activan el sistema inmune, como adyuvantes en vacunación o potenciadores de la respuesta inmune en cáncer y otras enfermedades humanas. Sin embargo, su uso en nanomedicina debe estar sujeto a ensayos previos que determinen su efecto en la respuesta inmune antes de aplicarlas a los sistemas biológicos. Por esta razón es importante conocer su composición, tamaño y características superficiales, entre otras propiedades fisicoquímicas, directamente implicadas en los efectos sobre el sistema inmune. Se presenta una visión general de la relación entre las propiedades fisicoquímicas de las NP candidatas para ser usadas en los campos biomédico y biotecnológico y su actividad inmunomoduladora. PALABRAS CLAVEInmunomodulación; Nanomedicina; Nanopartículas SUMMARYImmunomodulating effect of nanoparticles used in nanomedicine Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10 -9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in

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Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair

Cited by 26 publications

References 14 publications

A new method of subarachnoid puncture for clinical diagnosis and treatment: lateral atlanto-occipital space puncture

A new method of subarachnoid puncture for clinical diagnosis and treatment: lateral atlanto-occipital space puncture

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

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