Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

Hafez, Dina A.; Elkhodairy, Kadria A.; Teleb, Mohamed; Elzoghby, Ahmed O.

doi:10.1080/17425247.2020.1723542

Cited by 27 publications

(11 citation statements)

References 36 publications

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“…The pharmacokinetic results of the verapamil treated group and the PPR treated group are in close agreement, suggesting the effectiveness of PPR as Pgp inhibitor. DPD phytosomes have offered improved pharmacokinetics, augmented metabolic stability, amplified membrane permeability, and boosted bioavailability(Hafez et al, 2020).…”

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confidence: 99%

Piperine phytosomes for bioavailability enhancement of domperidone

Islam

Irfan

Hussain

et al. 2021

Journal of Liposome Research

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The markedly low oral bioavailability of domperidone (anti-emetic drug) is associated with rapid first-pass metabolism in the intestine and liver. To counteract such affects, there is a need to devise a strategy to enhance absorption and subsequently bioavailability. Thus, the current study was aimed at synthesizing phytosomes consisting of phosphatidylcholine and piperine (a Pglycoprotein inhibitor). Phytosomes were prepared by salting-out method. The developed phytosomes were extensively characterized for size, zeta potential, polydispersity index, entrapment efficiency (EE %), infrared spectroscopy, X-ray diffraction, in-vitro drug release, exvivo permeation, in-vivo pharmacokinetic and toxicity. The engineered formulations of phytosomes with piperine exhibited a significant improvement in oral bioavailability of domperidone (79.5%) in comparison with the pure drug suspension under the same conditions. Pharmacokinetic parameters such as maximal plasma concentration (Cmax) and the plasma concentration (estimated from area under the curve; AUC) of domperidone have been greatly increased relative to drug alone. The improved drug absorption was attributed to inhibition of Pglycoprotein transporter. The findings of current research work suggest that the optimized phytosomes based drug delivery containing phytochemicals as bioenhancers have the potential to improve bioavailability of poorly bioavailable drugs that are substrate to P-glycoprotein.

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confidence: 99%

Piperine phytosomes for bioavailability enhancement of domperidone

Islam

Irfan

Hussain

et al. 2021

Journal of Liposome Research

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“…Dina A. Hafez et al reported that in another controlled study, lecithin curcumin phytosomal complex (Meriva®) was administered to 160 patients. Lecithinized curcumin minimise the negative effects of chemotherapy and radiotherapy, demonstrating the usefulness of curcumin phytosomes as a supporter of cancer treatment [ 59 ]. Reyhaneh Moradi Marjaneh et al evaluated the anticancer potential of phytosomal curcumin, CT26 cells were subjected to enhancing the concentrations of curcumin (0–1000 M) and 5-FU (1–50 mg/ml) for 24, 48, and 72 h, both separately and in combination.…”

Section: Advancement and Application Of Phytosomes In Cancermentioning

confidence: 99%

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

Gaikwad

Morade

Kothule

et al. 2023

Heliyon

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“…The performance of these nanoformulations can be improved by modifying their composition, particle size and surface characteristics to increase their efficacy, reduce side effects and overcome drug resistance. It is expected that these phytochemicals incorporated into nanoformulations will have altered bioavailability, permeability and toxicity profiles and will have more efficacy in cancer therapy ( 28 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

A spotlight on alkaloid nanoformulations for the treatment of lung cancer

Sindhoor¹,

Naveen²,

Rao

et al. 2022

Front. Oncol.

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Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility, low bioavailability, and inadequacies such as lack of specificity to cancer cells and indiscriminate distribution in the tissues. Incorporating the alkaloids into nanoformulations can overcome the said limitations paving the way for effective delivery of the alkaloids to the site of action in sufficient concentrations, which is crucial in tumor targeting. Our review attempts to assess whether alkaloid nanoformulation can be an effective tool in lung cancer therapy. The mechanism of action of each alkaloid having potential is explored in great detail in the review. In general, Alkaloids suppress oncogenesis by modulating several signaling pathways involved in multiplication, cell cycle, and metastasis, making them significant component of many clinical anti-cancerous agents. The review also explores the future prospects of alkaloid nanoformulation in lung cancer. So, in conclusion, alkaloid based nanoformulation will emerge as a potential gamechanger in treating lung cancer in the near future.

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Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

Cited by 27 publications

References 36 publications

Piperine phytosomes for bioavailability enhancement of domperidone

Piperine phytosomes for bioavailability enhancement of domperidone

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

A spotlight on alkaloid nanoformulations for the treatment of lung cancer

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