Nanomedicine for implants: A review of studies and necessary experimental tools

Liu, Huinan; Webster, Thomas J.

doi:10.1016/j.biomaterials.2006.08.049

Cited by 532 publications

(374 citation statements)

References 51 publications

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“…materials with nanometrescaled grains) can be used to produce nanometre features on biomaterial surfaces to guide cell behaviour along a desired biological response [9,10]. In bone-regeneration applications, promising results have been obtained with the nanophase materials ceramics and metals, with which increased osteoblast adhesion, proliferation and calcium deposition have been observed compared with conventional materials (i.e.…”

Section: Nanocoatings and Nanophase Materialsmentioning

confidence: 99%

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Nanotechnology in regenerative medicine: the materials side

Engel

Michiardi

Navarro

et al. 2008

Trends in Biotechnology

299

205

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Section: Nanocoatings and Nanophase Materialsmentioning

confidence: 99%

“…Although polymers are the most used nanoparticles in the delivery area, the use of ceramics has also been investigated. Hydroxyapatite nanoparticles functionalised with biomolecules could enhance osteoblast adhesion and bone regeneration [9].…”

Section: Dip-pen Lithographymentioning

confidence: 99%

Nanotechnology in regenerative medicine: the materials side

Engel

Michiardi

Navarro

et al. 2008

Trends in Biotechnology

299

205

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“…We performed mineralization tests of the composite with HA (which is a naturally occurring form of calcium apatite and present as HA crystals in bone tissue) under physiological concentrations of Ca 2+ and PO 4 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the ability of nanotubes to act as an osteoinductor has been recently demonstrated [37 39]. In these studies, functionalized CNTs were able to induce the nucleation and growth of HA crystals in vitro under physiological concentrations of Ca 2+ and PO 4 3 . Additionally, the interaction of CNTs with osteoblasts (bone-forming cells) has also been described and good biocompatibility and bone Nano Res (2009) 2: 462 473…”

Section: Introductionmentioning

confidence: 99%

Nanostructured 3-D collagen/nanotube biocomposites for future bone regeneration scaffolds

et al. 2009

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The fi eld of bionanotechnology has been rapidly growing during the last few years and we can now envision a controllable integration between biological and artificial matter, where new biomimetic structures with a wide range of chemical and physical properties will promote the development of a novel generation of medical devices. In this work we describe a collagen/carbon nanotube composite which has the potential to be used as a scaffold for tissue regeneration. Because this biocomposite incorporates the advantageous properties of both collagen and carbon nanotubes, it has most of the characteristics that an ideal biomaterial requires in order to be used as an osteoinductive agent. This biocomposite is bioresorbable and biodegradable and has the desired mechanical rigidity while maintaining a three-dimensional(3-D) nanostructured surface. Tuned stability and swelling were achieved under fluid environments by varying the amount of carbon nanotubes (CNTs) incorporated into the composite. These variations can dictate the degree of interaction between fibroblastic cells and the biomaterials. Proof-of-concept was shown by performing an in vitro induced mineralization of hydroxylapatite crystals under physiological conditions. Furthermore, the ability to attach biofunctional groups to the CNT walls can open a new road for tissue regeneration since the combination of CNTs with specific growth factors or cellular ligands can create an environment capable of signaling and infl uencing specifi c cell functions. Our observations suggest that collagen/carbon nanotube biocomposites will have important uses in a wide range of biotechnological areas.

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“…TiNTs have shown great potential in optics, energy storage, bioelectronics as well as for medical devices. [14] Biocompatible scaffolds for hosting functional guest molecules can be fabricated, taking advantage of the large number of hydroxyl groups present on the tube walls. These provide the possibility of incorporating desired functional groups, to load drugs or graft capping molecules and thus establish advanced storage and release mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Visible‐Light‐Triggered Drug Release from TiO₂ Nanotube Arrays: A Controllable Antibacterial Platform

et al. 2015

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Abstract:In this work, we use a double-layered stack of TiO 2 nanotubes (TiNTs) to construct a visible-light triggered drug delivery system. Key for visible-light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate the principle, we loaded antibiotic (ampicillin sodium (AMP)) in the lower part of the TiO 2 nanotube stack, triggered visible light induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane-grafted in hydrophilic bottom layer for drug storage. Thus visible-light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.2 Controllable drug delivery has attracted wide interest in biomedicine and other fields of science in order to achieve a targeted use of an active substance at the right time and the right place.Particularly drug release mechanisms with triggers that respond to surrounding factors, such as pH, [1] temperature, [2] illumination and ionic strength [3] are of a high practical significance. Many nanomaterials are, or can be designed to be particularly sensitive to environmental factors and therefore a steeply increasing number of studies is being carried out on the development of "smart" nanomaterial-based drug carriers. Systems have been developed with great biocompatibility and the feasibility of targeted drug delivery with a much higher control over the pharmacokinetics (which can decrease systemic toxicity). [4,5] For example, Dai and his coworkers prepared pH-sensitive polyethylene glycol functionalized graphene oxide for the delivery of aromatic drugs, [6a, 6b] or hierarchical hollow CaCO 3 nanoparticles have been reported for a localizing drug release reacting on a pH change. [6c] Another example is the work of Zhang et al. that reported a free-radical precipitation polymerization method to synthesize a temperature responding drug carrier. [7] As drug carrier a wide range of nanoparticles, [8] microgel, [9] nanotubes [10,11] and polymeric micelles [12, 2b] have been explored. Especially, drug carriers based on nanotubes have various beneficial features due to their intrinsic high surface-to-volume ratio, well defined geometry and stable structure. [13] In the past decade TiO 2 nanotube arrays (TiNTs) grown by a self-organizing electrochemical anodization process have attracted tremendous scientific interest due to the combination of geometric features with an inherent photocatalytic activity. TiNTs have shown great potential in optics, energy storage, bioelectronics as well as for medical devices. [14] Biocompatible scaffolds for hosting functional guest molecules can be fabricated, taking advantage of the large number of hydroxyl groups present on the tube walls. These provide the possibility of incorporating desired functional groups, to load drugs or graft capping molecules and thus establish advanced storage and relea...

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Nanomedicine for implants: A review of studies and necessary experimental tools

Cited by 532 publications

References 51 publications

Nanotechnology in regenerative medicine: the materials side

Nanotechnology in regenerative medicine: the materials side

Nanostructured 3-D collagen/nanotube biocomposites for future bone regeneration scaffolds

Visible‐Light‐Triggered Drug Release from TiO₂ Nanotube Arrays: A Controllable Antibacterial Platform

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Nanomedicine for implants: A review of studies and necessary experimental tools

Cited by 532 publications

References 51 publications

Nanotechnology in regenerative medicine: the materials side

Nanotechnology in regenerative medicine: the materials side

Nanostructured 3-D collagen/nanotube biocomposites for future bone regeneration scaffolds

Visible‐Light‐Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform

Contact Info

Product

Resources

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Visible‐Light‐Triggered Drug Release from TiO₂ Nanotube Arrays: A Controllable Antibacterial Platform