Nanomedicine in coronary artery disease

Ambesh, Paurush; Campia, Umberto; Obiagwu, Chukwudi; Bansal, Rashika; Shetty, Vijay; Hollander, Gerald; Shani, Jacob

doi:10.1016/j.ihj.2017.02.007

Cited by 37 publications

(17 citation statements)

References 84 publications

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“…Most of the research is intended for treatment against the cancer disease, since it is the foremost reason of death worldwide nowadays [ 197 , 198 ]. In case of the cancer disease, different organs of the body are affected, and therefore the need for the development of an alternative medicine to target the cancerous cells is the utmost priority among the modern researchers, however, a number of applications of nanomedicine to other ailments is also being worked on [ 199 , 200 ]. These delivery systems are categorized in terms of their surface charge, particle size, size dispersion, shape, stability, encapsulation potential and biological action which are further utilized as per their requirements [ 33 ].…”

Section: Natural Product-based Nanotechnology and Drug Deliverymentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Section: Natural Product-based Nanotechnology and Drug Deliverymentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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“…The treatment of CAD using nanotechnology may involve non-invasive techniques aimed to reduce lipid levels, targeting angiogenesis, inflammation, intra-arterial thrombus, and invasive techniques such as anti-restenosis treatment after the percutaneous coronary intervention (PCI), prevention of in-stent restenosis, enhancement of healing after PCI, and using biosynthetic CABG grafts [22]. Targeting mediators of inflammation and inflammatory pathways to attenuate inflammation have been described as a therapeutic strategy to attenuate the progression of atherosclerosis and prevent rupture of unstable plaque.…”

Section: Therapeutic Role In Vascular Diseasesmentioning

confidence: 99%

Nanomaterial-Mediated Theranostics for Vascular Diseases

Agrawal

Nooti

Singh

et al. 2020

JNT

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Nanotechnology could offer a new complementary strategy for the treatment of vascular diseases including coronary, carotid, or peripheral arterial disease due to narrowing or blockage of the artery caused by atherosclerosis. These arterial diseases manifest correspondingly as angina and myocardial infarction, stroke, and intermittent claudication of leg muscles during exercise. The pathogenesis of atherosclerosis involves biological events at the cellular and molecular level, thus targeting these using nanomaterials precisely and effectively could result in a better outcome. Nanotechnology can mitigate the pathological events by enhancing the therapeutic efficacy of the therapeutic agent by delivering it at the point of a lesion in a controlled and efficacious manner. Further, combining therapeutics with imaging will enhance the theranostic ability in atherosclerosis. Additionally, nanoparticles can provide a range of delivery systems for genes, proteins, cells, and drugs, which individually or in combination can address various problems within the arteries. Imaging studies combined with nanoparticles helps in evaluating the disease progression as well as the response to the treatment because imaging and diagnostic agents can be delivered precisely to the targeted destinations via nanocarriers. This review focuses on the use of nanotechnology in theranostics of coronary artery and peripheral arterial disease.

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“…For this purpose, drug-eluting stents (DES) are performed. Therefore, anti-proliferative drugs can be delivered using nanoparticles which help in drug delivery [29].…”

Section: Role Of Nanoparticles In Disease Diagnosis and Treatmentmentioning

confidence: 99%

The Role of Nanoparticles in the Diagnosis and Treatment of Diseases

et al. 2020

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Nanotechnology is involved in the diagnosis and treatment of infectious and inflammatory diseases. It has shown a good role in regenerating, restoring and repairing damaged body parts, such as the heart, lungs and blood vessels. Nanoparticles (NPs) are helpful in osteoblasts formation and also used in the treatment of bone inflammation, skin infections, tuberculosis (TB), human immunodeficiency virus (HIV), Parkinson’s disease, atherosclerosis, cardiovascular and pulmonary diseases. They also assist the anti-inflammatory drugs in penetrating the skin. Platinum nanoparticles (NP) are used in bone allograft and dentistry while silver NPs possess an excellent potential against viruses, fungi and bacteria. For diagnostic purposes, nanoparticles are mostly used in the form of nanorobots, microchips and biosensors. Quantum dots give information about the tumor; the gold nano-particles are ideal to detect the antibodies of hepatitis and also for RNA and DNA delivery. Nanomaterials play an important role in the management of plant diseases and the activation of their defense mechanisms. The NPs of copper and silver are directly toxic to microorganisms while those of zinc, silicon, manganese, copper and boron have a function in host defense as a fertilizer and alter the nutritional status of the crop. Enzyme-based biosensors coated with Ti, Cu, Ag or Au-NPs greatly enhance the sensitivity of diagnostic probes for the detection of plant infections. The nano-Zn products have been effectively used to control viral, fungal, phytoplasma or bacterial diseases in crop plants. Nanoparticles are also used in packing edible food films.

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Nanomedicine in coronary artery disease

Cited by 37 publications

References 84 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

Nanomaterial-Mediated Theranostics for Vascular Diseases

The Role of Nanoparticles in the Diagnosis and Treatment of Diseases

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