2024
DOI: 10.2174/0109298673258987231004092334
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Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy

Rupesh K. Gautam,
Pooja Mittal,
Rajat Goyal
et al.

Abstract: Nanomedicine's application of nanotechnology in medicine holds tremendous potential for diagnosing and treating life-threatening diseases such as cancer. Unlike conventional therapies, nanomedicine offers a promising strategy to enhance clinical outcomes while minimizing severe side effects. The principle of drug targeting enables specific delivery of therapeutic agents to their intended sites, making it a more precise and effective therapy. Combination strategies, such as the co-delivery of chemotherapeutic d… Show more

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Cited by 1 publication
(3 citation statements)
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“…The possibility of enhancing the solubility and stability of MDM2 inhibitors in nanoparticulate forms may improve their bioavailability, a critical factor in clinical efficacy. A key advantage of these nano-formulations is their capability for controlled drug release, ensuring a sustained therapeutic level and potentially allowing for a reduced dosing frequency ( Gautam et al, 2023 ). Moreover, the potential of nano-formulations to codeliver MDM2 inhibitors alongside other therapeutic compounds or genetic materials represents a strategic approach to counteract drug resistance in cancer cells.…”
Section: Challenges and Future Directionsmentioning
confidence: 99%
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“…The possibility of enhancing the solubility and stability of MDM2 inhibitors in nanoparticulate forms may improve their bioavailability, a critical factor in clinical efficacy. A key advantage of these nano-formulations is their capability for controlled drug release, ensuring a sustained therapeutic level and potentially allowing for a reduced dosing frequency ( Gautam et al, 2023 ). Moreover, the potential of nano-formulations to codeliver MDM2 inhibitors alongside other therapeutic compounds or genetic materials represents a strategic approach to counteract drug resistance in cancer cells.…”
Section: Challenges and Future Directionsmentioning
confidence: 99%
“…Moreover, the potential of nano-formulations to codeliver MDM2 inhibitors alongside other therapeutic compounds or genetic materials represents a strategic approach to counteract drug resistance in cancer cells. Additionally, the ability to leverage the enhanced permeability and retention of compounds by nanoparticles can facilitate drug penetration and retention within tumor tissues ( Gautam et al, 2023 ). This innovation in drug delivery aligns with the principles of personalized medicine, offering the prospect of tailoring cancer treatments to the unique molecular profiles of individual patients, thereby optimizing therapeutic outcomes.…”
Section: Challenges and Future Directionsmentioning
confidence: 99%
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