2017
DOI: 10.2174/1874844901704010001
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Nanomedicine-Mediated Combination Drug Therapy in Tumor

Abstract: Background:Combined chemotherapy has gradually become one of the conventional methods of cancer treatment due to the limitation of monotherapy. However, combined chemotherapy has several drawbacks that may lead to treatment failure because drug synergy cannot be guaranteed, achievement of the optimal synergistic drug ratio is difficult, and drug uptake into the tumor is inconsistent. Nanomedicine can be a safe and effective form of drug delivery, which may address the problems associated with combination chemo… Show more

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Cited by 6 publications
(8 citation statements)
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References 69 publications
(76 reference statements)
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“…A detailed summary of the application of nanotechnology for delivery of combination chemotherapy with many advantages over conventional combination therapy is presented and they have described many phytodrug combinations with synthetic and nature derived anticancer drugs (PCT and ETP; TPT and VCR; VCR and QUR; PCT and DOX; CUR and DOX; PCT and CUR to mention some) that have been developed as NPs, liposomes, lipid-polymer hybrid NPs and micelles delivering enhanced therapeutic efficacy for the combination drugs (Chen et al, 2017). Table 1 gives the comparative summary of the various nanotech delivery systems.…”
Section: Micellesmentioning
confidence: 99%
“…A detailed summary of the application of nanotechnology for delivery of combination chemotherapy with many advantages over conventional combination therapy is presented and they have described many phytodrug combinations with synthetic and nature derived anticancer drugs (PCT and ETP; TPT and VCR; VCR and QUR; PCT and DOX; CUR and DOX; PCT and CUR to mention some) that have been developed as NPs, liposomes, lipid-polymer hybrid NPs and micelles delivering enhanced therapeutic efficacy for the combination drugs (Chen et al, 2017). Table 1 gives the comparative summary of the various nanotech delivery systems.…”
Section: Micellesmentioning
confidence: 99%
“…Currently, combination strategies are widely applied in cancer therapy and are a standard method for cancer treatment. 34,35 Notably, combinations of anticancer drugs can interact synergistically, additively, or antagonistically. 34 Thus, the optimized ratio of ELC and chemotherapeutic drugs should be screened to achieve the optimal therapeutic effect of the combined therapy.…”
Section: Introductionmentioning
confidence: 99%
“…34,35 Notably, combinations of anticancer drugs can interact synergistically, additively, or antagonistically. 34 Thus, the optimized ratio of ELC and chemotherapeutic drugs should be screened to achieve the optimal therapeutic effect of the combined therapy. However, optimized ratios of drug combinations may not be realized in vivo due to differences in the pharmacokinetics, tissue distributions, and cell membrane penetration abilities of drugs.…”
Section: Introductionmentioning
confidence: 99%
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