Nanomedicine Strategies for Targeting Skin Inflammation

Abstract

Topical treatment of skin diseases is an attractive strategy as it receives high acceptance from patients, resulting in higher compliance and therapeutic outcomes. Recently, the use of variable nanocarriers for dermal application has been widely explored, as they offer several advantages compared with conventional topical preparations, including higher skin penetration, controlled and targeted drug delivery and the achievement of higher therapeutic effects. This article will focus on skin inflammation or dermatitis as it is one of the most common skin problems, describing the different types and causes of dermatitis, as well as the typical treatment regimens. The potential use of nanocarriers for targeting skin inflammation and the achievement of higher therapeutic effects using nanotechnology will be explored.

Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels

“…Though nanoparticle induced immunogenicity is desirable in certain instances -vaccine formulations for example 65 , 66 - further immune cell activation in inflammatory skin diseases is not. 67 Indeed, the bio- and immune- compatibility of the tNGs towards skin LCs is essential to their use in the topical treatment of a wide range of skin diseases.…”

Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing

“…Whilst it is probable that penetrance of nanoparticles into the viable epidermis changes considerably when applied to inflamed or lesional skin, surprisingly few studies have investigated the use of drug loaded nanoparticles in the skin diseases for which they are intended. Reasons for this apparent lack include the limited availability of diseased human skin for experimental purposes and the popularity of animal models in the assessment of nanoparticle mediated anti-inflammatory effects [18]. Rodent skin however demonstrates major anatomical and physiological differences relative to human skin, something that skin models aim to overcome [19][20][21].…”

Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

“…Liposomes are phospholipid bilayer systems with an aqueous core, which may be loaded with hydrophilic drugs in the core or lipophilic drugs trapped within the phospholipid bilayers [17,57]. Concerning their phospholipid constitution, liposomes are able to interact with the stratum corneum's lipids, allowing MXD skin permeation, or through the hair follicles, creating MXD's depots [58].…”

“…Liposomes are highly biocompatible and biodegradable, remaining in blood circulation for extended periods of time. Nonetheless, their applicability is restricted due to stability issues, namely aggregation, drug leakage, hydrolysis and particle size alterations [57,59]. MXD-loaded liposomes reportedly enhanced skin permeation through the stratum corneum pathway and depot formation with significant improvements, namely MXD sustained release and targeting features (Table 2).…”