Nanomedicines and cell-based therapies for embryonal tumors of the nervous system

Moukhtari, Souhaila H. El; Garbayo, Elisa; Fernández‐Teijeiro, Ana; Rodríguez-Nogales, Carlos; Couvreur, Patrick; Blanco-Prieto, María J.

doi:10.1016/j.jconrel.2022.06.010

Cited by 9 publications

(8 citation statements)

References 166 publications

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“…Liposome delivery systems are currently accepted as the most suitable delivery system for encapsulated anticancer drugs with respect to pharmacological stability and pharmacokinetics, and liposomes are biodegradable and have the potential to be loaded with high concentrations of anticancer drugs 103,104 . There are also R8 peptide‐PEGylated targeted liposomes for the treatment of gliomas, and data suggest good sustained release properties, improved stability, and increased liposomal ability to cross the blood–BBB 105,106 . Liposomes as a type of drug delivery system have significant advantages in antitumor drug delivery and are used in clinical practice to improve the efficacy of antitumor drugs and drug resistance.…”

Section: Overview Of Npsmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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Section: Overview Of Npsmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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“…For anaplastic large cell lymphoma (ALCL), protamine nanomedicine with aptamers, dsDNA/drug payload, and siRNA has the potential to offer cell-selective chemotherapy and oncogene-specific gene therapy by targeting diagnostic biomarkers and therapeutic targets [ 146 ]. Additionally, nanomedicines and cell-based therapies are currently being investigated in phase I/II clinical trials for neuroblastoma and medulloblastoma, with the aim of reducing drug toxicity and improving efficacy [ 147 ]. Nanomedicine has demonstrated promise in overcoming the limitations of conventional chemotherapy for pediatric neuroblastoma [ 148 ].…”

Section: Pediatric Cancer Treatment and Researchmentioning

confidence: 99%

Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions

Omidian

Mfoafo

2023

Pharmaceutics

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The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood–brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there are inherent risks and limitations associated with the use of nanoparticles. This review provides a comprehensive summary of the existing literature on nanotechnology in pediatric medicine, highlighting its potential to revolutionize pediatric healthcare while also recognizing the challenges and limitations that need to be addressed.

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“…As a result, dosage limitations are imposed, causing harm to organs like the heart, lungs, and liver, thereby diminishing overall quality of life. 4…”

Section: Introductionmentioning

confidence: 99%

“…As a result, dosage limitations are imposed, causing harm to organs like the heart, lungs, and liver, thereby diminishing overall quality of life. 4 Nanomedicine faces certain challenges in treating glioblastoma. Tumor heterogeneity makes efficient targeting more difficult, and the blood-brain barrier restricts the entry of nanoparticles into the brain.…”

Section: Introductionmentioning

confidence: 99%

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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Nanomedicines and cell-based therapies for embryonal tumors of the nervous system

Cited by 9 publications

References 166 publications

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

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