Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing

Desmet, Céline; Préat, Véronique; Gallez, Bernard

doi:10.1016/j.addr.2018.02.001

Cited by 82 publications

(65 citation statements)

References 222 publications

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“…[85] During inflammation, phagocytes, mainly neutrophils, consume most of the oxygen [86] and produce bactericidal ROS. [87] However, Adv. Healthcare Mater.…”

Section: Redoxmentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

105

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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“…[85] During inflammation, phagocytes, mainly neutrophils, consume most of the oxygen [86] and produce bactericidal ROS. [87] However, Adv. Healthcare Mater.…”

Section: Redoxmentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

105

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“…In addition to being one step closer to clinical applicability, this study opens the door for EPR oximetry use in studying flap viability and interventions moving forward. EPR has already been shown to be effective in measuring wound response to treatments aimed at improving oxygenation . In addition, this technology could elucidate exactly how much ischemic insult various types of tissue may tolerate, as well as lay groundwork for studies to establish guidelines concerning when flap salvage is indicated.…”

Section: Discussionmentioning

confidence: 99%

“…EPR has already been shown to be effective in measuring wound response to treatments aimed at improving oxygenation. 33,34 In addition, this technology could elucidate exactly how much ischemic insult various types of tissue may tolerate, as well as lay groundwork for studies to establish guidelines concerning when flap salvage is indicated. These advances may translate into flap-survival improvement and a reduction in patient morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry

et al. 2019

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Objectives/Hypothesis To determine if electron paramagnetic resonance (EPR) oximetry is a viable technology to aid in flap monitoring. Study Design Prospective cohort. Methods This was a cohort study assessing accuracy and speed of EPR oximetry in detecting ischemia of a saphenous artery–based flap in a rat model, using transcutaneous oximetry as a control. Measurements were obtained under both resting and ischemic conditions for nine Sprague Dawley rats (18 flaps), for 3 postoperative days following flap elevation. Results The mean partial pressure of oxygen prior to tourniquet application was 66.9 ± 8.9 mm Hg with EPR oximetry and 64.7 ± 5.2 mm Hg with transcutaneous oximetry (P = .45). Mean partial pressures of oxygen during tourniquet application were 8.9 ± 3.2 mm Hg and 8.5 ± 2.9 mm Hg for EPR oximetry and transcutaneous oximetry, respectively (P = .48), and 67.2 ± 6.9 mm Hg and 65.3 ± 6.1 mm Hg after tourniquet release for EPR oximetry and transcutaneous oximetry, respectively (P = .44). The mean ischemia detection time of EPR oximetry was 49 ± 21 seconds. Conclusions Offering timely, accurate, and noninvasive tissue oxygen measurements, EPR oximetry is a promising adjunct in flap monitoring. Level of Evidence NA Laryngoscope, 129:E415–E419, 2019

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“…Specifically, oxygen is necessary in the hydroxylation reaction of proline and lysine from pro-collagen chains in order to stabilize the triple helices of collagen. Last but not least, another process that is oxygen dependent is represented by the wound contraction attributed to the differentiation of fibroblasts into contractile myofibroblasts, activated by TGF-β1, TGF-β2, and PDGF [ 38 ].…”

Section: Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing

Cited by 82 publications

References 222 publications

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

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