Nanomedicines for Overcoming Cancer Drug Resistance

Hu, Tingting; Gong, Hanlin; Xu, Jing; Huang, Yuan; Wu, Fengbo; He, Zhiyao

doi:10.3390/pharmaceutics14081606

Cited by 21 publications

(16 citation statements)

References 299 publications

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“…One distinguishing characteristic of photothermal chemotherapy is its integration with conventional treatment. Chemotherapeutic agents are employed in the management of cancer to selectively target and eradicate actively proliferating cancerous cells [ 110 – 112 ]. However, it is noteworthy that these medications frequently exert an impact on non-malignant cells as well, hence giving rise to undesirable effects sometimes referred to as side effects.…”

Section: Important Theranostic Features Of Nanoparticlesmentioning

confidence: 99%

Theranostics: a multifaceted approach utilizing nano-biomaterials

Yasir,

Mishra,

Tripathi

et al. 2024

Discover Nano

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Biomaterials play a vital role in targeting therapeutics. Over the years, several biomaterials have gained wide attention in the treatment and diagnosis of diseases. Scientists are trying to make more personalized treatments for different diseases, as well as discovering novel single agents that can be used for prognosis, medication administration, and keeping track of how a treatment works. Theranostics based on nano-biomaterials have higher sensitivity and specificity for disease management than conventional techniques. This review provides a concise overview of various biomaterials, including carbon-based materials like fullerenes, graphene, carbon nanotubes (CNTs), and carbon nanofibers, and their involvement in theranostics of different diseases. In addition, the involvement of imaging techniques for theranostics applications was overviewed. Theranostics is an emerging strategy that has great potential for enhancing the accuracy and efficacy of medicinal interventions. Despite the presence of obstacles such as disease heterogeneity, toxicity, reproducibility, uniformity, upscaling production, and regulatory hurdles, the field of medical research and development has great promise due to its ability to provide patients with personalised care, facilitate early identification, and enable focused treatment.

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Section: Important Theranostic Features Of Nanoparticlesmentioning

confidence: 99%

Theranostics: a multifaceted approach utilizing nano-biomaterials

Yasir,

Mishra,

Tripathi

et al. 2024

Discover Nano

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“…In recent years, researchers have committed to developing nanotechnology-based delivery systems to overcome MDR in tumors. 59 …”

Section: Brief Description Of Bnddsmentioning

confidence: 99%

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han,

Gong,

Yang

et al. 2024

IJN

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With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from the body, and nonspecific targeting, which have hampered their clinical application. Therefore, the development of novel drug delivery systems with improved biocompatibility and high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug delivery system (BNDDS) has become a research hotspot focus in the field of life sciences. This new biomimetic platform uses bio-nanotechnology to encapsulate synthetic NPswithin biomimetic membrane, organically integrating the low immunogenicity, low toxicity, high tumor targeting, good biocompatibility of the biofilm with the adjustability and versatility of the nanocarrier, and shows promising applications in the field of precision tumor therapy. In this review, we systematically summarize the new progress in BNDDS used for optimizing drug delivery, providing a theoretical reference for optimizing drug delivery and designing safe and efficient treatment strategies to improve tumor treatment outcomes.

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“…Despite being one of most conventional disease-treatment methods, chemotherapy suffers from drug resistance and adverse effect arising from off-target activity. [143][144][145][146] Self-assembling peptide-based biomedical materials in living cells represents one promising approach to address these challenges. [147][148][149][150][151] Due to the capability of peptide nanostructures, including nanoparticles, nanofibers, and nanofibrous networks, to interfere in physiological processes, stimulus-activatable peptide assemblies have been directly utilized as therapeutic agents.…”

Section: Chemotherapymentioning

confidence: 99%