Nanometer size wear debris generated from ultrahigh molecular weight polyethylene in vivo

Lapčíková, Monika; Šlouf, Miroslav; Dybal, J.; Zolotarevova, E.; Entlicher, G.; Pokorný, D; Gallo, Jiří; Sosna, A

doi:10.1007/978-3-540-85226-1_384

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…To validate the purity of polyethylene particles, multiple regions of polycarbonate membranes from two patient tissue digests were scanned using Fourier transform infrared (FTIR) Spectroscopy (Nicolet/Thermo Fisher Scientific, Waltham, MA) in transmission and compared with blank membranes. A comparison of the current FTIR findings with previous spectra showed agreement in the vibration peaks for polyethylene 54…”

Section: Methodssupporting

confidence: 81%

Characteristics of highly cross‐linked polyethylene wear debrisin vivo

et al. 2013

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Despite the widespread implementation of highly cross-linked polyethylene (HXLPE) liners to reduce the clinical incidence of osteolysis, it is not known if the improved wear resistance will outweigh the inflammatory potential of HXLPE wear debris generated in vivo. Thus, we asked: What are the differences in size, shape, number, and biological activity of polyethylene wear particles obtained from primary total hip arthroplasty revision surgery of conventional polyethylene (CPE) versus remelted or annealed HXLPE liners? Pseudocapsular tissue samples were collected from revision surgery of CPE and HXLPE (annealed and remelted) liners, and digested using nitric acid. The isolated polyethylene wear particles were evaluated using scanning electron microscopy. Tissues from both HXLPE cohorts contained an increased percentage of submicron particles compared to the CPE cohort. However, the total number of particles was lower for both HXLPE cohorts, as a result there was no significant difference in the volume fraction distribution and specific biological activity (SBA; the relative biological activity per unit volume) between cohorts. In contrast, based on the decreased size and number of HXLPE wear debris there was a significant decrease in total particle volume (mm3/g of tissue). Accordingly, when the SBA was normalized by total particle volume (mm3/gm tissue) or by component wear volume rate (mm3/year), functional biological activity of the HXLPE wear debris was significantly decreased compared to the CPE cohort. Indications for this study are that the osteolytic potential of wear debris generated by HXLPE liners in vivo is significantly reduced by improvements in polyethylene wear resistance.

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Section: Methodssupporting

confidence: 81%

Characteristics of highly cross‐linked polyethylene wear debrisin vivo

et al. 2013

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“…According to Scott et al 48 , this pore size is expected to exclude 2.8% of the total particle number, thereby having a negligible effect on the total particle volume. In addition, Richards et al 49 showed that nanoparticles are rarely observed when a pore size of 0.017 mm is used, a finding that agrees with that of Lapcikova et al 50 , who observed nanoparticles in only two of 100 hiptissue samples from patients. The biological activity of nanoparticles is currently under investigation [51][52][53][54] .…”

Section: Discussionsupporting

confidence: 55%

Severe Impingement of Lumbar Disc Replacements Increases the Functional Biological Activity of Polyethylene Wear Debris

Baxter

MacDonald

Kurtz

et al. 2013

Journal of Bone and Joint Surgery

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“…Studies have shown that exposure to UHMWPE wear debris within a specific size range (0.1–1 μm) results in enhanced macrophage activation in vitro 6, 11–13. In particular, submicron wear debris has been implicated as a potentially important contributor to the onset of osteolysis 6, 14–17. Others have shown the importance of particle number as a major contributor to the development of tissue morphological changes and osteolysis 11, 18, 19.…”

Section: Introductionmentioning

confidence: 99%

“…6,[11][12][13] In particular, submicron wear debris has been implicated as a potentially important contributor to the onset of osteolysis. 6,[14][15][16][17] Others have shown the importance of particle number as a major contributor to the development of tissue morphological changes and osteolysis. 11,18,19 Evaluation of clinical data showed that patients revised for osteolysis consistently had UHMWPE particle quantities in the order of 10 9 particles per gram weight of tissue.…”

Section: Introductionmentioning

confidence: 99%

Distinct immunohistomorphologic changes in periprosthetic hip tissues from historical and highly crosslinked UHMWPE implant retrievals

Baxter¹,

Ianuzzi²,

Freeman³

et al. 2010

J Biomedical Materials Res

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Assessment of immune response to implant wear debris in periprosthetic tissue following total hip arthroplasty suggests that multiple factors are involved in the loss implant function. The current study investigated wear debris and the associated immunohistomorphologic changes in tissues from nine patients with historical (gamma air-sterilized) and nine highly-crosslinked UHMWPE implant components. Paraffin embedded tissue sections were evaluated for the presence of histiocytes, giant cells, fibrocartilage/bone and necrosis. To determine the incidence, degree and co-localization of immunohistomorphologic changes and wear, overlapping full-field tissue arrays were collected in brightfield and polarized light. The historical cohort tissues predominantly showed histiocytes associated with significant accumulations of small wear (0.5–2 μm), and giant cells associated with large wear (≥2 μm). Frequently, focal regions of necrosis were observed in association with wear debris. For the highly-crosslinked cohort, inflammation and associated wear debris were limited, but in tissues from patients revised after implantation times of >2 years a response was observed. Whereas significant amounts of fibrocartilage/bone were observed in patients at earlier implantation times. In both cohorts, tissue responses were more extensive in the retroacetabular or proximal femoral regions. The current findings suggest that wear debris-induced inflammation may be a major contributor to the loss of implant function for both the historical and highly-crosslinked cohorts, but it is not the primary cause of early implant loosening. This study highlights the importance of using a more quantitative and standardized assessment of immunohistomorphologic responses in periprosthetic tissues, and emphasizes differences in specific anatomical regions of individual patient tissues.

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Nanometer size wear debris generated from ultrahigh molecular weight polyethylene in vivo

Cited by 3 publications

References 2 publications

Characteristics of highly cross‐linked polyethylene wear debrisin vivo

Characteristics of highly cross‐linked polyethylene wear debrisin vivo

Severe Impingement of Lumbar Disc Replacements Increases the Functional Biological Activity of Polyethylene Wear Debris

Distinct immunohistomorphologic changes in periprosthetic hip tissues from historical and highly crosslinked UHMWPE implant retrievals

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