2010
DOI: 10.2217/nnm.10.10
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Nanomicellar Formulations for Sustained Drug Delivery: Strategies and Underlying Principles

Abstract: Micellar delivery systems smaller than 100 nm can be readily prepared. While micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. Thus, sustained drug delivery from micellar nanocarriers is a challenge. This article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. Comparisons are made with other competing delivery systems such as polymeric microparticles and nanoparticles… Show more

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Cited by 319 publications
(182 citation statements)
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“…Nanocarriers such as liposomes and polymeric micelles have been used for drug delivery and targeting, thus increasing therapeutic efficacy and minimizing adverse effects at nontarget sites. 5 In the present study, polymeric micelles including LX were fabricated using a simple method and showed a mean diameter of 169.45 nm, with narrow size distribution (PDI =0.243). Furthermore, we studied the therapeutic efficacy of the prepared formula, LX-NM in two classical RA rat models.…”
Section: Discussionmentioning
confidence: 93%
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“…Nanocarriers such as liposomes and polymeric micelles have been used for drug delivery and targeting, thus increasing therapeutic efficacy and minimizing adverse effects at nontarget sites. 5 In the present study, polymeric micelles including LX were fabricated using a simple method and showed a mean diameter of 169.45 nm, with narrow size distribution (PDI =0.243). Furthermore, we studied the therapeutic efficacy of the prepared formula, LX-NM in two classical RA rat models.…”
Section: Discussionmentioning
confidence: 93%
“…These systems are ,200 nm and are designed to encapsulate lipophilic drugs in order to increase drug stability in plasma, enhance tissue penetration and targetability and avoid nonspecific distribution and toxicity. 5 Lornoxicam (LX) is an NSAID of oxicam class. It is a yellow crystalline solid with an acid ionization constant (pKa) of 4.7.…”
Section: Helmy Et Almentioning
confidence: 99%
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“…Nowadays, several examples are under clinical evaluation waiting to promptly become a market reality [14]. These polymeric structures have been described as promising candidates for tumour-targeted therapy as well as non-viral gene vectors [119,120]. Driving forces of one block (hydrophobic or electrostatic interactions, metal complexations or hydrogen bonds) promotes the molecular assembly into core-shell architectures.…”
Section: Drug Deliverymentioning
confidence: 99%
“…Various strategies to solubilize water-insoluble drugs have been tried, which include using cosolvent (Malick et al, 2007) or surfactants (Strickley, 2004), solid dispersion (Janssens and Van den Mooter, 2009), inclusion complex ( Van de Manakker et al, 2009), salt formation (Elder et al, 2010) or colloidal systems such as microemulsion (He et al, 2010), micelles (Trivedi et al, 2010), polymeric nano-/micro-particles (Kumari et. al, 2009 ), liposomes (Cukierman and Khan, 2010), emulsions (Mirtallo et al, 2010) and solid lipid nanoparticles (SLNs) (Souto and Müller, 2010).…”
mentioning
confidence: 99%