Nanomicrobiology

Jain, Kewal K.

doi:10.1007/978-1-4939-6966-1_14

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Quantum dots (QDs): QDs are a promising alternative to traditional methods and an emerging nanotechnology tool for the sensitive diagnosis of bacterial infections [68]. Specifically, QDs have been shown to be capable of detecting S. aureus through a quick and efficient process in which the QD acts as a biosensor that can be modified with S. aureusspecific antibodies to improve the specificity.…”

Section: Use Of Nanotechnology In Diagnosis Of Osteomyelitismentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

et al. 2022

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Infection remains one of the largest threats to global health. Among those infections that are especially troublesome, osteomyelitis, or inflammation of the bone, typically due to infection, is a particularly difficult condition to diagnose and treat. This difficulty stems not only from the biological complexities of opportunistic infections designed to avoid the onslaught of both the host immune system as well as exogenous antibiotics, but also from changes in the host vasculature and the heterogeneity of infectious presentations. While several groups have attempted to classify and stage osteomyelitis, controversy remains, often delaying diagnosis and treatment. Despite a host of preclinical treatment advances being incubated in academic and company research and development labs worldwide, clinical treatment strategies remain relatively stagnant, including surgical debridement and lengthy courses of intravenous antibiotics, both of which may compromise the overall health of the bone and the patient. This manuscript reviews the current methods for diagnosing and treating osteomyelitis and then contemplates the role that nanotechnology might play in the advancement of osteomyelitis treatment.

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Section: Use Of Nanotechnology In Diagnosis Of Osteomyelitismentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

et al. 2022

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Antibacterial Assessment of Zinc Sulfide Nanoparticles againstStreptococcus pyogenesandAcinetobacter baumannii

Morshedtalab¹,

Rahimi²,

Emami-Nejad

et al. 2020

CTMC

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Background: Due to the appearance of resistant bacterial strains against the antimicrobial drugs and the reduced efficiency of these valuable resources, the health of a community and the economies of countries have been threatened. Objective: In this study, the antibacterial assessment of zinc sulfide nanoparticles (ZnS NPs) against Streptococcus pyogenes and Acinetobacter baumannii has been performed. Methods: ZnS NPs were synthesized through a co-precipitation method using polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG-4000). The size and morphology of the synthesized ZnS NPs were determined by a scanning electron microscope (SEM) and it was found that the average size of the applied NPs was about 70 nm. In order to evaluate the antibacterial effect of the synthesized ZnS NPs, various concentrations (50μg/mL, 100 μg/mL and 150 μg/mL) of ZnS NPs were prepared. Antibacterial assessments were performed through the disc diffusion method in Mueller Hinton Agar (MHA) culture medium and also the optical density (OD) method was performed by a UV-Vis spectrophotometer in Trypticase™ Soy Broth (TSB) medium. Then, in order to compare the antibacterial effects of the applied NPs, several commercial antibiotics including penicillin, amikacin, ceftazidime and primaxin were used. Results: The achieved results indicated that the antibacterial effects of ZnS NPs had a direct relation along with the concentrations and the concentration of 150 μg/mL showed the highest antibacterial effect in comparison with others. In addition, the ZnS NPs were more effective on Acinetobacter baumannii. Conclusion: The findings of this research suggest a novel approach against antibiotic resistance.

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Nanomicrobiology

Cited by 2 publications

References 37 publications

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

Antibacterial Assessment of Zinc Sulfide Nanoparticles againstStreptococcus pyogenesandAcinetobacter baumannii

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