2019
DOI: 10.3390/biom9050202
|View full text |Cite
|
Sign up to set email alerts
|

Nanoparticle Activation Methods in Cancer Treatment

Abstract: In this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-target effects. This has led to the development of smart nanosystems which can effect specific regional and temporal activation. In this review, we will discuss the different methodologies which have been designed to per… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
27
0
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 31 publications
(29 citation statements)
references
References 128 publications
(173 reference statements)
1
27
0
1
Order By: Relevance
“…On top of passive accumulation, tumor eradication could be improved by active targeting. In the past, nanoparticles have been designed with pH-responsive activity, making use of the altered pH-environment within cells with enhanced metabolism, especially cancer cells [65,66]. Since many tumors have also shown altered enzyme expression, similar effects can be achieved by nanoparticles that are enzyme-triggered and activated specifically at the tumor site [67,68].…”
Section: Discussionmentioning
confidence: 99%
“…On top of passive accumulation, tumor eradication could be improved by active targeting. In the past, nanoparticles have been designed with pH-responsive activity, making use of the altered pH-environment within cells with enhanced metabolism, especially cancer cells [65,66]. Since many tumors have also shown altered enzyme expression, similar effects can be achieved by nanoparticles that are enzyme-triggered and activated specifically at the tumor site [67,68].…”
Section: Discussionmentioning
confidence: 99%
“…These are diverse molecular structures, including lipid micelles, liposome composites of phospholipid and other molecules, and polymer-based particles, with the common property that they form a vesicle that can be loaded with therapeutic agents and which can then cross the BBB to enter the parenchyma ( 226 ). Once within the brain, variation in environmental pH at the tumor site, amongst other conditions destabilize the nanocarrier structure and trigger release of the cargo within the tissue ( 227 ). Although effective, these nanocarriers are indiscriminate and passively deliver their cargo widely across the brain, a drawback that has spurred the development of more effectively targeted nanocarrier delivery systems.…”
Section: Overcoming Gbm-driven Immunosuppressionmentioning
confidence: 99%
“…This characteristic is globally recognized as an advantageous opportunity to promote passive tumor accumulation of nanoparticles and to facilitate their cellular uptake, depending on the nanoparticles physicochemical properties [148,149]. Moreover, compared to healthy tissues, tumor microenvironment has unique physicochemical features, including hypoxia, slightly acidic pH, active efflux pumps, hyperthermia and overexpression of several molecular biomarkers [150,151,152]. Considering this, a locally triggered drug release from nanosystems may be promoted by taking advantage of these intrinsic tumor biological peculiar conditions (e.g., pH, temperature and enzymes) or through the application of external stimuli (e.g., light, electric fields, magnetic fields or ultrasound) [144,152,153,154,155,156,157].…”
Section: Nanotechnology and Cancer Treatment—tackling Melanomamentioning
confidence: 99%