Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterization of a promising drug delivery system

Stein, Nora C.; Mulac, Dennis; Fabian, Jörg; Herrmann, Fabian; Langer, Klaus

doi:10.1016/j.ijpharm.2020.119347

Cited by 16 publications

(12 citation statements)

References 28 publications

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“…The formation of nanoparticle pockets enhanced the encapsulation property of the system. Stein et al [ 102 ] studied the preparation of stable mTHPC-albumin nanoparticles using nanoparticle albumin-bound (nab)-technology to develop a system for drugs that are not very water-soluble. In this study, the advantages of nanotechnology and albumin with the ability of high tumor enrichment and the selective light initiation of the photosensitizer Temoporfin (mTHPC) were associated with a new delivery system for reliable tumor treatment.…”

Section: Albumin-based Nanoparticlesmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

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Section: Albumin-based Nanoparticlesmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Section: Nanoparticle Albumin Bound Technologymentioning

confidence: 99%

“…Specifically, Temoporfin (mTHPC), a photosensitizer, was incorporated into the Nab system to mitigate prolonged infusion rates and adverse side effects with the commercially available Foscan, which is formulated with ethanol and propylene glycol. [66] In summary, Nab technology is a fabrication method of albumin nanoparticles encapsulating hydrophobic drugs through a combination of high shear, cavitation, and pressure. Nab technology is the first commercialized nanomedicine (Abraxane) after FDA approvement in 2005.…”

Section: Water Miscible Organic Solventmentioning

confidence: 99%

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Habibi

Mauser

et al. 2022

Advanced Science

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Protein nanoparticles, PNPs, have played a long‐standing role in food and industrial applications. More recently, their potential in nanomedicine has been more widely pursued. This review summarizes recent trends related to the preparation, application, and chemical construction of nanoparticles that use proteins as major building blocks. A particular focus has been given to emerging trends related to applications in nanomedicine, an area of research where PNPs are poised for major breakthroughs as drug delivery carriers, particle‐based therapeutics or for non‐viral gene therapy.

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“…Stein et al formulated mTHPC-albumin nanoparticles using nab-technology [169]. Nanoparticles showed colloidal stability over a wide range of pH and in physiological NaCl with different concentrations.…”

Section: Encapsulation Of Biologicsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part II - Polysaccharides and Proteins

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Encapsulation remains a fundamental and consistent approach of fabrication of drug and diagnostic delivery systems in the health space and natural polymers such as polysaccharides and proteins continue to play significant roles. Micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, or biologics, bioactives from natural sources and diagnostics such as biomarkers. The outcome of any encapsulation depends on the technique employed and the encapsulating material. The encapsulating materials employed influence the physical and chemical attributes of the fabricated micro- and nanocapsules. The encapsulating materials could be natural or synthetic, however, natural polymers are preferred because they are human and environmentally friendly. Polysaccharides and proteins are abundant in nature, biogenic, biocompatible, biodegradable and possess biological functions making them materials of choice for encapsulation of drugs and diagnostics. This chapter reviews the recent and advanced applications of polysaccharides and proteins as nanocarrier materials for micro- and nanoencapsulation of therapeutics and diagnostics.

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Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterization of a promising drug delivery system

Cited by 16 publications

References 28 publications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part II - Polysaccharides and Proteins

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