Nanoparticle Based CT Contrast Agents

Charmi, Jalil; Salehiabar, Marziyeh; Ghaffarlou, Mohammadreza; Danafar, Hossein; Kavetskyy, Taras; Davaran, Soodabeh; Ertaş, Yavuz Nuri; Sharma, S. K.; Nosrati, Hamed

doi:10.1007/978-3-031-04071-9_8

Cited by 1 publication

(1 citation statement)

References 91 publications

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“…Nowadays, scintillation underlies a myriad of technologies, spanning diagnostic medical imaging, radiation therapy, security inspection tools, environmental radiation monitoring, high energy astrophysics, and interplanetary space missions. Scintillators play a prominent role in bioimaging and biomedicine [ 6 ]–[ 8 ] including gamma cameras, single photon emission computed tomography (SPECT), positron emission tomography (PET), X-ray induced photo dynamic therapy (X-PDT) [ 9 ]–[ 11 ], and intraoperative imaging enabling radioguided surgical procedures [ 12 ]. In gamma cameras, SPECT and PET, scintillators are the major detection unit to record and spatially correlate high energy photons to produce images of the radionuclide distribution.…”

Section: Introductionmentioning

confidence: 99%

Toward “super-scintillation” with nanomaterials and nanophotonics

Carr Delgado,

Moradifar,

Chinn

et al. 2024

Nanophotonics

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Following the discovery of X-rays, scintillators are commonly used as high-energy radiation sensors in diagnostic medical imaging, high-energy physics, astrophysics, environmental radiation monitoring, and security inspections. Conventional scintillators face intrinsic limitations including a low extraction efficiency of scintillated light and a low emission rate, leading to efficiencies that are less than 10 % for commercial scintillators. Overcoming these limitations will require new materials including scintillating nanomaterials (“nanoscintillators”), as well as new photonic approaches that increase the efficiency of the scintillation process, increase the emission rate of materials, and control the directivity of the scintillated light. In this perspective, we describe emerging nanoscintillating materials and three nanophotonic platforms: (i) plasmonic nanoresonators, (ii) photonic crystals, and (iii) high-Q metasurfaces that could enable high performance scintillators. We further discuss how a combination of nanoscintillators and photonic structures can yield a “super scintillator” enabling ultimate spatio-temporal resolution while enabling a significant boost in the extracted scintillation emission.

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