2020
DOI: 10.1016/j.nano.2020.102182
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Nanoparticle-based immunomagnetic assay of plasma biomarkers for differentiating dementia and prodromal states of Alzheimer's disease – A cross-validation study

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Cited by 20 publications
(26 citation statements)
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“…Our findings revealed that in this current mixed neurodegenerative population, Aβ42 plasma levels increased in patients with AD compared to MCI and controls. Besides, Aβ42 plasma levels were higher in MCI than those in controls compatible with a previous study, suggesting that Aβ42 plasma levels can differentiate healthy control from subjects with MCI [ 23 ]. From a pathological point of view, Aβ deposition plateaus when patients progress into the clinical MCI phase of AD at the time of cognitive symptoms [ 24 ].…”
Section: Discussionsupporting
confidence: 89%
“…Our findings revealed that in this current mixed neurodegenerative population, Aβ42 plasma levels increased in patients with AD compared to MCI and controls. Besides, Aβ42 plasma levels were higher in MCI than those in controls compatible with a previous study, suggesting that Aβ42 plasma levels can differentiate healthy control from subjects with MCI [ 23 ]. From a pathological point of view, Aβ deposition plateaus when patients progress into the clinical MCI phase of AD at the time of cognitive symptoms [ 24 ].…”
Section: Discussionsupporting
confidence: 89%
“…Significantly lower plasma Aβ42/40 ratios have been reported in both MCI and AD as compared with CU [64,[84][85][86][87][88]. However, the primary outcome of these plasma Aβ studies has predominately been to detect Aβ positivity.…”
Section: Phase 2: Primary Aimmentioning
confidence: 99%
“…In studies utilizing IMR published so far [7][8][9][10][11][12][13][14], the concentration of plasma samples of Ab 1-40 , [12,13]. Ab 1-42 9 T-Tau or Ab 1-42 /Ab 1-40 in plasma has been shown to discriminate NCs from subjects with aMCI and AD [8][9][10].…”
Section: Discussionmentioning
confidence: 99%
“…A total of 242 subjects were enrolled from the memory clinics of the Taipei Medical University Shuang-Ho Hospital, the Renai Branch of Taipei City Hospital, the En Chu Kong Hospital and the National Taiwan University Hospital (master), from 2015 to 2016 [ 14 ]. Exclusion criteria were neurologic diseases that affect brain structure, such as epilepsy head injury or stroke; medical diseases involving cardiopulmonary failure; hepatic or renal failure; and poor control of diabetes (HbA1c > 8.5).…”
Section: Methodsmentioning
confidence: 99%
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