Nanoparticle-based optical sensor arrays

Abstract

As in many other methods that have integrated nanoparticles (NPs), the chemical nose/tongue strategy has also progressed greatly since the entrance of NPs into this field. The fascinating tunable physicochemical properties of NPs have made them powerful candidates for array-based sensing platforms and have enabled the development of real-time, sensitive and portable systems that are able to target complex mixtures of analytes. In particular, the unique optical properties of NPs have a key role in providing promising array-based sensing approaches. This review will describe the main aspects and processes of most common NP-based optical sensor arrays. The fundamental steps in the design of a sensor array together with details of each step would be provided. The review begins with the principles of optical sensor arrays and presents the concept of cross-reactivity as the main criterion in the selection of sensing elements. Changes in the absorption and emission properties of the assembled sensing elements are categorized into two main classes of optical signals (colorimetric and fluorometric). Popular chemometric methods used for analyzing the data acquired by a sensor array have also been briefly introduced. On the basis of the objective and the desired application, different types of plasmonic and fluorescent NP that possess unique opto-physical properties have been presented as available choices in the design of sensing elements. The vast number of applications of NP-based optical sensor arrays published throughout the literature have then been reviewed according to their mechanism of interaction and the type of optical signal. Finally, the remaining challenges and future directions in this topic have been highlighted.

Array‐basierte Sensorik mit der “chemischen Nase” in der Diagnostik und Wirkstoffentdeckung

“…Nanomaterialien sind besonders nützlich für die Biosensorik wegen ihrer einzigartigen physikochemischen Eigenschaften, die für neuartige Erkennungs‐ und Transduktionsprozesse verwendet werden können . Nanopartikel sind stark regelbar in Bezug auf ihre Größe und Oberfläche, wobei ein oder mehrere Liganden als Erkennungselemente fungieren können .…”

The Ability of Ginger Rhizome (Zingiber officinale Rosc) Extract in Producing of Silver Nanoparticles and the Antibacterial activity of these nanoparticles

“…Địa chỉ email: ndthang@hus.edu.vn https://doi.org/10.25073/2588-1140/vnunst.4922 điểm vật lý, hóa học và sinh học so với vật liệu truyền thống do sự thu nhỏ kích thước và việc tăng diện tích bề mặt [1]. Do có nhiều tính năng độc đáo và kích thước tương đương với các phân tử sinh học nên hiện nay, công nghệ nano đang được đầu tư nghiên cứu và được ứng dụng trong nhiều lĩnh vực, đặc biệt là lĩnh vực y sinh [2][3][4].…”

Fingerprint-based Protein Identification in Cell Culture Medium Using Environment-sensitive Turn-on Fluorescent Polymer

“…Fingerprint-based sensing techniques provide a promising alternative approach to protein sensing. (7,8) In contrast to the specific recognition of antibodies, this approach is based on "cross-reactive" interactions of a probe array against analyte proteins. Such probe arrays are constructed to exhibit the chemical diversity necessary to respond distinctively to a variety of analyte proteins, allowing the generation of target-specific response fingerprints.…”

“…This strategy has been used to identify proteins dissolved in buffer solutions, (9)(10)(11)(12) serum, (13)(14)(15)(16) and urine. (17,18) Most of the previously reported fingerprint-based sensors, however, require multiple synthetic probes as sensor elements for the construction of an array with reliable discrimination ability, (7,8) which involves laborious synthetic efforts.…”