Nanoparticle contrast agents for X‐ray imaging applications

Hsu, Jessica C.; Nieves, Lenitza M.; Betzer, Oshra; Sadan, Tamar; Noël, Peter B.; Popovtzer, Rachela; Cormode, David P.

doi:10.1002/wnan.1642

Cited by 98 publications

(78 citation statements)

References 220 publications

(310 reference statements)

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“…However, micron‐sized metal‐oxides and metal complex additions into the dental materials can cause late‐type hypersensitivity reactions (Gawkrodger, 2005; Stejskal & Stejskal, 1999; Syed, Chopra, & Sachdev, 2015). Bar suspensions have been used safely in clinical medicine since the 1950s (Hsu et al, 2020; Oliva et al, 2012). Similarly, the high atomic number of Bi brings about a high energy radiation attenuation larger than that of lead at almost negligible risk of toxicity (Bartoli, Jagdale, & Tagliaferro, 2020).…”

Section: Discussionmentioning

confidence: 99%

Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA

Orhan

Irmak²,

Bal

et al. 2020

Microscopy Res & Technique

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The aim of this article was to investigate the unknown radiopacity performances of OrthoMTA and RetroMTA via means of a contemporary image analyzing methods and energy dispersive X-ray spectroscopy. Three commercial hydraulic calcium silicate-based cements and a calcium hydroxide-based paste were used. Pure-grade zirconium oxide, bismuth oxide, zinc oxide, barium sulfate, and calcium hydroxide were as references. An energy-dispersive X-ray spectroscopy instrument was used for the elemental analysis. Radiographic image data was obtained according to the International Organization for Standardization 6876-2012 specifications. The region of interest was determined for each specimen. Mean (±SD) grey values of the X-ray image data was measured with an image analyzing software. The calibration curve was created by curve-plotting software and the mean grey-values were matched versus Al values (mm Al). Data were analyzed with one-way ANOVA followed by Tukey's multiple comparison test. Spectroscopic characterization of the commercial materials was shown with assigned Carbon, oxygen, aluminum, silicon, calcium, zinc, zirconium, barium, tungsten, bismuth, and sulfur elements. The major radiopacifier/s of OrthoMTA is Bi, of RetroMTA is Zr, of BioDentine are Ba and Zr, and of ProCal is Ba. The radiopacity values of all commercial materials are significantly different (p < .05). The rank of the radiopacity values: RetroMTA (3.36 ± 0.29mmAl) > OrthoMTA (2.56 ± 0.19mmAl) > BioDentine (2.02 ± 0.12mmAl) > ProCal (1.46 ± 0.60mmAl). The study reported that the radiopacity values and spectral characterization of RetroMTA and OrthoMTA cements. The pixel-based and reproducible method could be used universally to the quantification of the radiodensity of digitally collected X-ray data.

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Section: Discussionmentioning

confidence: 99%

Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA

Orhan

Irmak²,

Bal

et al. 2020

Microscopy Res & Technique

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“…However, the poor soft tissue contrast of CT mandates the use of X-ray attenuating contrast media for a number of applications. In the last two decades, a variety of nanoparticle contrast agents for X-ray imaging have been developed 16 , 17 . These nanoparticles can enter cells by phagocytosis, which takes place mainly in professional phagocytes, cells from the mononuclear phagocytic system (MPS), such as macrophages 18 , 19 .…”

Section: Introductionmentioning

confidence: 99%

Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm

Toczek¹,

Boodagh²,

Sanzida³

et al. 2021

Theranostics

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Inflammation plays a major role in the pathogenesis of several vascular pathologies, including abdominal aortic aneurysm (AAA). Evaluating the role of inflammation in AAA pathobiology and potentially outcome in vivo requires non-invasive tools for high-resolution imaging. We investigated the feasibility of X-ray computed tomography (CT) imaging of phagocytic activity using nanoparticle contrast agents to predict AAA outcome. Methods: Uptake of several nanoparticle CT contrast agents was evaluated in a macrophage cell line. The most promising agent, Exitron nano 12000, was further characterized in vitro and used for subsequent in vivo testing. AAA was induced in Apoe -/- mice through angiotensin II (Ang II) infusion for up to 4 weeks. Nanoparticle biodistribution and uptake in AAA were evaluated by CT imaging in Ang II-infused Apoe -/- mice. After imaging, the aortic tissue was harvested and used from morphometry, transmission electron microscopy and gene expression analysis. A group of Ang II-infused Apoe -/- mice underwent nanoparticle-enhanced CT imaging within the first week of Ang II infusion, and their survival and aortic external diameter were evaluated at 4 weeks to address the value of vessel wall CT enhancement in predicting AAA outcome. Results: Exitron nano 12000 showed specific uptake in macrophages in vitro . Nanoparticle accumulation was observed by CT imaging in tissues rich in mononuclear phagocytes. Aortic wall enhancement was detectable on delayed CT images following nanoparticle administration and correlated with vessel wall CD68 expression. Transmission electron microscopy ascertained the presence of nanoparticles in AAA adventitial macrophages. Nanoparticle-induced CT enhancement on images obtained within one week of AAA induction was predictive of AAA outcome at 4 weeks. Conclusions: By establishing the feasibility of CT-based molecular imaging of phagocytic activity in AAA, this study links the inflammatory signal on early time point images to AAA evolution. This readily available technology overcomes an important barrier to cross-sectional, longitudinal and outcome studies, not only in AAA, but also in other cardiovascular pathologies and facilitates the evaluation of modulatory interventions, and ultimately upon clinical translation, patient management.

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“…Some other researches have stated that the signal-to-noise ratio of rhenium sulfide nanoparticle contrast agent is higher than that of iodine contrast agent, and the use of rhenium sulfide nanoparticle contrast agent in CT imaging can improve the contrast of gastrointestinal imaging in patients [21]. At present, the common CTA nanocontrast agents include nano suspensions, micelles, and nano latexes [22][23][24]. Metal nanoparticles have excellent quantum size effects, volume effects, and surface effects and are widely used in many fields such as catalysts, medical materials, and electromagnetic functional materials [25,26].…”

Section: Discussionmentioning

confidence: 99%

The Value of CTA Based on Gold Nanorod Contrast Agent in Coronary Artery Diagnosis and Plaque Property Analysis

Wang

et al. 2021

Computational and Mathematical Methods in Medicine

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Coronary CT angiography (CTA) with the characteristics of noninvasive and simple operation is widely used in the diagnosis of coronary artery stenosis. The choice of contrast agent exerts an important impact on the imaging quality of CTA. Conventional iodine contrast agents are easily excreted by the kidneys, from which the imaging window is short, and the imaging quality is poor. Metal nanomaterials have unique optical properties and have broad application prospects in imaging. Our aim is to explore the value of gold nanorod contrast agent in the diagnosis of coronary heart disease. A gold nanorod suspension was first prepared, and the prepared gold nanorod was uniform and had good dispersibility. It can be seen from the light absorption curve that there are two obvious peaks on the UV absorption peak of the gold nanorods. The gold nanorods were cultured in different solutions, and it was found that the particle size of the gold nanorods did not change significantly within 72 hours, indicating that the prepared gold nanorods had good stability. When observing the damage degree of mouse kidney tissue, it was shown that the damage degree of gold nanorod contrast agent to mouse kidney tissue was less than that of iodine contrast agent. The above results indicate that the gold nanorod contrast agent has good stability and safety. Therefore, our study demonstrated that the gold nanorod contrast agent has high value in the diagnosis of coronary arteries and the analysis of plaque properties.

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Nanoparticle contrast agents for X‐ray imaging applications

Cited by 98 publications

References 220 publications

Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA

Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA

Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm

The Value of CTA Based on Gold Nanorod Contrast Agent in Coronary Artery Diagnosis and Plaque Property Analysis

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