Nanoparticle decoration with surfactants: Molecular interactions, assembly, and applications

Heinz, Hendrik; Pramanik, Chandrani; Heinz, Özge; Ding, Yifu; Mishra, Ratan K.; Marchon, Delphine; Flatt, Robert J.; Estrela‐Lopis, Irina; Llop, Jordi; Moya, Sergio; Ziolo, Ronald F.

doi:10.1016/j.surfrep.2017.02.001

Cited by 493 publications

(328 citation statements)

References 513 publications

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“…Nanoparticles have shown great potential for biomedical applications such as drug delivery and antitumor therapeutics . To increase the targeting efficiency, the size, conformation, and surface properties of nanoparticles have been optimized . However, when nanoparticles flow through the bloodstream, they interact with various plasma proteins, leading to the formation of the protein layer on top of the particle surface, a process called protein corona .…”

Section: Introductionmentioning

confidence: 99%

Effects of Nanoparticle Electrostatics and Protein–Protein Interactions on Corona Formation: Conformation and Hydrodynamics

Lee

2020

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All‐atom molecular dynamics simulations of plasma proteins (human serum albumin, fibrinogen, immunoglobulin gamma‐1 chain‐C, complement C3, and apolipoprotein A‐I) adsorbed onto 10 nm sized cationic, anionic, and neutral polystyrene (PS) particles in water are performed. In simulations of a single protein with a PS particle, proteins eventually bind to all PS particles, regardless of particle charge, in agreement with experiments showing the binding between anionic proteins and particles, which is further confirmed by calculating the binding free energies from umbrella sampling simulations. Simulations of mixtures of multiple proteins and a PS particle show the formation of the protein layer on the surface via the adsorption competition between proteins, which influences the binding affinity and structure of adsorbed proteins. In particular, diffusivities are much higher for proteins bound to the particle surface or to the boundary of the protein layer than for those bound to both the particle surface and other proteins, indicating the dependence of protein mobility on their positions in the layer. These findings help to explain in detail experimental observations regarding the replacement of plasma proteins at the early stage of corona formation and the difference in the binding strength of proteins in inner and outer protein‐layers.

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Section: Introductionmentioning

confidence: 99%

Effects of Nanoparticle Electrostatics and Protein–Protein Interactions on Corona Formation: Conformation and Hydrodynamics

Lee

2020

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“…Structures of ILs‐water mixtures are strongly dependent on the choice of the anion and cation. BF 4 − ion containing imidazolium based ILs show hydrophilic properties, and their hydrophilicity decreases with increasing the alkyl chain lengths of the imidazolium ring . Therefore, in IL‐water mixture, water pool formation increases with longer alkyl chain of IL.…”

Section: Resultsmentioning

confidence: 99%

Development of an Ionic Liquid Based Method for the Preparation of Albumin Nanoparticles

Demirkurt

Akdoğan

2018

ChemistrySelect

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Albumin based nanocarriers have been widely used in drug delivery studies. Here, we developed a water‐in‐ionic liquid (IL) emulsion‐like method to prepare bovine serum albumin (BSA) nanoparticles as alternative to the traditional organic solvents containing techniques. Conformational changes of albumin induced by the imidazolium based ILs at the water‐IL interface triggers the BSA nanoparticle formation. The albumin nanoparticle formation are dependent on the experimental parameters and the hydophobicity of the IL. At pH 9.0, using 1.3%wt of BSA in water/1‐butyl‐3‐methyl imidazolium tetrafluoroborate (BmimBF4) (50/50 mol%) and TX‐100/butanol surfactant mixture yields uniformly distributed 200 nm average sized BSA nanoparticles. Different than BmimBF4, using a more hydrophilic IL, EmimBF4 yielded albumin aggregates. Instead, using a more hydrophobic IL, HmimBF4 produced albumin nanoparticles but a non‐uniform size distribution was obtained. These results indicate that the ionic liquids called green and designer solvents can be also used to synthesize albumin nanoparticles.

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“…Additionally,t he high surface-to-volume ratio of these NPs with an active surfacep rovides better attachment and identification of bio-/chemical analytes. [25] Lorentz-Mie theory [26] wasu sed for the theoretical calculation of the plasmonic resonanceo fM NPs. By using Equations (1), (2), (3), (4), and (5), total extinction (Q ext )a nd scattering efficiency (Q sca )f or ah omogenouss pherec an be estimated:…”

Section: Fundamental Properties Of Mnps As Label-free Biosensorsmentioning

confidence: 99%

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

et al. 2019

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Label‐free biosensors offer accurate sensing capabilities due to the reliable quantification of biological and biochemical processes. These devices function by establishing a dynamic interaction of analyte and receptor molecules and convert this interaction into a measurable signal through a transducer. In recent decades, label‐free biosensors have attracted attention in biomedical applications due to the ease of linking nanomaterials with bioreceptor molecules. In this review, recent advances in sensitivity, specificity, and sensing mechanism related to label‐free biosensors of metallic nanoparticles of gold, silver, aluminium, copper, and zinc oxide are presented. Selected sensing methods based on fluorescence, surface plasmon resonance, surface‐enhanced Raman scattering, metal‐enhanced fluorescence, and electrochemical sensors are discussed. New measurement techniques and rapid progress of label‐free biosensors are going to play a vital role in the real‐time detection of biomarkers in clinical samples, such as blood plasma, serum, and urine, as well as in targeted drug delivery. Future trends of these label‐free biosensing mechanisms and their development are also discussed.

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Nanoparticle decoration with surfactants: Molecular interactions, assembly, and applications

Cited by 493 publications

References 513 publications

Effects of Nanoparticle Electrostatics and Protein–Protein Interactions on Corona Formation: Conformation and Hydrodynamics

Effects of Nanoparticle Electrostatics and Protein–Protein Interactions on Corona Formation: Conformation and Hydrodynamics

Development of an Ionic Liquid Based Method for the Preparation of Albumin Nanoparticles

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

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