Nanoparticle distribution and temperature elevations in prostatic tumours in mice during magnetic nanoparticle hyperthermia

Abstract

Among a variety of hyperthermia methods, magnetic nanoparticle hyperthermia is a highly promising approach for its confined heating within the tumour. In this study we perform in vivo animal experiments on implanted prostatic tumours in mice to measure temperature distribution in the tumour during magnetic nanoparticle hyperthermia. Temperature elevations are induced by a commercially available ferrofluid injected via a single injection to the centre of the tumour, when the tumour is subject to an alternating magnetic field. Temperature mapping in the tumours during magnetic nanoparticle hyperthermia has demonstrated the feasibility of elevating tumour temperatures higher than 50°C using only 0.1 cm(3) ferrofluid injected in the tumour under a relatively low magnetic field (3 kA/m). Detailed 3-D nanoparticle concentration distribution is quantified using a high-resolution microCT imaging system. The calculated nanoparticle distribution volume based on the microCT scans is useful to analyse nanoparticle deposition in the tumours. Slower ferrofluid infusion rates result in smaller nanoparticle distribution volumes in the tumours. Nanoparticles are more confined in the vicinity of the injection site with slower infusion rates, causing higher temperature elevations in the tumours. The increase in the nanoparticle distribution volume in the tumour group after the heating from that in the tumour group without heating suggests possible nanoparticle re-distribution in the tumours during the heating.

γ-Fe2O3 nanoparticles filled polyvinyl alcohol as potential biomaterial for tissue engineering scaffold

“…Blending with other biomaterials is one way towards this and is of interest in this study. Magnetic nanoparticles which have been used in biomedical applications (Arbab et al, 2003;Wilhelm et al, 2003;Shimizu et al, 2007;Attaluri et al, 2011;Akiyama et al, 2010) such as cell sheet construction, cell expansion, magnetic cell seeding, cancer hyperthermia treatment, and drug delivery vehicle can be a possible option to enhance the properties of PVA when blended with it. Availability of magnetic nanoparticles within PVA scaffold will also increase its rigidity favourably (Shao et al, 2013;Idris et al, 2012).…”

Thermofluid Analysis in Magnetic Hyperthermia Using Low Curie Temperature Particles

“…Different ferrofluid volumes: = 0.1 − 0.3 cm 3 with a concentration = 3.3% by volume were injected within IS with different infusion rates: 10 − 35µl/min. These small amounts of ferrofluid are clinically realistic [14]. The temperature field within tumor and healthy tissue was computed using: i) the temperature dependent power density experimentally obtained, in the relations (5) and (6) and ii) the spatial distribution of the particles as solution of equation (4).…”

“…The heat sources of the tumor represented by the MPs particles are distributed within tumor. The mass density ( 1 ), specific heat ( 1 ) and thermal conductivities ( 1 ) of tumor depend on the particle volume fraction injected within tumor ∅ 1 = 1 , , [13,14]:…”

“…2 The temperature dependent power density of the particles computed from experimental data [5] High values of the thermal conductivity and specific heat capacity allow a good heat transfer from the particles to the tissues. The temperature field within tumor (i =1) and healthy tissue (i = 2) is given by the solution = , , , of the Pennes bioheat equation with proper thermal boundary conditions at tumor -healthy tissue interface [12,14]:…”

A capillary viscometer designed for the characterization of biocompatible ferrofluids

“…This approach involves a heating of the ferrofluids' nanoparticles by the application of an external magnetic AC field, damaging or destructing potentially diseased cells [13][14][15]. The ability of MFH to aid in the treatment of cancer has been shown in several studies up to now (e.g., [16][17][18]). …”