Nanoparticle-enabled terahertz imaging for cancer diagnosis

Oh, Seung Jae; Kang, Jinyoung; Maeng, Inhee; Suh, Jin Suck; Huh, Yong Min; Haam, Seungjoo; Son, Joo‐Hiuk

doi:10.1364/oe.17.003469

Cited by 164 publications

(102 citation statements)

References 17 publications

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“…The change in the THz response is due to the activation of the surface plasmon resonance on the surface of nanoparticle probes when illuminated with NIR beams. The development of a differential measurement technique in which the NIR beam is directly modulated instead of numerical subtraction of two images led to high signal-to-noise ratio (SNR) eliminating the background noise and generating a high sensitivity capable of identifying the miniscule differences at a cellular level [399].…”

Section: Gold Nanoobjectsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Section: Gold Nanoobjectsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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“…Conventional THz imaging for cancer diagnosis assesses the difference in water content or structural changes between tumor and normal tissues. However, the use of THMI nanoprobes improved the sensitivity of the conventional THz imaging by providing a target-specific THz image and by enabling the assessment of molecular and cellular activities via the analysis of THz waveforms [398,399] . The sensitivity of THz electromagnetic (EM) waves to water molecules allows the utilization of the THz technique in diagnosing cancers because in cancerous tumors, diseased tissues contain more interstitial water than healthy tissues.…”

Section: Terahertz Molecular Imaging (Thmi)mentioning

confidence: 99%

“…The change in the THz response is due to the activation of the surface plasmon resonance on the surface of NP probes when illuminated with NIR beams. The development of a differential measurement technique in which the NIR beam is directly modulated instead of numerical subtraction of two images led to high SNR eliminating the background noise and generating a high sensitivity capable of identifying the miniscule differences at a cellular level [399] .…”

Section: Gold Nanoobjectsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Terahertz (THz) electromagnetic waves are highly sensitive to biomolecules and water content, hence they have applied to many biomedical applications [1][2][3][4][5][6][7][8][9][10]. For example, the application of THz spectroscopic imaging to cancer diagnosis has been investigated [11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…We didn't use any limiting aperture and the spatial resolution of our system was roughly 0.8-mm at 0.5 THz. The incident angle of THz beams focused through a quartz window was 14.6° [5,9]. A fast optical delay line (APE) with 20 Hz operating frequency and 37 ps time window was used for fast acquisition of THz signals.…”

Section: Introductionmentioning

confidence: 99%

Terahertz spectroscopic imaging and properties of gastrointestinal tract in a rat model

Kim

Jeong

et al. 2014

Biomed. Opt. Express

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Abstract:We have investigated basic properties of normal gastrointestinal (GI) tract tissues, including glandular stomach (GS), fore stomach (FS), large intestine (LI), small intestine (SI), and esophagus (ESO), from a rat model using terahertz (THz) reflection imaging and spectroscopy. The THz images collected from stratified squamous epithelia (SSE) of FS and ESO show a lower peak-to-peak value compared to those from columnar epithelia (CE) of GS, LI, or SI because the SSE contains less water than CE. The refractive index and absorption coefficient of FS were less than those of GS or LI, both having values similar to those of water. Additionally, we report internal reflection THz signals from ESO, although we were unable to determine the exact interface for this internal reflection.

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Nanoparticle-enabled terahertz imaging for cancer diagnosis

Cited by 164 publications

References 17 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Terahertz spectroscopic imaging and properties of gastrointestinal tract in a rat model

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