Nanoparticle–hydrogel superstructures for biomedical applications

Jiang, Yao; Krishnan, Nishta; Heo, Jiyoung; Fang, Ronnie H.; Zhang, Liangfang

doi:10.1016/j.jconrel.2020.05.041

Cited by 164 publications

(122 citation statements)

References 178 publications

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“…In particular, the utility of hydrophobic drugs that are normally difficult to formulate and deliver in vivo can be greatly enhanced with nanotechnology. Therapeutics that are incorporated into nanoparticles can also benefit from a lengthened therapeutic window through sustained release, and these platforms can be further assimilated into hydrogel superstructures for additional capabilities [ 383 ].…”

Section: Discussionmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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“…To improve the stability and therapeutic index of NSs, incorporating NSs into hydrogels has recently gained much attention. 16 Hydrogels are hydrophilic 3D cross-linked networks that can preserve the structural integrity and functions of incorporated materials. 17 As advanced drug delivery reservoirs, they also have the characteristics of reduced irritation, decreased adverse effects and sustained release.…”

Section: Introductionmentioning

confidence: 99%

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization

Zou¹,

He²,

Wang³

et al. 2021

IJN

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Purpose Pore-forming toxins (PFTs) perform important functions during bacterial infections. Among various virulence-targeting therapies, nanosponges (NSs) have excellent neutralization effects on multiple PFTs. To enhance treatment efficacy, NSs tend to be incorporated into other biomaterials, such as hydrogels. Methods In the present work, red blood cell (RBC) vesicles were harvested to wrap polymer nanoparticles, leading to the formation of NSs, and the optimal Pluronic F127 hydrogel concentration was determined for gelation. Then, a novel detoxification system was constructed by incorporating NSs into an optimized Pluronic F127 hydrogel (NS-pGel). Next, the system was characterized by rheological and sustained release behavior as well as micromorphology. Then, the in vitro neutralization effect of NS-pGel on various PFTs was examined by a hemolysis protocol. Finally, therapeutic and prophylactic detoxification efficiency was evaluated in a mouse subcutaneous infection model in vivo. Results A thermosensitive, injectable detoxification system was successfully constructed by loading NSs into a 30% Pluronic F127 hydrogel. Characterization results demonstrated that the NS-pGel hybrid system sustained an ideal fluidity and viscosity at lower temperatures but exhibited a quick sol-gel transition capacity near body temperature. In addition, this hybrid system had a sustained release behavior accompanied by good biocompatibility and biodegradability. Finally, the NS-pGel system showed neutralization effects similar to those of NSs both in vitro and in vivo, indicating a good preservation of NS functionality. Conclusion In conclusion, we constructed a novel temperature-sensitive detoxification system with good biocompatibility and biodegradability, which may be applied to the clinical treatment of PFT-induced local lesions and infections.

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“…187 Nanocomposite hydrogels are indispensable for biological applications, catalysis and fabricating semiconducting devices. [188][189][190] Based on the same principle, Fe(III)/Fe(II) redox conversion has been utilized extremely in fabricating dynamic gels. For example, Zhang et al synthesized a redox tunable hydrogel system comprising of poly(acrylic acid) (PAAc), hexadecyl methacrylate and Fe(III)-citrate that evolved under UV-light.…”

Section: (Iii) Uv Light Induced Reactionmentioning

confidence: 99%