Nanoparticle induced fusion of lipid membranes

Blasco, Sofía; Sukeník, Lukáš; Vácha, Robert

doi:10.1039/d4nr00591k

Nanoscale

2024

DOI: 10.1039/d4nr00591k

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Nanoparticle induced fusion of lipid membranes

Sofía Blasco,

Lukáš Sukeník,

Robert Vácha

Abstract: We found that the optimal fusogenic nanoparticle is able to form a stalk but does not overstabilize it, facilitating the opening of a fusion pore.

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Cited by 3 publications

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Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Ma,

Dong,

et al. 2024

Chin J Polym Sci

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Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Ma,

Dong,

et al. 2024

Chin J Polym Sci

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Structural Reorganizations and Nanodomain Emergence in Lipid Membranes Driven by Ionic Liquids

Gupta,

Sharma,

Hitaishi

et al. 2024

Langmuir

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Ionic liquids (ILs) have promising applications in pharmaceuticals and green chemistry, but their use is limited by toxicity concerns, mainly due to their interactions with cell membranes. This study examines the effects of imidazolium-based ILs on the microscopic structure and phase behavior of a model cell membrane composed of zwitterionic dipalmitoylphosphatidylcholine (DPPC) lipids. Small-angle neutron scattering and dynamic light scattering reveal that the shorter-chain IL, 1-hexyl-3-methylimidazolium bromide (HMIM [Br]), induces the aggregation of DPPC unilamellar vesicles. In contrast, this aggregation is absent with the longer alkyl chain IL, 1-decyl-3-methylimidazolium bromide (DMIM [Br]). Instead, DMIM[Br] incorporation leads to the formation of distinct IL-poor and IL-rich nanodomains within the DPPC membrane, as evidenced by X-ray reflectivity, differential scanning calorimetry, and molecular dynamics simulations. The less evident nanodomain formation with HMIM[Br] underscores the role of hydrophobic interactions between lipid alkyl tails and ILs. Our findings demonstrate that longer alkyl chains in ILs significantly enhance their propensity to form membrane nanodomains, which is closely linked to enhanced membrane permeability, as shown by dye leakage measurements. This heightened permeability likely underlies the greater cytotoxicity of longer-chain ILs. This crucial link between nanodomains and toxicity provides valuable insights for designing safer, more environmentally friendly ILs, and promoting their use in biomedical applications and sustainable industrial processes.

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Metaparticles: Computationally engineered nanomaterials with tunable and responsive properties

Paesani,

Ilie

2024

The Journal of Chemical Physics

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In simulations, particles are traditionally treated as rigid platforms with variable sizes, shapes, and interaction parameters. While this representation is applicable for rigid core platforms, particles consisting of soft platforms (e.g., micelles, polymers, elastomers, and lipids) inevitably deform upon application of external stress. We introduce a generic model for flexible particles, which we refer to as MetaParticles (MPs). These particles have tunable properties, can respond to applied tension, and can deform. A MP is represented as a collection of Lennard-Jones beads interconnected by spring-like potentials. We model a series of MPs of variable sizes and symmetries, which we subject to external stress, followed by relaxation upon stress release. The positions and the orientations of the individual beads are propagated by Brownian dynamics. The simulations show that the mechanical properties of the MPs vary with size, bead arrangement, and area of applied stress, and share an elastomer-like response to applied stress. Furthermore, MPs deform following different mechanisms, i.e., small MPs change shape in one step, while larger ones follow a multi-step deformation pathway, with internal rearrangements of the beads. This model is the first step toward the development and understanding of particles with adaptable properties with applications in the biomedical field and in the design of bioinspired metamaterials.

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Nanoparticle induced fusion of lipid membranes

Abstract: We found that the optimal fusogenic nanoparticle is able to form a stalk but does not overstabilize it, facilitating the opening of a fusion pore.

Cited by 3 publications

References 48 publications

Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Structural Reorganizations and Nanodomain Emergence in Lipid Membranes Driven by Ionic Liquids

Metaparticles: Computationally engineered nanomaterials with tunable and responsive properties

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