Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: Novel insights and perspectives

Wang, Haiying; Qiao, Chun‐Feng; Guan, Qiutong; Li, Zhenhua

doi:10.1016/j.ajps.2023.100829

Cited by 18 publications

(7 citation statements)

References 186 publications

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“…Using the desired physicochemical reactions ultimately leads to the apoptosis of tumor tissue [23]. PDT therapy involves the use of a suitable photosensitizer, which accumulates in the decedent-cancerous tissue [24]. Cellular hypoxia is one of the main problems in the transport of drugs, leading to the inactivation of their action [25].…”

Section: Mechanism Of Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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Photodynamic therapy (PDT) has emerged as a promising modality for the treatment of various diseases. This non-invasive approach utilizes photosensitizing agents and light to selectively target and destroy abnormal cells, providing a valuable alternative to traditional treatments. Research studies have explored the application of PDT in different areas of the head. Research is focusing on a growing number of new developments and treatments for cancer. One of these methods is PDT. Photodynamic therapy is now a revolutionary, progressive method of cancer therapy. A very important feature of PDT is that cells cannot become immune to singlet oxygen. With this therapy, patients can avoid lengthy and costly surgeries. PDT therapy is referred to as a safe and highly selective therapy. These studies collectively highlight the potential of PDT as a valuable therapeutic option in treating the head area. As research in this field progresses, PDT may become increasingly integrated into the clinical management of these conditions, offering a balance between effectiveness and minimal invasiveness.

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Section: Mechanism Of Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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“…Ferroptosis therapy represents a powerful modality of non-apoptotic cell death, which can effectively evade chemoresistance in apoptotic pathways. 73,74 The combined treatment of triple-negative breast cancer by CPT-based chemotherapy and ferrocene-based ferroptosis therapy was developed (Table 1-no. 19).…”

Section: Reduction-responsive Cpt Prodrug Nanomedicinesmentioning

confidence: 99%

Camptothecin-based prodrug nanomedicines for cancer therapy

Zhang,

Yu,

Guo

et al. 2023

Nanoscale

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“…Imaging-guided photodynamic therapy (PDT), a highly promising antineoplastic technique, has garnered considerable attention owing to its integrated merits of light-triggered real-time noninvasive diagnosis and simultaneous in situ therapy. − It could serve as a promising alternative to other intervention therapies. Cytotoxic reactive oxygen species (ROS) can be utilized to downstage tumor, while fluorescence with high spatiotemporal resolution and sensitivity can be used for follow-on surgical navigation. , Despite ongoing research efforts, photosensitizers (PSs) that can be applied in this practice are rare. , This may be attributed to the following factors.…”

Section: Introductionmentioning

confidence: 99%

“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers

Yang,

Zhang,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Imaging-guided photodynamic therapy (PDT) holds great potential for tumor therapy. However, achieving the synergistic enhancement of the reactive oxygen species (ROS) generation efficiency and fluorescence emission of photosensitizers (PSs) remains a challenge, resulting in suboptimal image guidance and theranostic efficacy. The hypoxic tumor microenvironment also hinders the efficacy of PDT. Herein, we propose a "two-stage rocketpropelled" photosensitive system for tumor cell ablation. This system utilizes MitoS, a mitochondria-targeted PS, to ablate tumor cells. Importantly, MitoS can react with HClO to generate a more efficient PS, MitoSO, with a significantly improved fluorescence quantum yield. Both MitoS and MitoSO exhibit less O 2 -dependent type I ROS generation capability, inducing apoptosis and ferroptosis. In vivo PDT results confirm that this mitochondrial-specific type I−II cascade phototherapeutic strategy is a potent intervention for tumor downstaging. This study not only sheds light on the correlation between the PS structure and the ROS generation pathway but also proposes a novel and effective strategy for tumor downstaging intervention.

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Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: Novel insights and perspectives

Cited by 18 publications

References 186 publications

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Camptothecin-based prodrug nanomedicines for cancer therapy

“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers

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