Nanoparticle/Polyelectrolyte Complexes for Biomimetic Constructs

Yin, Yixuan; Tan, Lianjiang; Wang, Beibei; Yin, Bangqi; Yang, Yang; Russell, Thomas P.; Shi, Shaowei

doi:10.1002/adfm.202108895

Cited by 23 publications

(24 citation statements)

References 27 publications

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“…Furthermore, from the compositional aspect, PEO and P2VP blocks are biocompatible and have been widely explored for biomedical applications such as drug delivery and cancer therapy. [ 30 , 31 ] Fe is an essential element for human beings and played a key role in metabolic processes. The safety evaluation experiment (Figure S7 , Supporting Information) demonstrated that the viability of 1‐day‐old HeLa cells after 30 min treatment with Fe 3+ 0.06 ‐P2VP, Fe 3+ 0.02 ‐OCPCs, and Fe 3+ 0.06 ‐OCPCs at different Fe 3+ concentrations reached an average of 90%.…”

Section: Resultsmentioning

confidence: 99%

A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale

Wang

et al. 2022

Advanced Science

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Increasingly intricate in their multilevel multiscale microarchitecture, metamaterials with unique physical properties are challenging the inherent constraints of natural materials. Their applicability in the nanomedicine field still suffers because nanomedicine requires a maximum size of tens to hundreds of nanometers; however, this size scale has not been achieved in metamaterials. Therefore, “nano‐metamaterials,” a novel class of metamaterials, are introduced, which are rationally designed materials with multilevel microarchitectures and both characteristic sizes and whole sizes at the nanoscale, investing in themselves remarkably unique and significantly enhanced material properties as compared with conventional nanomaterials. Microarchitectural regulation through conventional thermodynamic strategy is limited since the thermodynamic process relies on the frequency‐dependent effective temperature, Teff(ω), which limits the architectural regulation freedom degree. Here, a novel dual‐kinetic control strategy is designed to fabricate nano‐metamaterials by freezing a high‐free energy state in a Teff(ω)‐constant system, where two independent dynamic processes, non‐solvent induced block copolymer (BCP) self‐assembly and osmotically driven self‐emulsification, are regulated simultaneously. Fe3+‐“onion‐like core@porous corona” (Fe3+‐OCPCs) nanoparticles (the products) have not only architectural complexity, porous corona and an onion‐like core but also compositional complexity, Fe3+ chelating BCP assemblies. Furthermore, by using Fe3+‐OCPCs as a model material, a microstructure‐biological performance relationship is manifested in nano‐metamaterials.

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Section: Resultsmentioning

confidence: 99%

A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale

Wang

et al. 2022

Advanced Science

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“…1) The inherent surface tension between two immiscible phases drives the formation of the confined space of single structure MPRs and the interface coalescence. [ 30 ] Surface tension, also known as free energy cost, acts tangentially to the interface between the immiscible phases and drives the emulsion systems to form a geometry that minimizes the surface area to volume ratio, that is, a sphere. For the same reason, the interface coalescence of MPRs is a thermodynamically favored process.…”

Section: Effects Of Emulsion Templates On the Interface Characteristi...mentioning

confidence: 99%

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Xin

et al. 2022

Adv Materials Inter

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with advanced functions, [6] can be attributed to two aspects. 1) The exquisite control and manipulation abilities of fluids at a microscale have reached a new height as droplet microfluidic technology is leaping forward. The precisely tunable interface characteristics of emulsion templates, determined by the optimization of fluids composition and interfacial complexity, contribute to the inherent interface properties of MPRs. [7][8][9][10] 2) The introduction of advanced materials expands the interface characteristics of the MPRs. Considerable natural polymers, synthetic polymers, and stimuli-responsive biomaterials have been employed continuously with the development of materials science. As a result, a series of performances possessed by the materials can significantly improve the inherent interface characteristics of the MPRs under a combination of the mentioned advanced materials. [11][12][13][14][15][16] Overall, researchers have stressed the improvement of the development process of interface characteristics and functions (such as substance encapsulation and controlled release) by providing novel technical innovations in every aspect to support biomedical clinical applications related to cells and drugs. Recently, the types, preparation methods, and biomedical applications of MPRs have been systematically presented in several excellent reviews. [3][4][5][8][9][10][17][18][19][20] The thermodynamic properties of liquid-liquid droplet reactors have been analyzed more specifically in some reviews. [7,17] However, the origin of interface characteristics of MPRs, as well as the function and cuttingedge cell-and drug-related biomedical applications determined by the interface characteristics, are deficient in a systematic summary. This review highlights that different emulsion templates endow the inherent interface characteristics of MPRs. Besides, the methods of converting emulsion templates into MPRs are summarized by introducing specific functional biomaterials, followed by the flexible and adjustable interface characteristics expanded by the mentioned materials. Moreover, the biomedical applications related to cells and drugs are analyzed based on the mentioned unique interface characteristics of the MPRs. Furthermore, the existing challenges regarding the current status are presented, and the subsequent development of the MPRs is illustrated from various perspectives (Scheme 1).

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“…22−24 Furthermore, diverse multicompartmentalized structures can be formed, allowing selective segregation of cargo within the domains. 24 While these studies demonstrate the tremendous promise of PE/NP membranes formed by interfacial complexation, the membrane growth mechanism in this process remains unknown. Most studies to date in ATPS have focused on the bulk dynamics that occur during the interfacial complexation process and have not delved deeply into the assembly mechanisms that determine membrane growth.…”

Section: Introductionmentioning

confidence: 99%

“…Membranes formed by PE/NP complexation differ in permeability from their PE/PE counterparts, and NP can be selected to impart additional functionalities. For example, PE/NP membranes can exhibit high rigidity and permeability, can exchange materials across the membrane via osmotic fluxes, and can incorporate cargo by exploiting interactions with the charged species. − Furthermore, diverse multicompartmentalized structures can be formed, allowing selective segregation of cargo within the domains …”

Section: Introductionmentioning

confidence: 99%

Ionic Strength-Dependent Assembly of Polyelectrolyte-Nanoparticle Membranes via Interfacial Complexation at a Water–Water Interface

2022

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Complexation between oppositely charged nanoparticles (NPs) and polyelectrolytes (PEs) is a scalable approach to assemble functional, stimuli-responsive membranes. Complexation at interfaces of aqueous two-phase systems (ATPSs) has emerged as a powerful method to assemble these functional structures. Membranes formed at these interfaces can grow continuously to thicknesses approaching several millimeters and display a high degree of tunability via modification of solution properties such as ionic strength. To identify the membrane assembly mechanism, we study interfacial assembly in a prototypical dextran/PEG ATPS, in which silica (SiO2) NPs suspended in the PEG phase undergo interfacial complexation with poly(diallyldimethylammonium chloride) (PDADMAC) supplied in the dextran phase. Using a microfluidic device that facilitates sequential insertion of fluorescent and nonfluorescent PDADMAC, we observe a transition in the membrane growth mechanism with ionic strength. In the absence of added salt ([NaCl] = 0 mM) PDADMAC chains permeate through the existing membrane to complex with NPs on the PEG side of the membrane, leading to the formation of well-stratified structures. At elevated ionic strength ([NaCl] = 500 mM), this permeation mechanism is lost. Rather, the complexing species incorporate uniformly across the membrane. We attribute this transition to a rapid exchange of PE-counterion, NP-counterion, and PE/NP binding sites facilitated by an increase in extrinsically compensated charged groups on the NPs and PEs at high salinity. These PDADMAC/SiO2 NP membranes have tremendous potential for the formation of functional membranes, offering control over the internal structure and serving as an ideal system for the generation of targeted release systems.

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Nanoparticle/Polyelectrolyte Complexes for Biomimetic Constructs

Cited by 23 publications

References 27 publications

A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale

A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Ionic Strength-Dependent Assembly of Polyelectrolyte-Nanoparticle Membranes via Interfacial Complexation at a Water–Water Interface

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