Nanoparticle–Polymer Synergies in Nanocomposite Hydrogels: From Design to Application

Chen, Tao; Hou, Kai; Ren, Qianyi; Chen, Guoyin; Wei, Peiling; Zhu, Meifang

doi:10.1002/marc.201800337

Cited by 99 publications

(55 citation statements)

References 206 publications

(369 reference statements)

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“…Metal nanoparticles can be combined with a polymer to form a polymer or hydrogel nanocomposite [ 132 , 133 ]. This type of scaffold prevents the nanoparticles from aggregating while preserving their properties.…”

Section: Three-dimensional Cell Culture Methodsmentioning

confidence: 99%

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

et al. 2020

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Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and even more when translated to human patients. Innovative models became essential to develop more accurate knowledge. Tissue engineering provides some of those models, but it mostly relies on the use of prefabricated scaffolds on which cells are seeded. The self-assembly protocol has recently produced organ-specific human-derived three-dimensional models without the need for exogenous material. This strategy will help to achieve the 3R principles.

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Section: Three-dimensional Cell Culture Methodsmentioning

confidence: 99%

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

et al. 2020

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“…Crucial to its success has been the development of rheology modifiers, such as Pluronic F-127 [18,32,33] and nanoclay [14,15,34,35] which can modify the rheological properties of hydrogel inks that enable the printing of complex 3D architectures. Crucial to its success has been the development of rheology modifiers, such as Pluronic F-127 [18,32,33] and nanoclay [14,15,34,35] which can modify the rheological properties of hydrogel inks that enable the printing of complex 3D architectures.…”

mentioning

confidence: 99%

3D Printing of Multifunctional Hydrogels

Chen

Zhao

Liu

et al. 2019

Adv Funct Materials

276

192

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3D printing technology has been widely explored for the rapid design and fabrication of hydrogels, as required by complicated soft structures and devices. Here, a new 3D printing method is presented based on the rheology modifier of Carbomer for direct ink writing of various functional hydrogels. Carbomer is shown to be highly efficient in providing ideal rheological behaviors for multifunctional hydrogel inks, including double network hydrogels, magnetic hydrogels, temperature-sensitive hydrogels, and biogels, with a low dosage (at least 0.5% w/v) recorded. Besides the excellent printing performance, mechanical behaviors, and biocompatibility, the 3D printed multifunctional hydrogels enable various soft devices, including loadable webs, soft robots, 4D printed leaves, and hydrogel Petri dishes. Moreover, with its unprecedented capability, the Carbomer-based 3D printing method opens new avenues for bioprinting manufacturing and integrated hydrogel devices.

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“…The majority of methods to achieve anisotropy within hydrogels depend on external magnetic or electrical stimuli, which is not practically scalable for large-scale production [183]. Hence, continuous developments in the area of soft nanocomposites are essential to produce scalable anisotropic structures showing excellent mechanical properties and to produce responsive materials to multiple stimuli for uses in innovative applications in the fields of TERM, biomedicine, actuators, and sensors.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Natural-Based Hydrogels for Tissue Engineering Applications

et al. 2020

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In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.

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Nanoparticle–Polymer Synergies in Nanocomposite Hydrogels: From Design to Application

Cited by 99 publications

References 206 publications

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

3D Printing of Multifunctional Hydrogels

Natural-Based Hydrogels for Tissue Engineering Applications

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