Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

Saei, Amir Ata; Yazdani, Mahdieh; Lohse, Samuel E.; Bakhtiary, Zahra; Serpooshan, Vahid; Ghavami, Mahdi; Asadian, Mahtab; Mashaghi, Samaneh; Dreaden, Erik C.; Mashaghi, Alireza; Mahmoudi, Morteza

doi:10.1021/acs.chemmater.7b01979

Cited by 102 publications

(63 citation statements)

References 194 publications

(326 reference statements)

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“…Their size, shape, surface-coating agent, charge and stability are only a few of the properties by which AgNP can differ [1]. Today, extensive functionalization strategies are available to modify the surface chemistry of a variety of engineered nanoparticles (NP) [26]. Those coatings are used to stabilize NP against aggregation when stable suspensions are required for product functionality or for improved delivery of the product.…”

Section: Introductionmentioning

confidence: 99%

“…For example, AgNP can be coated by citrate or polyvinylpyrrolidine to increase their stability [28], modified with ATP to act as a selective antibiotic [29] or equipped with COOH-and NH 2 -groups to affect their surface charge in terms of their function in imaging and drug delivery [30]. Once released into the environment, the surface functionalization of AgNP significantly determines its physico-chemical fate, its bioavailability and its toxicity [22,26]. Exemplary, Wu et al [31] observed in a nanocosm experiment that polyethylene glycol AgNP had the highest overall toxicity, followed by silica AgNP, and lastly aminated silica-coated AgNP due to there different dissolution rates und thus stability.…”

Section: Introductionmentioning

confidence: 99%

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Impact of silver nanoparticles (AgNP) on soil microbial community depending on functionalization, concentration, exposure time, and soil texture

et al. 2019

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Background: Increasing exposure to engineered inorganic nanoparticles takes actually place in both terrestric and aquatic ecosystems worldwide. Although we already know harmful effects of AgNP on the soil bacterial community, information about the impact of the factors functionalization, concentration, exposure time, and soil texture on the AgNP effect expression are still rare. Hence, in this study, three soils of different grain size were exposed for up to 90 days to bare and functionalized AgNP in concentrations ranging from 0.01 to 1.00 mg/kg soil dry weight. Effects on soil microbial community were quantified by various biological parameters, including 16S rRNA gene, photometric, and fluorescence analyses.Results: Multivariate data analysis revealed significant effects of AgNP exposure for all factors and factor combinations investigated. Analysis of individual factors (silver species, concentration, exposure time, soil texture) in the unifactorial ANOVA explained the largest part of the variance compared to the error variance. In depth analysis of factor combinations revealed even better explanation of variance. For the biological parameters assessed in this study, the matching of soil texture and silver species, and the matching of soil texture and exposure time were the two most relevant factor combinations. The factor AgNP concentration contributed to a lower extent to the effect expression compared to silver species, exposure time and physico-chemical composition of soil. Conclusions:The factors functionalization, concentration, exposure time, and soil texture significantly impacted the effect expression of AgNP on the soil microbial community. Especially long-term exposure scenarios are strongly needed for the reliable environmental impact assessment of AgNP exposure in various soil types. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of silver nanoparticles (AgNP) on soil microbial community depending on functionalization, concentration, exposure time, and soil texture

et al. 2019

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“…The impact of NPs on organisms depends on their intrinsic properties (Fröhlich 2012;Silva et al 2014;Kwok et al 2016;Nasser et al 2016;Saei et al 2017), fate, and transport in the environment (Levard et al 2012;Seitz et al 2015;Metreveli et al 2016). Once present in the environment, the NPs are transformed, having significantly different physicochemical characteristics from fresh ones (Mudunkotuwa et al 2012;Mitrano et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata

Lekamge

Miranda

Trestrail

et al. 2019

Enviro Toxic and Chemistry

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The transformation of coated silver nanoparticles (AgNPs) and their impacts on aquatic organisms require further study. The present study investigated the role of aging on the transformation of differently coated AgNPs and their sublethal effects on the freshwater alga Raphidocelis subcapitata. The stability of AgNPs was evaluated over 32 d, and the results indicated that transformation of AgNPs occurred during the incubation; however, coating‐specific effects were observed. Fresh AgNPs increased reactive oxygen species (ROS) formation, whereas aged AgNPs induced excessive ROS generation compared with their fresh counterparts. Increased ROS levels caused increased lipid peroxidation (LPO) in treatment groups exposed to both fresh and aged NPs, although LPO was comparatively higher in algae exposed to aged AgNPs. The observed increase in catalase (CAT) activity of algal cells was attributed to early stress responses induced by excessive intracellular ROS generation, and CAT levels were higher in the aged NP treatment groups. In conclusion, AgNPs increased ROS levels and LPO in algae and caused the activation of antioxidant enzymes such as CAT. Overall, the results suggest that aging and coating of AgNPs have major impacts on AgNP transformation in media and their effects on algae. Environ Toxicol Chem 2019;38:2371–2382. © 2019 SETAC

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“…One of major challenges in nanoparticle research is to characterize the surface of nanoparticles at the atomic and molecular level . It is the nanoparticle surface that governs microscopic interfacial functions of whole nanoparticles, such as nanoparticle assembly, ion/molecules sensing, intracellular activity, and heterogeneous catalysis . A detailed landscape of the nanoparticle surface is more crucial in the angstrom and nanometer regime where electronic events occur.…”

Section: Introductionmentioning

confidence: 99%

Negative‐Imaging of Citrate Layers on Gold Nanoparticles by Ligand‐Templated Metal Deposition: Revealing Surface Heterogeneity

Park

2018

Part & Part Syst Charact

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Surface heterogeneity of a metal nanoparticle is typically regarded as boundary defects and various crystalline facets. While organic capping ligands of a single type are assumed to be homogeneously distributed on the nanoparticle surface, heterogeneous surface coverage of citrate molecules on individual facets of gold nanoparticles (AuNPs) is revealed. Pt metallic clusters with 2 nm in diameter, epitaxially grown on the surface of AuNPs by chemical reaction and imaged by high‐resolution transmission electron microscopy, are utilized as negative‐imaging probes for densely packed adlayers where the underneath gold surface may not be accessible for Pt deposition. At pH > 5.0, citrate anions form only a loosely packed layer. At pH 4.5, citrates and citric acids form both loosely packed and densely packed layers that appear phase separated, and the densely packed domain as small as 5 nm × 5 nm is likely composed of fully protonated citric acids. IR spectra indicate that citric acid binds to a surface Au adatom through the oxygen atom of the central hydroxyl group, and similarly, citrate anions bind to Au adatoms through the carboxylate oxygen atom. This study also reveals the role of Au adatom in the adsorption of citrate species on the metallic surface of AuNPs.

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Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

Cited by 102 publications

References 194 publications

Impact of silver nanoparticles (AgNP) on soil microbial community depending on functionalization, concentration, exposure time, and soil texture

Impact of silver nanoparticles (AgNP) on soil microbial community depending on functionalization, concentration, exposure time, and soil texture

The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata

Negative‐Imaging of Citrate Layers on Gold Nanoparticles by Ligand‐Templated Metal Deposition: Revealing Surface Heterogeneity

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