2017
DOI: 10.1016/j.lungcan.2017.09.002
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Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer

Abstract: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.

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Cited by 63 publications
(37 citation statements)
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“…a). Targeting moieties used for this purpose include folic acid, peptides, antibodies and carbohydrates (Table ), and can be either conjugated to a nanoparticle or directly to a PS.…”
Section: Targeting the Tumor Microenvironment With Photochemistrymentioning
confidence: 99%
See 2 more Smart Citations
“…a). Targeting moieties used for this purpose include folic acid, peptides, antibodies and carbohydrates (Table ), and can be either conjugated to a nanoparticle or directly to a PS.…”
Section: Targeting the Tumor Microenvironment With Photochemistrymentioning
confidence: 99%
“…Another common targeting moiety that is used to decorate the surface of nanoparticles is folate, which specifically targets folate receptors . The folate receptor is a GPI‐anchored cell surface receptor that is overexpressed in many cancers, making it an attractive receptor for targeted therapies .…”
Section: Targeting the Tumor Microenvironment With Photochemistrymentioning
confidence: 99%
See 1 more Smart Citation
“…Nanoparticlebased PDT is a new therapeutic strategy that relies on nanoparticles as a carrier or PS. 74,80 Another drawback of conventional PDT is the short wavelength of the excitation light, which is mainly located in the ultraviolet or visible region, resulting in limited penetration depth and in easy distribution by various endogenous light chromophores, such as melanin. 3).…”
Section: Recent Advance Of Nanoparticle-based Pdtmentioning
confidence: 99%
“…79 Targeted molecule-modified nanocarriers not only improve the stability and biocompatibility of PS but also deliver PS to the target cells to improve the curative effect and reduce side effects. 74,80 Another drawback of conventional PDT is the short wavelength of the excitation light, which is mainly located in the ultraviolet or visible region, resulting in limited penetration depth and in easy distribution by various endogenous light chromophores, such as melanin. 81 For overcoming the shortcomings of the PS that required a short wavelength excitation light, new PSs, such as NIR fluorescent dyes, have been developed.…”
Section: Recent Advance Of Nanoparticle-based Pdtmentioning
confidence: 99%