The presence of engineered nanoparticles (ENPs) in the environment can have significant damaging effects for both environment and human health. Emergent nanoscience and nanotechnology are projected to revolutionise industrial production, economy and consumer crossing point, as we know them today. However, widespread use of nanotechnologies may invite and be a source of risks. People in many settings (academic, small and large industrial, and the public in industrialized nations) are either developing or using products containing engineered nanoparticles. However, our understanding of the occupational, health and safety aspects of ENMs is still in its formative stage. This review describes briefly, ENPs and their applications, safety and risk assessment upon exposure to engineered nanoparticles, the routes of human exposure, fate of engineered nanoparticles in the environment and make recommendations on future research in risk assessment of nanomaterials.