Nanoparticles-A Thoracic Toxicology Perspective

Duffin, Rodger; Mills, Nicholas L; Donaldson, Ken

doi:10.3349/ymj.2007.48.4.561

Cited by 89 publications

(54 citation statements)

References 106 publications

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“…However, in very small (ultrafine) size ranges, these particles have been linked with significant oxidative stress mediated toxicity (Duffin, Mills & Donaldson, 2007). Some metals, such as zinc oxide, will dissolve in the body (Gilmour et al, 2006;Charrier & Anastasio, 2011).…”

Section: Clinical Studies and Toxicological Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Clinical Studies and Toxicological Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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“…Literature highlights that the uptake of nanoparticles (pathway and rate) strongly depends on cell type (Sohaebuddin et al 2010) and on the nanoparticle physico-chemical features (Musyanovych et al 2011;Chung et al 2007;Hu et al 2007). It is well admitted that these latter may play a role in nanoparticle cytotoxicity (Greish et al 2011;Yu et al 2011;Chung et al 2007), and several parameters to take into consideration to engineer safer nanoparticles were defined by ISO TS/13014 (2012a) ("safer by design" approach): size, shape, surface functionalization, state of agglomeration and agregation, composition, solubility, dispersibility, specific surface area, density of surface groups and surface chemistry (Frohlich 2012;Duffin et al 2007;Albanese et al 2012). This study will focus on nanoparticle surface functionalization.…”

Section: Introductionmentioning

confidence: 99%

Adsorption at cell surface and cellular uptake of silica nanoparticles with different surface chemical functionalizations: impact on cytotoxicity

et al. 2014

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International audienceSilica nanoparticles are particularly interesting for medical applications because of the high inertness and chemical stability of silica material. However, at the nanoscale their innocuousness must be carefully verified before clinical use. The aim of this study was to investigate the in vitro biological toxicity of silica nanoparticles depending on their surface chemical functionalization. To that purpose, three kinds of 50 nm fluorescent silica-based nanoparticles were synthesized: 1) sterically stabilized silica nanoparticles coated with neutral polyethylene glycol (PEG) molecules, 2) positively charged silica nanoparticles coated with amine groups and 3) negatively charged silica nanoparticles coated with carboxylic acid groups. RAW 264.7 murine macrophages were incubated for 20 hours with each kind of nanoparticles. Their cellular uptake and adsorption at the cell membrane were assessed by a fluorimetric assay and cellular responses were evaluated in terms of cytotoxicity, pro-inflammatory factor production and oxidative stress. Results showed that the highly positive charged nanoparticle, were the most adsorbed at cell surface and triggered more cytotoxicity than other nanoparticles types. To conclude, this study clearly demonstrated that silica nanoparticles surface functionalization represents a key parameter in their cellular uptake and biological toxicity

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“…Interestingly, only PM2.5, relative humidity and temperature were significant to both CVD and COPD ER visits ( Table 3). The effect of these three factors on the mechanisms of toxicity for respiratory and cardiovascular disease can be attributed to the oxidative stress leading to inflammation, which generates the physiological processes evolving as respiratory and/or cardiovascular symptoms like narrowing of airways, shortness of breath, wheezing, cough, and the ability of particles to penetrate the lung wall accumulating in the pulmonary interstitium between the lung and the bloodstream [13]- [15]. As for heat's effect on the health outcomes, research shows that hot-humid conditions are more challenging for patients with respiratory and cardiovascular diseases because heat and humidity affects the body's ability to preserve normothermia [16] [17].…”

Section: Methodsmentioning

confidence: 99%

Application of Multivariate Geostatistics in Environmental Epidemiology: Case Study from Houston, Texas

Anderson¹

2016

GEP

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This study represents an example of investigating the associations between the joint exposure to ozone (O3) and particulate matter of sizes less than or equal to 2.5 micrometers in aerodynamic diameter (PM2.5) and cardiovascular disease (CVD) emergency room (ER) visits and chronic obstructive pulmonary disease (COPD) ER visits using multivariate geostatistics in Houston, Texas, from 2004 to 2009. Analyses showed lack of strong pair-wise association among the predictors of O3, PM2.5, wind speed, relative humidity, and temperature. Whereas CVD and COPD ER visits exhibited a strong positive correlation. Both outcomes drastically increased from 2006 possibly due to immigration from neighboring locations. Parametric testing showed that the data differed significantly between the years. Multivariate multiple regression results on the 2009 data showed that PM2.5, relative humidity, and temperature were significant to both CVD and COPD ER visits. Codispersion coefficients were constant which justified the assumption of intrinsic correlation. That is, our predictors had strong influence on the spatial variability of CVD and COPD ER visits. This multivariate geostatistics approach predicted an increase of 34% in CVD ER visits and 24% increase in COPD ER visits, which calls for more attention from policy makers. The use of multivariate geostatistics analyses enabled us to successfully detect the effects of risk factors on both outcomes.

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Nanoparticles-A Thoracic Toxicology Perspective

Cited by 89 publications

References 106 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Adsorption at cell surface and cellular uptake of silica nanoparticles with different surface chemical functionalizations: impact on cytotoxicity

Application of Multivariate Geostatistics in Environmental Epidemiology: Case Study from Houston, Texas

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