Nanoparticles Advancing Cancer Immunotherapy

Chowdhury, Mohammed; Kubra, Khadizatul; Kanwar, Rupinder K.; Kanwar, Jagat R.

doi:10.1016/b978-0-12-815889-0.00013-1

Cited by 6 publications

(5 citation statements)

References 147 publications

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“…Generally, using immunotherapy can be challenging due to auto-immune side effects, variability in tumor responses rate, and financial cost [36]. A solution to enhance the efficacy of immune agents is using nano-based drug delivery systems (DDSs) through direct targeting of the cancer cells, facilitating intracellular penetration, and boosting the immunogenicity of antigens [41]. To date, there are limited studies on the utilization of DDS combined with immunotherapy for the treatment of HNSCC or OSCC.…”

Section: Introductionmentioning

confidence: 99%

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

et al. 2019

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Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.

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Section: Introductionmentioning

confidence: 99%

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

et al. 2019

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“…Although advances have been made in surgery, radiotherapy, and chemotherapy, the prognosis for this diagnosis has not improved considerably over the past 50 years. To enhance the effect of immune agents, extended-release systems can be used to directly target cancer cells, allowing better intracellular penetration and increasing antigen immunity [53][54][55].…”

Section: Physiology Of Oral Cavity Pathologymentioning

confidence: 99%

“…However, when incorporated into the appropriate biomaterials, controlled release forms with local or systemic actions and increased efficacy can be obtained. We will now present the drugs most commonly used in the treatment of various forms of oral cancers and targeted release systems for which clinical trials are being conducted [53,120].…”

Section: Optimization Of Transmucosal Controlled Failure Systems In O...mentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology. Controlled failure systems applicable in oral pathology include the following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral mucoadhesive films, composite wafers, and smart drugs. The novelty elements brought by this paper refer to the possibilities of optimizing the localized drug delivery system in osteoarthritis of the temporomandibular joint, neuropathic pain, oral cancer, periodontitis, and pericoronitis, as well as in maintaining oral health. We would like to mention the possibility of incorporating natural products into the controlled failure systems used in oral pathology, paying special attention to essential oils.

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“…The safe drinking water is a basic demandfor the people of all over the world. A huge percentage of people of the world are deprived from the pure drinking water including Bangladesh (Chowdhury et al, 2014). Ground water is a very valuable natural resource for the economic development and secure provision of potable water supply in both urban and rural environments (Ghezelsofloo and Ardalan, 2012;Wakode et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Ground Water Quality for Drinking Purpose of Jalalabad Cantonment Area in Sylhet City, Bangladesh

Saha

Maukeeb

Saha

et al. 2022

Am. J. Agric. Sci. Eng. Technol.

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Groundwater quality of Jalalabad cantonment area in Sylhet city is deteriorating. The study was conducted for assessing the ground water quality in drinking purpose of Jalalabad cantonment area in Sylhet city. For human survival, water is a vital resource. Total twenty-five water samples were collected from different parts of Jalalabad Cantonment area from deep aquifer-based tube wells. The collected water samples were analyzed for different physicochemical properties like Color, taste, odor, pH, electrical conductivity (EC), total dissolved solids (TDS), calcium, magnesium, sodium, potassium, boron, sulphur, copper, iron, manganese, and zinc concentrations. All the analyzed parameters compared with the standards prescribed by World Health Organization (WHO) and Bureau of Bangladesh Standard (BBS), in order to assess the ground water quality for drinking purpose. For different parameters of drinking water, the correlation matrix was also calculated. Almost all the physicochemical parameters were found within the prescribed permissible limit. Findings show that some of the parameters Cu and Zn were negatively associated with TDS, Ca2+, Mg2+, S contents.

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Nanoparticles Advancing Cancer Immunotherapy

Cited by 6 publications

References 147 publications

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Assessment of Ground Water Quality for Drinking Purpose of Jalalabad Cantonment Area in Sylhet City, Bangladesh

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