Nanoparticles and nanofibers for topical drug delivery

Goyal, Ritu; Macri, Lauren K.; Kaplan, Hilton M.; Kohn, Joachim

doi:10.1016/j.jconrel.2015.10.049

Cited by 454 publications

(247 citation statements)

References 237 publications

(196 reference statements)

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“…However, only a few of these techniques have been translated into clinically used products so far. Hence, further clinical studies are needed [111].…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Pharmacological Targeting of the Epidermal Barrier

Kemény¹,

Nagy²,

Csoma³

et al. 2016

CPD

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The most important function of the skin is to form a barrier between the body and the external environment. The epidermal barrier prevents transepidermal water loss from the skin, but also serves as a barrier to the entry of harmful environmental allergic, toxic or infectious substances. Inherited defects in the genes encoding the components of the epidermal barrier result in the development of rare genetic disorders, whereas polymorphisms in these genes together with environmental factors cause frequent inflammatory skin diseases, such as atopic dermatitis. In this review, components of the skin-barrier function will be reviewed with special emphasis on how the altered epidermal barrier might be repaired. The different strategies to increase the transdermal penetration of drugs is also discussed.3

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“…However, only a few of these techniques have been translated into clinically used products so far. Hence, further clinical studies are needed [111].…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Pharmacological Targeting of the Epidermal Barrier

Kemény¹,

Nagy²,

Csoma³

et al. 2016

CPD

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“…Of major interest for topical drug delivery are polymeric nanoparticles, nanoemulsions, lipid-based nanoparticles and dendrimers. Dendrimers composed of dendritic polyglycerol (dPG) are hyperbranched synthetic macromolecules that exhibit high-water solubility and biocompatibility (Goyal et al, 2016;Witting et al, 2015;Yang et al, 2012). Interestingly, dPG can serve as a macromolecular reagent to fabricate cross-linked hydrophilic three-dimensional polymeric networks referred to as nanogels (Asadian-Birjand et al, 2012aKabanov & Vinogradov, 2009).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

et al. 2017

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(2017) Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes, Nanotoxicology, 11:2, 267-277, DOI: 10.1080/17435390.2017 ABSTRACTNovel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery. ARTICLE HISTORY

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“…Electrospinning is an inexpensive and simple technique to synthesis the nanofibers from various natural and synthetic polymeric solutions [3]. Due to its high surface area-to-volume ratio, several bioactive agents (herbal extracts, genes and various hydrophilic and hydrophobic drugs) have delivered in a sustained manner for various therapeutic applications [1], [3].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Polycaprolactone Nanofibers for the Controlled Release of Chlorogenic Acid

Ranjith¹

2017

IJRASET

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Electrospun nanofibers have gathered more consideration in worldwide to deliver the bioactive agents in a sustained manner for biomedical applications. In this study, chlorogenic acid loaded polycaprolactone nanofibers were fabricated by electrospinning process and the average fiber diameters were analyzed using scanning electron microscopy analysis. Further, Fourier transform infrared spectroscopy results confirmed that the encapsulated chlorogenic acid was not modified chemically during the electrospinning process. In addition, sustained chlorogenic acid release profile was observed for 12 days. These results imply chlorogenic acid loaded polycaprolactone nanofibers have capability to deliver the chlorogenic acid in a sustained manner for various biomedical applications.

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Nanoparticles and nanofibers for topical drug delivery

Cited by 454 publications

References 237 publications

Pharmacological Targeting of the Epidermal Barrier

Pharmacological Targeting of the Epidermal Barrier

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

Preparation and Characterization of Polycaprolactone Nanofibers for the Controlled Release of Chlorogenic Acid

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