Nanoparticles and the control of oral biofilms

Allaker, Robert P.; Yuan, Zhiyu

doi:10.1016/b978-0-12-815886-9.00010-3

Cited by 11 publications

(11 citation statements)

References 123 publications

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“…Strains tested in our study, such as S. aureus and P. aureginosa , have the propensity to form biofilms and then the proper antibiotic treatment is much more difficult [ 80 ]. One approach to controlling the production of these might be nanomaterials with antibacterial capabilities [ 81 , 82 ]. Some scientific reports have shown that nanoparticles have been effectively applied to eliminate preformed biofilms or to stop their formation on the surfaces of medical equipment [ 83 , 84 ].…”

Section: Resultsmentioning

confidence: 99%

Zinc Oxide Nanocomposites—Extracellular Synthesis, Physicochemical Characterization and Antibacterial Potential

et al. 2020

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This research presents, for the first time, the potential of the Lactobacillus paracasei LC20 isolated from sweet whey as a novel, effective and accessible source for post-cultured ZnO nanocomposites synthesis. The obtained nanocomposites were subjected to comprehensive characterization by a broad spectrum of instrumental techniques. Results of spectroscopic and microscopic analysis confirmed the hexagonal crystalline structure of ZnO in the nanometer size. The dispersion stability of the obtained nanocomposites was determined based on the zeta potential (ZP) measurements—the average ZP value was found to be −29.15 ± 1.05 mV in the 7–9 pH range. The ZnO nanocomposites (NCs) demonstrated thermal stability up to 130 °C based on the results of thermogravimetric TGA/DTG) analysis. The organic deposit on the nanoparticle surface was recorded by spectroscopic analysis in the infrared range (FT-IR). Results of the spectrometric study exhibited nanostructure-assisted laser desorption/ionization effects and also pointed out the presence of organic deposits and, what is more, allowed us to identify the specific amino acids and peptides present on the ZnO NCs surfaces. In this context, mass spectrometry (MS) data confirmed the nano-ZnO formation mechanism. Moreover, fluorescence data showed an increase in fluorescence signal in the presence of nanocomposites designed for potential use as, e.g., biosensors. Despite ZnO NCs’ luminescent properties, they can also act as promising antiseptic agents against clinically relevant pathogens. Therefore, a pilot study on the antibacterial activity of biologically synthesized ZnO NCs was carried out against four strains (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa) by using MIC (minimal inhibitory concentration). Additionally, the colony forming units (CFU) assay was performed and quantified for all bacterial cells as the percentage of viable cells in comparison to a control sample (untreated culture) The nanocomposites were effective among three pathogens with MIC values in the range of 86.25–172.5 μg/mL and showed potential as a new type of, e.g., medical path or ointment formulation.

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Section: Resultsmentioning

confidence: 99%

Zinc Oxide Nanocomposites—Extracellular Synthesis, Physicochemical Characterization and Antibacterial Potential

et al. 2020

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“…At this size range, these nanoparticles possess unique features compared with their bulkier counterparts – they can offer a high surface area, increased reactivity, reduction in thermal resistivity, intracellular delivery of therapeutics depending on the particle shape, size, surface area and charge, and release of high levels of ions at low incorporated amounts, distinguishing them from their bulkier size and micro-sized materials [16] , [321] , [322] . Indeed, an inverse relationship has been demonstrated between the size of the metallic nanoparticles and their antimicrobial activity; particles in the size range of 1–10 nm have the greatest biocidal activity against bacteria [323] , [324] , with silver nanoparticles, ranging from 5 − 40 nm being able to inactivate most microorganisms, including HIV-1 [325] . Thus, due to their antimicrobial ability, nanoparticles made of silver, copper, titanium oxide, and zinc oxide have been incorporated into polymer matrices as filler particles to control biofilm growth [16] .…”

Section: Current and Novel Techniques For Modulating Oral Biofilm Dysmentioning

confidence: 99%

“…For more details on the recent use of nanoparticles in dentistry, please refer to Jiao et al . [16] and Allaker &Yuan [325] .…”

Section: Current and Novel Techniques For Modulating Oral Biofilm Dysmentioning

confidence: 99%

The oralome and its dysbiosis: New insights into oral microbiome-host interactions

Radaic

Kapila

2021

Computational and Structural Biotechnology Journal

266

202

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“…Dental caries are caused by the degradation of tooth apatite caused by the acidic milieu of dental biofilms (i.e., plaque). 85 Yin et al found that dental metals, dental resins, prostheses, and dental coatings include NMs, which prevent implants from developing biofilms and help maintain lengthy oral hygiene. 86 Oral biofilm therapy has also been investigated in NM, which causes the production of ROS and in turn EPS matrix destruction.…”

Section: -Oral Therapymentioning

confidence: 99%

Combating Antibiotic Resistance in Bacteria: The Development of Novel Therapeutic Strategies

Alqahtani¹,

Almustafa²,

Alshehri³

et al. 2022

J. Pure Appl. Microbiol.

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Antibiotic resistance is a major risk to human health worldwide due to antibiotic- and multidrug-resistant bacteria, especially in the case of serious infections, which limits the availability of antimicrobial treatment options. Focusing on the bacterial resistance mechanisms against antibiotics and the conventional strategies used to combat antimicrobial resistance, this review highlights the history of antibiotics and their target mechanisms, mentions the strategy limitations, provides the most recent novel alternative therapies to combat resistance, and illustrates their mode of action and applications that may treat several infectious diseases caused by bacterial resistance. Finally, this paper mentions future prospects that we believe would make a considerable difference in the microbial resistance battle. Novel antibiotic alternative therapies, including nanomaterial therapy, antimicrobial photodynamic therapy, hybrid antimicrobial therapy, and phage therapy, are covered in this review.

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Nanoparticles and the control of oral biofilms

Cited by 11 publications

References 123 publications

Zinc Oxide Nanocomposites—Extracellular Synthesis, Physicochemical Characterization and Antibacterial Potential

Zinc Oxide Nanocomposites—Extracellular Synthesis, Physicochemical Characterization and Antibacterial Potential

The oralome and its dysbiosis: New insights into oral microbiome-host interactions

Combating Antibiotic Resistance in Bacteria: The Development of Novel Therapeutic Strategies

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