Nanoparticles as carriers for drug delivery in cancer

Dadwal, Ankita; Baldi, Ashish; Narang, Raj Kumar

doi:10.1080/21691401.2018.1457039

Cited by 250 publications

(135 citation statements)

References 55 publications

(77 reference statements)

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“…Over the last few decades, nanotechnology has been increasingly used in medicine, including applications for diagnosis, treatment, and tumor targeting in a safer and more effective manner. Nanoparticle (NP)-based drug delivery systems have shown many advantages in cancer treatment, such as good pharmacokinetics, precise targeting of tumor cells, reduction of side effects, and drug resistance (Dadwal et al, 2018;Palazzolo et al, 2018). NPs used in drug delivery systems are usually designed or chosen based on their size and characteristics according to the pathophysiology of the tumors.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

806

346

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Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. Compared to conventional drugs, nanoparticle-based drug delivery has specific advantages, such as improved stability and biocompatibility, enhanced permeability and retention effect, and precise targeting. The application and development of hybrid nanoparticles, which incorporates the combined properties of different nanoparticles, has led this type of drug-carrier system to the next level. In addition, nanoparticle-based drug delivery systems have been shown to play a role in overcoming cancer-related drug resistance. The mechanisms of cancer drug resistance include overexpression of drug efflux transporters, defective apoptotic pathways, and hypoxic environment. Nanoparticles targeting these mechanisms can lead to an improvement in the reversal of multidrug resistance. Furthermore, as more tumor drug resistance mechanisms are revealed, nanoparticles are increasingly being developed to target these mechanisms. Moreover, scientists have recently started to investigate the role of nanoparticles in immunotherapy, which plays a more important role in cancer treatment. In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

806

346

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“…They are biodegradable, nano to submicronic colloidal systems with a diameters range between 3 and 200 nm, able to effectively carry the anti-cancer agents to the tumor site, 30,34,38 attaining a high local drug concentration by site-specific targeting, enhanced permeability, and greater retention. 27,[39][40][41][42][43][44] Thus, the use of nanocarriers can reduce the unwanted systemic side effects and drug resistance. 27,45 However, nanoparticles for colon-targeted oral drug delivery systems have to overcome pH-sensitivity and transit time in the stomach.…”

Section: Introductionmentioning

confidence: 99%

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Wathoni

Nguyen

Rusdin

et al. 2020

DDDT

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Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration.

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“…Nanoparticles are spherical particles with solid cores in the nanoscale size and have been extensively used for drug delivery over the past decades (de Titta et al, 2013;Tran et al, 2017;Ankita et al, 2019). Apart from their spherical shape, most of their parameters and characteristics can be tuned, such as their charges, hydrophobicity or surface properties (i.e., by conjugation of specific moieties), to give a few examples (van der Vlies et al, 2010).…”

Section: Solid Core Nanoparticles (Nps)mentioning

confidence: 99%

Engineering Targeting Materials for Therapeutic Cancer Vaccines

Briquez

Hauert

Titta³

et al. 2020

Front. Bioeng. Biotechnol.

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Therapeutic cancer vaccines constitute a valuable tool to educate the immune system to fight tumors and prevent cancer relapse. Nevertheless, the number of cancer vaccines in the clinic remains very limited to date, highlighting the need for further technology development. Recently, cancer vaccines have been improved by the use of materials, which can strongly enhance their intrinsic properties and biodistribution profile. Moreover, vaccine efficacy and safety can be substantially modulated through selection of the site at which they are delivered, which fosters the engineering of materials capable of targeting cancer vaccines to specific relevant sites, such as within the tumor or within lymphoid organs, to further optimize their immunotherapeutic effects. In this review, we aim to give the reader an overview of principles and current strategies to engineer therapeutic cancer vaccines, with a particular focus on the use of sitespecific targeting materials. We will first recall the goal of therapeutic cancer vaccination and the type of immune responses sought upon vaccination, before detailing key components of cancer vaccines. We will then present how materials can be engineered to enhance the vaccine's pharmacokinetic and pharmacodynamic properties. Finally, we will discuss the rationale for site-specific targeting of cancer vaccines and provide examples of current targeting technologies.

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Nanoparticles as carriers for drug delivery in cancer

Cited by 250 publications

References 55 publications

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Engineering Targeting Materials for Therapeutic Cancer Vaccines

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