Nanoparticles as Contrast Agents for Optoacoustic Imaging

Liopo, Anton V.; Oraevsky, Alexander A.

doi:10.1002/9781118873151.ch5

Cited by 11 publications

(11 citation statements)

References 184 publications

(218 reference statements)

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“…All nanoparticle based optoacoustic CA can be divided in two groups: nanoparticles based on exogenous or endogenous chromophores. While CA development in the previous decade was focused on exogenous nanoparticles, recently the deserved attention is gradually shifting towards less toxic nanoparticles based on endogenous molecules [12] . Two of the biggest advantages of using endogenous contrast agents for imaging applications are safety and the possibility of revealing the true physiological conditions, because the physiological parameters are not altered during optoacoustic image acquisition.…”

Section: Introductionmentioning

confidence: 99%

Melanin nanoparticles as a novel contrast agent for optoacoustic tomography

Liopo

Oraevsky

2015

Photoacoustics

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We describe the synthesis and characterization of melanin-like nanoparticles (MNP) as novel contrast agents for optoacoustic tomography. Good dispersion stability of high concentration MNPs in different biological media was achieved with thiol-terminated methoxy-poly(ethylene glycol), which can be used for further functional conjugation. MNP-PEG were found biocompatible with human MCF-7 and 3T3 cells. Cell toxicity of MNPs was found lower than that of gold nanorods for concentrations that provide equal optical absorbance. Optoacoustic tomography images were obtained with Laser Optoacoustic Imaging System (LOIS-3D) from tubes filled with contrast agents and live mice. Imaging of tubes permitted verification of the system resolution <300 μm and sensitivity Δμa=0.03/cm under safe laser fluence of 20 mJ/cm2. Water suspensions of MNP demonstrated optoacoustic efficiency that is about equal to that of gold nanorods under conditions of equal optical absorption. We conclude that MNPs have the potential for biomedical imaging applications as optoacoustic contrast agents.

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Section: Introductionmentioning

confidence: 99%

Melanin nanoparticles as a novel contrast agent for optoacoustic tomography

Liopo

Oraevsky

2015

Photoacoustics

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“…1 The combination of their nanometre size and their unique physiochemical features enable nanomaterials to operate at the biomolecular level, lending them to a wide variety of applications for biomedical and biotechnological applications such as photothermal therapy, 2 optoacoustic imaging 3 as well as colorimetric and thermal biosensors. 4 The properties of gold and magnetic nanoparticles (NPs) lend themselves particularly well to applications relating to diagnosis, drug delivery, imaging, treatment and theranostics.…”

Section: Introductionmentioning

confidence: 99%

In vitro cell cytotoxicity profile and morphological response to polyoxometalate-stabilised gold nanoparticles

et al. 2016

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The size and redox properties of molecular polyoxometalates (POMs) make them extremely relevant for bioapplications: from disrupting tumour growth and enzyme inhibition, to DNA-intercalating agents and antimicrobial applications. Their unique ability to reversibly dominate and receive electrons, coupled with their high anionic charge, also makes them suitable for the preparation of zero-valent state metal nanoparticles (NPs) from molecular precursors. Polyoxometalate-stabilised nanoparticles (NPs@POM) are therefore an ideal delivery vehicle for bioactive POMs. Here we show how POM-stabilised gold NPs (AuNPs@POM) are massively internalised into Vero (kidney epithelial) and B16 (skin melanoma) cell lines with variable cytotoxic effects. Cell viability assays and quantification of cytoplasmic membrane composition revealed that the Vero cell line was unaltered by the internalisation of these hybrid particles; while their internalisation in B16 tumour cells produced mild cytotoxic effects and an antiproliferative cell cycle arrest in the G0/G1 and G2/M phases. The observed perturbation of the tumour cell line combined with the high degree of internalisation means that these (or similar) NPs@POM could serve as candidates for a range of bioapplications in diagnostics or therapy.

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“…There is a great interest in the biomedical community in the development of diagnostic contrast agents for optoacoustic imaging based on nanoparticles. These works have been recently reviewed [110]. Here, we give just one example of molecular optoacoustic imaging performed at TomoWave Laboratories.…”

Section: Molecular Optoacoustic Imagingmentioning

confidence: 97%

Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

2014

Biomedical Photonics Handbook

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Nanoparticles as Contrast Agents for Optoacoustic Imaging

Cited by 11 publications

References 184 publications

Melanin nanoparticles as a novel contrast agent for optoacoustic tomography

Melanin nanoparticles as a novel contrast agent for optoacoustic tomography

In vitro cell cytotoxicity profile and morphological response to polyoxometalate-stabilised gold nanoparticles

Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

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