Nanoparticles as Novel Emerging Therapeutic Antibacterial Agents in the Antibiotics Resistant Era

Fatima, Faria; Siddiqui, Saba; Khan, Waqar Ahmad

doi:10.1007/s12011-020-02394-3

Cited by 75 publications

(43 citation statements)

References 121 publications

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“…Metal NPs mainly act through generation of reactive oxygen species that disrupt a wide range of metabolic processes including disruption of the membrane, inhibition of cytochromes, destabilization of ribosomes and DNA damage (Lee et al, 2019). Metal NPs prevent growth of such pathogens as Salmonella typhi, S. aureus (including MRSA), E. coli, P. aeruginosa, S. enterica, and K. pneumoniae (Fatima et al, 2020).…”

Section: Nanoparticlesmentioning

confidence: 99%

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

2021

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Rising antibiotic resistance is a global threat that is projected to cause more deaths than all cancers combined by 2050. In this review, we set to summarize the current state of antibiotic resistance, and to give an overview of the emerging technologies aimed to escape the pre-antibiotic era recurrence. We conducted a comprehensive literature survey of >150 original research and review articles indexed in the Web of Science using “antimicrobial resistance,” “diagnostics,” “therapeutics,” “disinfection,” “nosocomial infections,” “ESKAPE pathogens” as key words. We discuss the impact of nosocomial infections on the spread of multi-drug resistant bacteria, give an overview over existing and developing strategies for faster diagnostics of infectious diseases, review current and novel approaches in therapy of infectious diseases, and finally discuss strategies for hospital disinfection to prevent MDR bacteria spread.

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Section: Nanoparticlesmentioning

confidence: 99%

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

2021

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“…The unique properties of nanoparticles (NPs) have significantly altered the design and functions of the therapeutic agents, improved the efficacy of targeted drug delivery systems, and alleviated the unintended side effects of the anticancer drugs. [5][6][7] Furthermore, the 'nano-medicine' facilitates simultaneous injection of two or more drugs in combination, continuous monitoring of targeted drug delivery pathway through multidimensional imaging systems, and better delivery of water-insoluble drugs. [8] Zinc oxide is one of the prominent nanoparticles possessing versatile properties such as antimicrobial, antifouling, cytotoxic, photocatalytic, biosensing, antiapoptotic, UV ray's protector.…”

Section: Introductionmentioning

confidence: 99%

“…The introduction of nanotechnology in medicine has dramatically improved the diagnosis and treatment of various illnesses, including tumors and cancer. The unique properties of nanoparticles (NPs) have significantly altered the design and functions of the therapeutic agents, improved the efficacy of targeted drug delivery systems, and alleviated the unintended side effects of the anticancer drugs [5–7] . Furthermore, the ′nano‐medicine′ facilitates simultaneous injection of two or more drugs in combination, continuous monitoring of targeted drug delivery pathway through multidimensional imaging systems, and better delivery of water‐insoluble drugs [8]…”

Section: Introductionmentioning

confidence: 99%

Seaweed Mediated Fabrication of Zinc Oxide Nanoparticles and their Antibacterial, Antifungal and Anticancer Applications

Anjali

Sangeetha²,

Raghunathan³

et al. 2021

ChemistrySelect

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Synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous extracts of seaweeds, Ulva lactuca, and Stoechospermum marginatum and their antibacterial, antifungal and anticancer activity have been reported. The UV absorption peaks at 310 nm and 345 nm confirmed the formation of ZnO NPs using U.lactuca (Ul-ZnO) and S.marginatum (Sm-ZnO), respectively. The XRD patterns indicated the crystalline nature of ZnO NPs with hexagonal wurtzite structure. The transmission electron microscopic analysis revealed that the ZnO NPs contain spherical and round-shaped particles with a size range of 12-17 nm for Ul-ZnO and 6-11 nm for Sm-ZnO NPs. The antibacterial activity and antifungal activity of both the NPs (Sm-ZnO and Ul-ZnO) were comparable. The results of the cytotoxicity assay of Ul-ZnO and Sm-ZnO NPs revealed that Ul-ZnO NPs recorded the maximum mortality rate of 97.34 % with an IC 50 value of 91.18 μg/ml.

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“…[ 4 ]. In a search for new, cheap, and simple solutions of these problems, a significant effort has been devoted to the development of antibacterial agents based on nanoparticles [ 5 , 6 , 7 ]. In contrast to conventional antibiotics, such materials possess a range of unique physicochemical and biological properties, e.g., high surface-to-volume ratio that increases contact area with microorganisms, high stability, possibility of easy modification with various functional groups, ligands, targeting agents and other biomolecules, enabling not only disinfection, but also its monitoring and targeting [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization

et al. 2021

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Uniformly sized magnetite nanoparticles (Dn = 16 nm) were prepared by a thermal decomposition of Fe(III) oleate in octadec-1-ene and stabilized by oleic acid. The particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups available for the attachment to the iron oxide and at the same time enabling (co)polymerization of 2-(dimethylamino)ethyl methacrylate and/or 2-tert-butylaminoethyl methacrylate at two molar ratios. The poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and poly[2-(dimethylamino)ethyl methacrylate-co-2-tert-butylaminoethyl methacrylate] [P(DMAEMA-TBAEMA)] polymers and the particles were characterized by 1H NMR spectroscopy, size-exclusion chromatography, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, magnetometry, and ATR FTIR and atomic absorption spectroscopy. The antimicrobial effect of cationic polymer-coated magnetite nanoparticles tested on both Escherichia coli and Staphylococcus aureus bacteria was found to be time- and dose-responsive. The P(DMAEMA-TBAEMA)-coated magnetite particles possessed superior biocidal properties compared to those of P(DMAEMA)-coated one.

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Nanoparticles as Novel Emerging Therapeutic Antibacterial Agents in the Antibiotics Resistant Era

Cited by 75 publications

References 121 publications

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Seaweed Mediated Fabrication of Zinc Oxide Nanoparticles and their Antibacterial, Antifungal and Anticancer Applications

Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization

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