Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade

Melim, Catarina; Magalhães, Mariana; Paiva‐Santos, Ana Cláudia; Campos, Elisa J.; Cabral, Célia

doi:10.1080/17425247.2022.2041599

Cited by 23 publications

(12 citation statements)

References 192 publications

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“…Therefore, phytochemicals are suitable for nanomedicine, specifically for conjugating with various NPs or for encapsulation into nanocarriers. These nanophyto-formulations demonstrate various potential health benefits in infectious, cardiovascular, and neurodegenerative diseases as well as cancer ( Nazer et al, 2020 ; Hesari et al, 2021 ; Bhattacharya et al, 2022 ; Melim et al, 2022 ).…”

Section: Tumor Cells Targeting By Nanoparticlesmentioning

confidence: 99%

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

et al. 2023

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Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting affected individuals against associated multidrug resistance and disease progression. Nanotherapeutic agents have the potential to go beyond state-of-the-art approaches in overall cancer management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs have already been approved by the US Food and Drug Administration (FDA) for treating different cancer types. Phytochemicals isolated from plants demonstrate considerable potential for nanomedical applications in oncology thanks to their antioxidant, anti-inflammatory, anti-proliferative, and other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake of therapeutic agents, and mitigate the side effects of toxic anticancer treatments. Per evidence, phytochemical-based NPs can specifically target CSCs decreasing risks of tumor relapse and metastatic disease manifestation. Therefore, this review focuses on current outlook of phytochemical-based NPs and their potential targeting CSCs in cancer research studies and their consideration in the framework of predictive, preventive, and personalized medicine (3PM).

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Section: Tumor Cells Targeting By Nanoparticlesmentioning

confidence: 99%

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

et al. 2023

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“…Lack of nano pharmaceutical approaches to incorporate these SLs into nanocarriers in target organs to increase their bioavailability and effectiveness. Nanotechnologies in cancer aim to develop a new delivery system for bioactive compounds with the following goals:the supply of phytochemicals at a rate directly correlated with the body's needs, during chemotherapy and the transport of phytochemicals to the targeted tumors [158][159][160]. v. Insufficient in vivo studies and the lack of translational studies with the mentioned compounds to establish effective doses in humans.…”

Section: Limitations and Clinical Gapsmentioning

confidence: 99%

Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies

Dhyani

Sati²,

Sharma³

et al. 2022

Cancer Cell Int

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Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer prevention, as they have proven efficacy and fewer side effects. In today's scenario, when cancer cases rapidly increase in developed and developing countries, the anti-cancerous plant-based compounds become highly imperative. Among others, the Asteraceae (Compositae) family's plants are rich in sesquiterpenoid lactones, a subclass of terpenoids with wide structural diversity, and offer unique anti-cancerous effects. These plants are utilized in folk medicine against numerous diseases worldwide. However, these plants are now a part of the modern medical system, with their sesquiterpenoid lactones researched extensively to find more effective and efficient cancer drug regimens. Given the evolving importance of sesquiterpenoid lactones for cancer research, this review comprehensively covers different domains in a spectrum of sesquiterpenoid lactones viz (i) Guaianolides (ii) Pseudoguaianolide (iii) Eudesmanolide (iv) Melampodinin A and (v) Germacrene, from important plants such as Cynara scolymus (globe artichoke), Arnica montana (wolf weeds), Spilanthes acmella, Taraxacum officinale, Melampodium, Solidago spp. The review, therefore, envisages being a helpful resource for the growth of plant-based anti-cancerous drug development.

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“…These cancer-suppressing phytochemicals act mainly by affecting the signaling molecules that have either been abnormally activated or silenced. These signaling molecules, which are usually kinases, are responsible for activating genes that regulate cell growth, differentiation, and apoptosis ( Melim et al, 2022 ). In order to minimize the chemotherapeutic induced drug toxicities and associated drug resistance in lung cancers, the use of nutraceuticals such as silibinin has taken precedence in recent times.…”

Section: Introductionmentioning

confidence: 99%

“…In terms of pharmacokinetics, only 23%–47% of orally administered silibinin is absorbed from the gastrointestinal tract and is metabolized by cytochrome class of enzymes ( Jančová et al, 2007 ; Ahmad et al, 2021 ). Conjugation of phytochemical molecules with nanoparticles helps in overcoming the above challenges along with distinct advantages such as desired penetration, controlled release, optimal distribution and specificity ( Ghosh et al, 2021b ; Srivastava et al, 2021 ; Melim et al, 2022 ; Nikdouz et al, 2022 ). Several nanoplatforms such as those based on glycyrrhizic acid, PVP PEG, PLGA, chitosan, carbon nanotubes, lipid, and magnetic nanoparticles have been explored for conjugation with silibinin ( Takke & Shende, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Use of gold nanoparticle-silibinin conjugates: A novel approach against lung cancer cells

Ravi

Zeyaullah²,

Ghosh³

et al. 2022

Front. Chem.

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Lung cancer presents one of the most challenging carcinomas with meager 5-year survival rates (less than 20%), high metastasis and high recurrence due to chemo- and radio- resistance. An alternative or complementation to existing prognosis modalities is the use of phytochemicals such as silibinin, which targets essential cytokines, angiogenic factors and transcription factors for a profound anti-tumor effect. However, the problems of low solubility in an aqueous physiological environment, poor penetration, high metabolism and rapid systemic clearance limit the therapeutic use of silibinin. Conjugation of gold nanoparticles (GNPs) with silibinin may overcome the above challenges along with distinct advantages of biocompatibility, optical properties for monitoring and causation of cytotoxicity in cancer cells. The current study thus aims to develop silibinin conjugated gold nanoparticles (Sb-GNPs) with pH responsive release in the cancer microenvironment, optimizing several parameters for its higher activity and further evaluate the nanoplatform for their efficacy in inducing cell death in vitro against A549 lung cancer cells. GNPs was synthesized using trisodium citrate dihydrate as the reducing agent and further used for the conjugation of silibinin. The synthesized GNPs were found to be monodispersed and spherical in shape. The silibinin was successfully conjugated with gold nanoparticles and long-term stability of GNPs and Sb-GNPs nanoconjugates in suspension phase was confirmed by FTIR and DLS. Anticancer properties of Sb-GNPs were confirmed by different assay using MTT, Trypan blue dye exclusion assay and cell cycle analysis assay. After conjugation of silibinin with GNPs, the efficacy of silibinin increased 4–5 times in killing the cancer cells. This is the first report on using silibinin gold nanoconjugate system for lung cancer therapy with promising future applications.

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Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade

Cited by 23 publications

References 192 publications

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies

Use of gold nanoparticle-silibinin conjugates: A novel approach against lung cancer cells

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