Nanoparticles-assisted Wound Healing: A Review

Abstract

Poor wound treatment impacts millions of humans worldwide, increasing deaths and costs. Wounds have three key complications: (a) a lack of an adequate environment for cell migration, proliferation, and angiogenesis; (b) microbial infection; and (c) unstable and prolonged inflammation.Regrettably, contemporary therapeutic treatments have not entirely tackled these basic difficulties and thus have insufficient medical accomplishment. The incorporation of the extraordinary capabilities of nanomaterials in wound healing has achieved major successes over the years. Nanomaterials can promote a variety of cellular and molecular processes that assist in the wound microenvironment through antibacterial, anti-inflammatory, and angiogenic activities, potentially shifting the surroundings from nonhealing to healing. The current review focuses on novel techniques, with a particular focus on recent revolutionary wound healing and infection control tactics based on nanomaterials, such as nanoparticles, nanocomposites, and scaffolds, which are discussed in depth. Furthermore, the effectiveness of nanoparticles as carriers for therapeutic compounds in woundhealing applications has been investigated which provide researchers an up-to-date sources on the use of nanomaterials and their creative ways that can improve wound-healing uses.

Oxalis pes-caprae L. Extract Conferred Its Biological Activities to Silver Nanoparticles

“…They have also been used to improve the lump-slaying properties of already existing anticancer medications [17]. They also have applications in textile, wound dressing, and device wrapping [22,23]. The large volume-to-surface area is their most sought-after property [24].…”

Harnessing Desert Flora: Biogenic Silver Nanoparticles from Desert Plants Combat Bacterial Infections and Biofilm Formation

“…AgNPs possess various properties, such as antibacterial, antifungal, antiviral, antioxidant, and anticancer. They also act as excellent catalysts in degrading dyes, treating diabetes-related complications, and wound healing [14][15][16][17]. Recently, AgNPs have been used to improve the efficiency of antibiotics by damaging the microbial DNA [18].…”