Nanoparticles Derived from Plant Proteins for cOntrolled Release and Targeted Delivery of Therapeutics

Xu, Helan; Yang, Yiqi

doi:10.2217/nnm.15.84

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…Proteins derived from animals such as β-lactoglobulin, bovine serum albumin, and whey protein isolate, have been used to fabricate nanoparticles. Compared with animal proteins, plant proteins have more hydrophobic amino acids . Under certain conditions, the nanoparticles could be formed by hydrophobic self-assembly .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Pea Protein Isolate Nanoparticles with Various Sizes: Explore the Formation Mechanism

Xie

Liu

et al. 2021

J. Agric. Food Chem.

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Pea protein isolate nanoparticles (PPINs) were successfully prepared by potassium metabisulfite (K 2 S 2 O 5 ). The disulfide bonds were disrupted by K 2 S 2 O 5 , and then the PPINs were formed through self-assembly. The average diameter of PPINs increased from 124.7 to 297.5 nm as the concentration of K 2 S 2 O 5 was increased from 2 to 8 mM, and the PPINs showed higher ζpotentials (−32.2 to −35.8 mV) and unimodal distribution. The content of free sulfhydryl groups first increased and then decreased with the fracture and reformation of disulfide bonds. Subsequently, the increase of the β-sheet, which has considerable hydrophobicity, promoted the formation of PPINs. The formation mechanism of PPINs was explored by dissociation tests: hydrophobic interactions maintained the basic skeleton of PPINs, disulfide bonds stabilized the internal structure, and hydrogen bonds existed on the exterior of the particles. This study provided a simple and economical method to fabricate nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Pea Protein Isolate Nanoparticles with Various Sizes: Explore the Formation Mechanism

Xie

Liu

et al. 2021

J. Agric. Food Chem.

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“…Various sources of proteins have been prepared into nanoparticles, including common plant proteins, such as zein, gluten, and soy protein, and some animal proteins, such as casein, collagen, and albumin. Plant proteins exhibit better loading and protection of actives and superior hydrophobicity and stability compared to traditional animal proteins [ 110 ]. Exploring newer sources of plant proteins, such as some of the less common oilseed proteins, may be a unique source of nanoparticles.…”

Section: Construction Of Protein Nanoparticle Carriersmentioning

confidence: 99%

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Han

Liu

et al. 2023

Foods

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Bioactive substances exhibit various physiological activities—such as antimicrobial, antioxidant, and anticancer activities—and have great potential for application in food, pharmaceuticals, and nutraceuticals. However, the low solubility, chemical instability, and low bioavailability of bioactive substances limit their application in the food industry. Using nanotechnology to prepare protein nanoparticles to encapsulate and deliver active substances is a promising approach due to the abundance, biocompatibility, and biodegradability of proteins. Common protein-based nanocarriers include nano-emulsions, nano-gels, nanoparticles, and nano complexes. In this review, we give an overview of protein-based nanoparticle fabrication methods, highlighting their pros and cons. Additionally, we discuss the applications and current issues regarding the utilization of protein-based nanoparticles in the food industry. Finally, we provide perspectives on future development directions, with a focus on classifying bioactive substances and their functional properties.

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“…Plant protein has become a potential candidate for bioactive material delivery because of its high load and excellent protective effect. Compared with traditional animal proteins, plant proteins have better hydrophobicity and water stability, are more stable in the water environment without diplomatic links, have a higher load capacity for hydrophobic bioactive substances, and have a longer-lasting payload release [ 49 ]. Furthermore, the use of plant proteins can reduce the risk of transmitting zoonotic diseases [ 50 ].…”

Section: Application Of Different Types Of Plant Protein-based Nano-e...mentioning

confidence: 99%

Preparation, Characteristics, and Advantages of Plant Protein-Based Bioactive Molecule Delivery Systems

Guan

Zhang

et al. 2022

Foods

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As a renewable resource, the market trend of plant protein has increased significantly in recent years. Compared with animal protein, plant protein production has strong sustainability factors and a lower environmental impact. Many bioactive substances have poor stability, and poor absorption effects limit their application in food. Plant protein-based carriers could improve the water solubility, stability, and bioavailability of bioactive substances by different types of delivery systems. In this review, we present a detailed and concise summary of the effects and advantages of various plant protein-based carriers in the encapsulation, protection, and delivery of bioactive substances. Furthermore, the research progress of food-grade bioactive ingredient delivery systems based on plant protein preparation in recent years is summarized, and some current challenges and future research priorities are highlighted. There are some key findings and conclusions: (i) plant proteins have numerous functions: as carriers for transportation systems, a shell or core of a system, or food ingredients; (ii) plant protein-based carriers could improve the water solubility, stability, and bioavailability of bioactive substances by different types of delivery systems; and (iii) plant protein-based carriers stabilize bioactive substances with potential applications in the food and nutrition fields.

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Nanoparticles Derived from Plant Proteins for cOntrolled Release and Targeted Delivery of Therapeutics

Cited by 12 publications

References 20 publications

Self-Assembled Pea Protein Isolate Nanoparticles with Various Sizes: Explore the Formation Mechanism

Self-Assembled Pea Protein Isolate Nanoparticles with Various Sizes: Explore the Formation Mechanism

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Preparation, Characteristics, and Advantages of Plant Protein-Based Bioactive Molecule Delivery Systems

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