Nanoparticles for delivery of agents to fetal lungs

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

“…To overcome these shortcomings, one popular strategy is investigating encapsulation systems such as polymer micelles, emulsions, nanoparticles, and liposomes . Compared with other encapsulation systems, nanoparticles exhibited the advantages of suitable particle size (10–1000 nm) and remarkable penetration ability . Recently, some natural biological macromolecular proteins such as whey protein, casein, lactoferrin, and zein have emerged as Cur-loaded protein carriers due to their nontoxicity, good biocompatibility, and biodegradability.…”

In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia

“…Though the PACE NPs used for this study have been optimized for delivery to fetal lung, there is still the potential for off-target effects due to delivery to off target tissues. 33 As this therapy is translated to larger animal models, direct intra-tracheal administration could be considered to minimize off-target delivery; intratracheal PACE vehicle delivery is well tolerated in adult animals. 47 We have demonstrated that miR200b delivery induces epigenetic changes in the TGFβ pathway, but it also impacts other signal transduction pathways; further study is warranted before translation to larger animal models.…”

“…19,30 Polymeric nanoparticles (NPs) can be used for the sustained delivery of drugs, are non-toxic with a low side effect profile, and can be optimized to target fetal lung. [31][32][33] We have recently demonstrated that polymeric NPs can safely be used to deliver editing reagents in the form of peptide nucleic acids (PNAs) and donor DNAs in utero to correct a disease-causing mutation in the β-globin gene in a mouse model of human β-thalassemia. 34 Optimization for delivery to fetal lung demonstrated that intravenous delivery led to improved lung delivery over intraamniotic delivery, and that cationic poly(amine-co-ester) (PACE) nanoparticles (NPs) were delivered most efficiently to fetal lung.…”

“…34 Optimization for delivery to fetal lung demonstrated that intravenous delivery led to improved lung delivery over intraamniotic delivery, and that cationic poly(amine-co-ester) (PACE) nanoparticles (NPs) were delivered most efficiently to fetal lung. 33 Here, we sought to deliver miR200b in utero using PACE NPs to treat a rat model of CDH.…”

The Current State and Future of Fetal Therapies

“…Novel in utero treatments are under active investigation for these and many other genetic diseases using hematopoietic stem cells, enzyme replacement therapy, antisense oligonucleotides, cellular pathway inhibitors, nanoparticles, adeno-associated virus vector, and many other biotechnologies. 6,[16][17][18][19][20][21][22][23] Delivery of such therapies has been accomplished through minimally invasive methods that most commonly access the umbilical vein, amniotic fluid, or peritoneal cavity of the fetus. Therapies delivered through the amniotic fluid can access the fetal skin and pulmonary epithelium, and those delivered through the umbilical vein are systemically distributed.…”