Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities

Ramalho, Maria João; Coelho, Manuel A. N.; Pereira, Maria do Carmo

doi:10.5772/64516

Cited by 14 publications

(20 citation statements)

References 43 publications

(116 reference statements)

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“…Thus, a potential new method such as using nanotechnologies to deliver the optimal amount of vitamin D either by incorporating into foods or therapies to enhance vitamin D bioavailability and effectiveness and overcome some of the drawbacks of the traditional way of administration. 60 We suggest that acute administration of 25(OH)D, or 1,25(OH) 2 D for admitted ACS patients in large interventional randomized clinically controlled trials might improve patients' outcomes. However, further factors should be considered with supplementation of vitamin D. Those include but are not limited to parathormone, phosphate, renin, and fibroblast growth factor.…”

Section: Future Research Perspectivesmentioning

confidence: 95%

Vitamin D and Its Metabolites Deficiency in Acute Coronary Syndrome Patients Undergoing Coronary Angiography: A Case–Control Study

Ismail¹,

Algrafi²,

Amoudi

et al. 2021

VHRM

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Background Vitamin D deficiency is considered an emerging health problem that affects at least one billion patients worldwide. Calcitriol 1,25(OH) 2 D 3 has several systemic effects, including anti-inflammatory, anti-thrombotic and anti-atherosclerotic impacts that explain its cardioprotective effects. The precise association between vitamin D and its metabolites and the value of supplements in acute coronary syndrome (ACS) is still controversial. This study aims to search the association between vitamin D 2 , D 3 , and metabolites and ACS in patients undergoing coronary angiography. Materials and Methods This was a case–control study on 73 consecutive adult patients with ACS undergoing coronary angiography compared to 50 controls without coronary artery disease and matched for age and sex from June 2019 till July 2019. Echocardiography and coronary angiography were done for all cases. Plasma vitamin D and its metabolites were measured at admission for all participants along with chemistry profiles. Results Vitamin D and its metabolites were statistically significantly lower in ACS patients than the controls. Multivariate regression analysis revealed that low levels of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH) 2 D) significantly predicted ACS occurrence; the other significant predictors were high systolic blood pressure (BP), high total cholesterol, and low high-density lipoprotein-cholesterol. Interestingly, vitamin D 2 and D 3 did not significantly predict ACS (p>0.05). We did not find a statistically significant association between the number of affected coronary vessels and vitamin D metabolites. Moreover, there was no statistically significant correlation between vitamin D and its metabolites and left ventricular ejection fraction measured by echocardiography. Conclusion There was a strong association between vitamin D and all its metabolites with ACS. Significantly, low 25(OH)D and 1,25(OH) 2 D predicted ACS, but vitamin D 2 and D 3 did not. Large randomized controlled trials are needed to verify the beneficial values of vitamin D supplementation in ACS patients.

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Section: Future Research Perspectivesmentioning

confidence: 95%

Vitamin D and Its Metabolites Deficiency in Acute Coronary Syndrome Patients Undergoing Coronary Angiography: A Case–Control Study

Ismail¹,

Algrafi²,

Amoudi

et al. 2021

VHRM

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“…Other vitamin with reported beneficial effects for AD, is vitamin D. Adding to several benefits of vitamin D [87], its therapeutic effect in AD has also been studied in last years. Although the major source of vitamin D is sunlight exposure (vitamin D 3 , Figure 2C) [88], around 20% can be obtained from food, including fatty fish and fish-liver oils (vitamin D 2 , Figure 2D) [89]. In vivo studies revealed that vitamin D is an anti-inflammatory compound [90] with the ability to inhibit the activity of β and γ-secretases, reducing the Aβ production and amyloid plaques and to increase the Aβ degradation [91].…”

Section: Natural Compounds In Clinical Trials and Their Effects On Admentioning

confidence: 99%

Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

Andrade

Ramalho

Loureiro

et al. 2019

IJMS

183

111

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Alzheimer’s Disease (AD) is a neurodegenerative disorder related with the increase of age and it is the main cause of dementia in the world. AD affects cognitive functions, such as memory, with an intensity that leads to several functional losses. The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive research on this disease, only a few drugs able to delay the progression of the disease are currently available. In the last years, several compounds with pharmacological activities isolated from plants, animals and microorganisms, revealed to have beneficial effects for the treatment of AD, targeting different pathological mechanisms. Thus, a wide range of natural compounds may play a relevant role in the prevention of AD and have proven to be efficient in different preclinical and clinical studies. This work aims to review the natural compounds that until this date were described as having significant benefits for this neurological disease, focusing on studies that present clinical trials.

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“…It is a worry for public health and has several acute and chronic impacts. It results from wrong lifestyle starting in predominance obesity and inadequate sun exposure [18].…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Nutritional Considerations of Vitamin D Deficiency and Strategies of Food Fortification

Khatib¹,

Shahine²

2020

Vitamin D Deficiency

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Vitamins and minerals are crucial for human health. Any deficiency can lead to major diseases; however, the most prevalent one is the vitamin D deficiency. Due to its high risk in the Middle East and Lebanon, besides its major effects, solutions to decrease this deficiency are taken nowadays. Vitamin D food fortification is the most popular solution taken now. Liposomes showed highest efficiency in vitamin D fortification. However, a study must be done in order to deduce the amounts needed in the targeted population. Therefore, before fortification starts, FDA regulations must be reviewed. Several foods succeeded in fortification with vitamin D and increasing its levels such as milk and cheddar cheese. Stability and flavors showed good results over fortification, while according to the odor, water sources showed more aroma depth than oil sources. The AOAC methods for vitamin D amount in fortified foods must be applied. Dietary 25(OH)D3 was 7.14-fold more effective at raising serum 25(OH)D than dietary vitamin D3.

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Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities

Cited by 14 publications

References 43 publications

Vitamin D and Its Metabolites Deficiency in Acute Coronary Syndrome Patients Undergoing Coronary Angiography: A Case–Control Study

Vitamin D and Its Metabolites Deficiency in Acute Coronary Syndrome Patients Undergoing Coronary Angiography: A Case–Control Study

Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

Nutritional Considerations of Vitamin D Deficiency and Strategies of Food Fortification

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