Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng, Wei; Zhou, Qihui; Yuan, Cheng

doi:10.1155/2021/9977131

Cited by 42 publications

(28 citation statements)

References 124 publications

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“…Taking advantage of their unique (bio)physicochemical characteristics, such as small size (100–200 nm) and optimized surface potential (negative or neutral), NPs can enhance the accumulation of anti-cancer drugs in cancers and reduce their side effects [ 14 ]. Compared with ONPs, INPs possess unique optical, electric, and magnetic characteristics, making them have a promising application prospect in tumor diagnosis and treatment [ 15 – 21 ]. However, the clinical application of INPs remains a considerable challenge because of their limited biocompatibility and targeting ability.…”

Section: Introductionmentioning

confidence: 99%

Cell membrane-camouflaged inorganic nanoparticles for cancer therapy

et al. 2022

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Inorganic nanoparticles (INPs) have been paid great attention in the field of oncology in recent past years since they have enormous potential in drug delivery, gene delivery, photodynamic therapy (PDT), photothermal therapy (PTT), bio-imaging, driven motion, etc. To overcome the innate limitations of the conventional INPs, such as fast elimination by the immune system, low accumulation in tumor sites, and severe toxicity to the organism, great efforts have recently been made to modify naked INPs, facilitating their clinical application. Taking inspiration from nature, considerable researchers have exploited cell membrane-camouflaged INPs (CMCINPs) by coating various cell membranes onto INPs. CMCINPs naturally inherit the surface adhesive molecules, receptors, and functional proteins from the original cell membrane, making them versatile as the natural cells. In order to give a timely and representative review on this rapidly developing research subject, we highlighted recent advances in CMCINPs with superior unique merits of various INPs and natural cell membranes for cancer therapy applications. The opportunity and obstacles of CMCINPs for clinical translation were also discussed. The review is expected to assist researchers in better eliciting the effect of CMCINPs for the management of tumors and may catalyze breakthroughs in this area. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Cell membrane-camouflaged inorganic nanoparticles for cancer therapy

et al. 2022

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“…NPs usually include liposomes, dendrimers, gold NPs, magnetic NPs, quantum dots, polymeric NPs, etc., Nanomaterials serve as carriers for drug delivery. The unique structure of NPs can be used to deliver fluorescent dyes, chemotherapy drugs, photosensitisers or other biological materials, overcoming the limitations traditional diagnostic and therapeutic processes ( Zheng et al, 2021 ). Due to the leaky vasculatures surrounding fast-growing cancer tissues, NPs carrying anticancer agents can be absorbed by tumour cells through the enhanced permeability and retention (EPR) effects, resulting in local accumulation and cytotoxicity of the tumour cells ( Nakamura et al, 2016 ; Greish, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Advanced Polymeric Nanoagents for Oral Cancer Theranostics: A Mini Review

Zhang

Nie

et al. 2022

Front. Chem.

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Oral cancer is one of the most common tumours in the world threatening human life and health. The 5-years survival rate of patients with oral cancer has not been improved significantly for many years. The existing clinical diagnostic methods rarely achieve early diagnosis due to deficiencies such as lack of sensitivity. Most of the patients have progressed to the advanced stages when oral cancer is detected. Unfortunately, the traditional treatment methods are usually ineffective at this stage. Therefore, there is an urgent need for more effective and precise techniques for early diagnosis and effective treatment of oral cancer. In recent decades, nanomedicine has been a novel diagnostic and therapeutic platform for various diseases, especially cancer. The synthesis and application of various nanoagents have emerged at the right moment. Among them, polymer nanoagents have unique advantages, such as good stability, high biosafety and high drug loading, showing great potential in the early accurate diagnosis and treatment of tumours. In this review, we focus on the application of advanced polymeric nanoagents in both the diagnosis and treatment of oral cancer. Then, the future therapy strategies and trends for polymeric nanoagents applied to oral cancer are discussed, with the hope that more advanced nanomedical technology will be applied to oral cancer research and promote the development of stomatology.

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“…Under pathological conditions, the delicate balance will be disturbed and usually lead to ROS accumulation and oxidative stress ( Aggarwal et al, 2019 ). In oncology, evidence has linked the increased ROS level with cancer initiation, progression, angiogenesis, and metastasis ( Moldogazieva et al, 2018 ), making ROS elimination a promising strategy for controlling the disease ( Zheng et al, 2021 ). Paradoxically, ROS can also be beneficial for tumor suppression.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword

Wang

Liu

Jiang

et al. 2021

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their multiple roles, which may vary with their concentration, location and the immune microenvironment they are in. Here, we have reviewed the reported effects of ROS on macrophage polarization, immune checkpoint blocking (ICB) therapy, T cell activation and expansion, as well as the induction of immunogenic cell death. A majority of reports are indicating detrimental effects of ROS, but it is unadvisable to simply scavenge them because of their pleiotropic effects in most occasions (except in T cell activation and expansion where ROS are generally undesirable). Therefore, clinical success will need a clearer illustration of their multi-faced functions, as well as more advanced technologies to tune ROS level with high spatiotemporal control and species-specificity. With such progresses, the efficacy of current immunotherapies will be greatly improved by combining with ROS-targeted therapies.

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Nanoparticles for Oral Cancer Diagnosis and Therapy

Cited by 42 publications

References 124 publications

Cell membrane-camouflaged inorganic nanoparticles for cancer therapy

Cell membrane-camouflaged inorganic nanoparticles for cancer therapy

Advanced Polymeric Nanoagents for Oral Cancer Theranostics: A Mini Review

Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword

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