Nanoparticles in biomedical applications

McNamara, Karrina; Tofail, Syed A. M.

doi:10.1080/23746149.2016.1254570

Cited by 321 publications

(286 citation statements)

References 223 publications

(354 reference statements)

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“…Metallic, bimetallic, and metal oxide nanoparticles have seen extensive use in biomedical applications [154]. The use of bimetallic nanoparticles for biological applications is focused on exploiting their optical or magnetic properties.…”

Section: Biological Applicationsmentioning

confidence: 99%

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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Metal nanoparticles are extensively studied due to their unique chemical and physical properties, which differ from the properties of their respective bulk materials. Likewise, the properties of heterogeneous bimetallic structures are far more attractive than those of single-component nanoparticles. For example, the incorporation of a second metal into a nanoparticle structure influences and can potentially enhance the optical/plasmonic and magnetic properties of the material. This review focuses on the enhanced optical/plasmonic and magnetic properties offered by bimetallic nanoparticles and their corresponding impact on biological applications. In this review, we summarize the predominant structures of bimetallic nanoparticles, outline their synthesis methods, and highlight their use in biological applications, both diagnostic and therapeutic, which are dictated by their various optical/plasmonic and magnetic properties.

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Section: Biological Applicationsmentioning

confidence: 99%

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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“…Nanoparticles are defined as colloidal materials with subcellular/sub‐micrometer sizes ranging from 1 to 1000 nm . In recent decades, these systems have attracted significant interest due to their numerous biomedical applications ranging from controlled delivery of hydrophilic/hydrophobic therapeutics, to multimodal bioimaging, biosensing and diagnostics .…”

Section: Cell–biomaterials Assembliesmentioning

confidence: 99%

Advanced Bottom‐Up Engineering of Living Architectures

et al. 2019

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Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.

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“…MRI is not limited by the depth of the implant in the tissue and delivers reasonably high spatial resolution, while preclinical experiments are easily transferable to clinical practice . Although its sensitivity is low compared to PET, it can be enhanced using suitably designed labels such as nanoparticle labels, which can be also utilized as drug delivery or therapy systems …”

Section: Introductionmentioning

confidence: 99%

Manganese‐Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo

et al. 2019

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Manganese‐zinc ferrite nanoparticles were synthesized by using a hydrothermal treatment, coated with silica, and then tested as efficient cellular labels for cell tracking, using magnetic resonance imaging (MRI) in vivo. A toxicity study was performed on rat mesenchymal stem cells and C6 glioblastoma cells. Adverse effects on viability and cell proliferation were observed at the highest concentration (0.55 mM) only; cell viability was not compromised at lower concentrations. Nanoparticle internalization was confirmed by transmission electron microscopy. The particles were found in membranous vesicles inside the cytoplasm. Although the metal content (0.42 pg Fe/cell) was lower compared to commercially available iron oxide nanoparticles, labeled cells reached a comparable relaxation rate R 2, owing to higher nanoparticle relaxivity. Cells from transgenic luciferase‐positive rats were used for in vivo experiments. Labeled cells were transplanted into the muscles of non‐bioluminescent rats and visualized by MRI. The cells produced a distinct hypointense signal in T2‐ or T2*‐weighted MR images in vivo. Cell viability in vivo was verified by bioluminescence.

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Nanoparticles in biomedical applications

Cited by 321 publications

References 223 publications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Advanced Bottom‐Up Engineering of Living Architectures

Manganese‐Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo

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