Nanoparticles in Drug Delivery and Cancer Therapy: The Giant Rats Tail

Prabhu, Venugopal Vinod; Uzzaman, Siddik; Grace, V. M. Berlin; Guruvayoorappan, Chandrasekharan

doi:10.4236/jct.2011.23045

Cited by 41 publications

(19 citation statements)

References 96 publications

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“…For the past few decades, nanoparticles of silver have been gaining much attention and being used in almost every field, including medicine (Nithya and Ragunathan 2014;Knetsch and Koole 2011), catalysis (Venkatesham et al 2012), bio sensing (Priyanka et al 2013;Doria et al 2012;Zhu et al 2009), drug delivery (Soumya and Gayatri Hela 2013;Prabhu and Uzzaman 2011;Diaz and VivasMejia 2013), electronics Lu 2007;Karni et al 2012), textile (Xue et al 2012), photonics (Shen et al 2000), optical sensor (Pandey et al 2012), nonlinear optical properties (Ye et al 2009;Vasireddy and Paul 2012), water treatment (Monyatsi et al 2012;Ebeling et al 2013), pigments, photographic, bactericide (Kim et al 2007;Govarthanan et al 2014;Rajawat and Qureshi 2012;Li et al 2013;Yasina et al 2013), anticancer agent (Devi and Bhimba 2012;Mukherjee et al 2014;Sulaiman et al 2013;Nazir et al 2011), wound treatment (Habiboallah et al 2014, conductive composites (Pandey et al 2012), etc.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical synthesis, characterisation and phytogenic properties of silver nanoparticles

Singaravelan¹,

Alwar²

2015

Appl Nanosci

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This work exemplifies a simple and rapid method for the synthesis of silver nanodendrite with a novel electrochemical technique. The antibacterial activity of these silver nanoparticles (Ag NPs) against pathogenic bacteria was investigated along with the routine study of optical and spectral characterisation. The optical properties of the silver nanoparticles were characterised by diffuse reflectance spectroscopy. The optical band gap energy of the electrodeposited Ag NPs was determined from the diffuse reflectance using Kubelka-Munk formula. X-ray diffraction (XRD) studies were carried out to determine the crystalline nature of the silver nanoparticles which confirmed the formation of silver nanocrystals. The XRD pattern revealed that the electrodeposited Ag NPs were in the cubic geometry with dendrite preponderance. The average particle size and the peak broadening were deliberated using Debye-Scherrer equation and lattice strain due to the peak broadening was studied using Williamson-Hall method. Surface morphology of the Ag NPs was characterised by high-resolution scanning electron microscope and the results showed the high degree of aggregation in the particles. The antibacterial activity of the Ag NPs was evaluated and showed unprecedented level antibacterial activity against multidrug resistant strains such as Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia and Escherichia coli in combination with Streptomycin.

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Section: Introductionmentioning

confidence: 99%

Electrochemical synthesis, characterisation and phytogenic properties of silver nanoparticles

Singaravelan¹,

Alwar²

2015

Appl Nanosci

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“…Nanoparticles are small molecules that can be characterized as a whole unit in term of transport and properties (Tiwari et al, 2012;Prabhu et al, 2011). Nanoparticles in research filed has generated a passionate interest in scientists with the discovery of lipid based nanoparticles by Professor A.D. Bangham of the United Kingdom in 1960 (Puri et al, 2009).…”

Section: Nanotechnology In Cancer Biologymentioning

confidence: 99%

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

Weerathunga¹,

Silva²

2017

International Conference on Bioscience and Biotechnology

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Cancer is a highly heterogeneous and complex disease condition to understand because of its cellular and physiological systems. The most common cancer treatments are chemotherapy, radiotherapy and surgical excision. Out of them chemotherapy remains as the most widely used anti-cancer therapy. But unfortunately chemotherapy has plenty of drawbacks when considering its action on cancerous cells. Many chemotherapeutic drugs are highly toxic, not specific, poorly selective and less soluble because of these incidents cancer patients have severe side effects such as alopecia, renal failures, cardiac failures and etc. In order to overcome these problems in nanotechnology based targeted drug delivery system was introduced. Nanotechnology is a rapidly growing files which promote novel methods in cancer diagnosis, treatments and prognosis. In targeted drug delivery system use differently synthesized nanoparticles to reduce the drawbacks of chemotherapy. Nanoparticles such as liposomes, carbon nanotubes, virus mediated nanoparticles and nanodiamonds are some of the nanoparticles which are being discussed in this article. By using nanoparticles many of the drawbacks in conventional chemotherapy can be altered for an example by using surface functionalized nanoparticles chemotherapeutic drugs can be loaded into the particle and easily can be delivered to the exact tumor site without harming the non-cancerous cells while increasing the halflife of the drug. Likewise there are many advantages in nanotaenology based targeted drug delivery system over the conventional chemotherapy which will give a new ray of hope towards cancer patients to have a quality life.

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“…In-vitro drug release kinetics studies of gelatin nanoparticles STABILITY STUDIES [21] A physical stability test was carried out to investigate the leaching of drug from gelatin during storage. The samples were sealed in glass vials and stored at two different temperature conditions, i.e., Refrigeration temperature (4-8 0 C) and room temp.…”

Section: Sem Image Of Rifabutin Loaded Gelatin Nanoparticlesmentioning

confidence: 99%

Develpoment of Novel Nanoparticulate Drug Delivery System of Rifabutin

Kumari¹

2017

WJPPS

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Nanotechnology has the potential to offer solutions to these current obstacles in cancer therapies, because of its unique size and large surface-to-volume ratios. Nanoparticles may have properties of selfassembly, stability, specificity, drug encapsulation and biocompatibility as a result of their material composition. The multidisciplinary field of nanotechnology's application for discovering new molecules and manipulating those available naturally could be excited in its potential to improve health care. Nanotechnology is definitely a medical boon for diagnosis, treatment and prevention of various diseases including cancer. It supports and ex-pands the scientific advances in genomic and proteomics and builds on our understanding of the molecular under-pinnings of cancer and its treatment. Encapsulation of rifabutin in Gelatin nanoparticles enables development of the intravenous formulation of this poorly soluble antituberculosis antibiotic. After oral administration, the nanoparticle-based formulation of rifabut in produced a 2-fold increase in bioavailability, as compared to the parent drug the present study work on Development of Novel Nanoparticulate Drug Delivery System of Rifabutin.

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Nanoparticles in Drug Delivery and Cancer Therapy: The Giant Rats Tail

Abstract: ABSTRACT

Cited by 41 publications

References 96 publications

Electrochemical synthesis, characterisation and phytogenic properties of silver nanoparticles

Electrochemical synthesis, characterisation and phytogenic properties of silver nanoparticles

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

Develpoment of Novel Nanoparticulate Drug Delivery System of Rifabutin

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