Nanoparticles in Drug Delivery: From History to Therapeutic Applications

Abstract

Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating nanocarriers. This paper reviews the various conventionally used and current used carriage system to deliver drugs. Due to numerous drawbacks of conventional DDSs, nanocarriers have gained immense interest. Nanocarriers like polymeric nanoparticles, mesoporous nanoparticles, nanomaterials, carbon nanotubes, dendrimers, liposomes, metallic nanoparticles, nanomedicine, and engineered nanomaterials are used as carriage systems for targeted delivery at specific sites of affected areas in the body. Nanomedicine has rapidly grown to treat certain diseases like brain cancer, lung cancer, breast cancer, cardiovascular diseases, and many others. These nanomedicines can improve drug bioavailability and drug absorption time, reduce release time, eliminate drug aggregation, and enhance drug solubility in the blood. Nanomedicine has introduced a new era for drug carriage by refining the therapeutic directories of the energetic pharmaceutical elements engineered within nanoparticles. In this context, the vital information on engineered nanoparticles was reviewed and conferred towards the role in drug carriage systems to treat many ailments. All these nanocarriers were tested in vitro and in vivo. In the coming years, nanomedicines can improve human health more effectively by adding more advanced techniques into the drug delivery system.

Review On Targeted Drug Delivery System And Its Carriers As Drug Targeted To A Specific Organ

“…Nanotechnology can deliver drug molecules to target sites without damaging healthy cells.Nanoparticles have specific material characteristics because of Sub microscopic size and additionally provide practical implementations in a extensive variety of fields such as engineering, drug delivery, nanomedicine, environmental indemnification, and catalysis, as well as target diseases including cancer and cardiovascular diseases (CVD),skin diseases, liver diseases, and many others. (22). Nanoparticles can mimic or regulate biological processes (e.g., infection, tissue engineering, , etc.).…”

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

“…Moreover, NPs are being employed as imaging agents for lung cancer treatment. [8][9][10] By creating NPs that are highly visible on imaging scans such as computed tomography (CT) and magnetic resonance imaging (MRI), clinicians can monitor treatment progress and trace NP mobility in the lungs. However, this article does not delve into the application of these NP types.…”

Gold Nanoparticles Induced Size Dependent Cytotoxicity on Human Alveolar Adenocarcinoma Cells by Inhibiting the Ubiquitin Proteasome System

“…Additionally, AuNPs can be used as drug carriers to improve drug delivery and reduce side effects through more effective targeting [ 5 , 6 ]. Recent advances in AuNPs development have shown that they may also be ideal candidates for viral targeting and diagnosis [ 7 , 8 , 9 ] and may be used as stand-alone entities or carriers for other drugs or vaccine delivery [ 10 , 11 , 12 ].…”