Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations

Hofmann-Amtenbrink, Margarethe; Grainger, David W.; Hofmann, Heinrich

doi:10.1016/j.nano.2015.05.005

Cited by 195 publications

(129 citation statements)

References 10 publications

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“…44 It is well known that an excessive dose of silver NPs or CHX can trigger cell death, leading to unwanted side effects. 45,46 We proposed that MSNs in our system are capable of reducing the silver ions release and possessing pH-selective CHX release in normal cells, resulting in lower toxicity.…”

Section: Cytotoxicity Of Ag-msns@chxmentioning

confidence: 99%

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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Combination of chlorhexidine (CHX) and silver ions could engender synergistic bactericidal effect and improve the bactericidal efficacy. It is highly desired to develop an efficient carrier for the antiseptics codelivery targeting infection foci with acidic microenvironment. In this work, monodisperse mesoporous silica nanoparticle (MSN) nanospheres were successfully developed as an ideal carrier for CHX and nanosilver codelivery through a facile and environmentally friendly method. The CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) exhibited a pH-responsive release manner of CHX and silver ions simultaneously, leading to synergistically antibacterial effect against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli . Moreover, the effective antibacterial concentration of Ag-MSNs@CHX showed less cytotoxicity on normal cells. Given their synergistically bactericidal ability and good biocompatibility, these nanoantiseptics might have effective and broad clinical applications for bacterial infections.

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Section: Cytotoxicity Of Ag-msns@chxmentioning

confidence: 99%

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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“…Engineered nanoparticles (NPs) and predominantly inorganic NPs can affect the cell viability as shown in various studies (Ahlberg et al, 2014;Hofmann-Amtenbrink et al, 2015). By contrast, polymeric particles can be adjusted to their field of operation and can be loaded for drug delivery (Mak et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

et al. 2017

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(2017) Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes, Nanotoxicology, 11:2, 267-277, DOI: 10.1080/17435390.2017 ABSTRACTNovel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery. ARTICLE HISTORY

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“…This is due to both their potential medical application of nanoparticles [5][6][7][8][9][10][11] and danger for humans [12][13][14][15]. The promising future of biomedical application and the potential danger of nanoparticles are to a considerable extent predicated by their ability to penetrate through cell and intercellular membranes and, therefore, spread throughout the organism.…”

Section: Introductionmentioning

confidence: 99%

Biological effect of zirconium dioxide-based nanoparticles

Almjasheva¹,

Гарабаджиу²,

Kozina³

et al. 2017

Nanosystems: Phys. Chem. Math.

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Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations

Cited by 195 publications

References 10 publications

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

Biological effect of zirconium dioxide-based nanoparticles

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