Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal

Kanwar, Jagat R.; Sun, Xueying; Punj, Vasu; Sriramoju, Bhasker; Mohan, Rajiv R.; Zhou, Shu‐Feng; Chauhan, Ankur; Kanwar, Rupinder K.

doi:10.1016/j.nano.2011.08.006

Cited by 126 publications

(69 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bu Aβ birikmesi Alzheimer'ın sebebi olarak görül-mektedir. 38 Güncel gelişmeler çinko ve bakır gibi metal iyonlarının Aβ agregasyonunda önemli bir rol oynadığını göstermiştir. Aβ, histidin kalıntıları-nın aracılık ettiği, çinko ve bakıra selektif yüksek ve düşük afiniteli bağlama bölgeleri bulundurmaktadır.…”

Section: Alzhei̇mer Hastaliğiunclassified

“…Lenfositlerin SSS içine girişi otoimmün ve inflamatuar reaksiyonlara neden olmakta ve lenfositler seçici olarak miyelin üretimini sağlayan oligodendrositleri yok ederek demiyelinizasyon olayına aracılık etmektedir. 38 Çoğu MS tedavisi, hayvanlarda MS modeli olarak kullanılan deneysel otoimmün ensefalomiyelit [experimental autoimmure encephalomyelitis (EAE)] üzerine geliştirilmiştir. Bu modelde hastalığı ilerleten temel mekanizma miyeline karşı verilen inflamatuar tepkidir.…”

Section: Multi̇pl Sklerozunclassified

See 1 more Smart Citation

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Arısoy¹,

Sayiner²,

Çomoğlu³

2017

Turkiye Klinikleri J Pharm Sci

View full text Add to dashboard Cite

Section: Alzhei̇mer Hastaliğiunclassified

Section: Multi̇pl Sklerozunclassified

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Arısoy¹,

Sayiner²,

Çomoğlu³

2017

Turkiye Klinikleri J Pharm Sci

View full text Add to dashboard Cite

“…42 Recent research shows that the nanomedicine required for neurodegenerative pathologies is much less than that needed for cancer and infectious diseases. 43 Thus, emerging nanotechnologies for production of neurotrophin delivery systems are promising in terms of their ability to activate neurotrophin signaling for neuroprotection and neuroregeneration. 44 Neurotrophins are proteins that were initially recognized as being factors related to the survival of sympathetic and sensory neurons.…”

Section: Cnts In Drug Deliverymentioning

confidence: 99%

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

John¹,

Subramanian²,

Vellayappan³

et al. 2015

IJN

View full text Add to dashboard Cite

Neuroregeneration is the regrowth or repair of nervous tissues, cells, or cell products involved in neurodegeneration and inflammatory diseases of the nervous system like Alzheimer’s disease and Parkinson’s disease. Nowadays, application of nanotechnology is commonly used in developing nanomedicines to advance pharmacokinetics and drug delivery exclusively for central nervous system pathologies. In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons. Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits. This review describes the role of carbon nanotubes and graphene in neuroregeneration. In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

show abstract

“…A variety of malignant brain tumors exist, including gliomas, medulloblastomas, and primary central nervous system lymphomas, as well as tumors that have metastasized to the brain. 110 Age and gender seem to be associated with certain types of central nervous system malignancy. For instance, malignant astrocytoma and glioblastoma multiforme are the most commonly identified primary brain tumors in male adults, whereas astrocytoma, medulloblastoma, and glioblastoma are predominantly found in children.…”

Section: Neuro Oncologymentioning

confidence: 99%

Neurological disorders and therapeutics targeted to surmount the blood–brain barrier

Kanwar¹,

Sriramoju²,

Kanwar³

2012

IJN

View full text Add to dashboard Cite

Abstract:We are now in an aging population, so neurological disorders, particularly the neurodegenerative diseases, are becoming more prevalent in society. As per the epidemiological studies, Europe alone suffers 35% of the burden, indicating an alarming rate of disease progression. Further, treatment for these disorders is a challenging area due to the presence of the tightly regulated blood-brain barrier and its unique ability to protect the brain from xenobiotics. Conventional therapeutics, although effective, remain critically below levels of optimum therapeutic efficacy. Hence, methods to overcome the blood-brain barrier are currently a focus of research. Nanotechnological applications are gaining paramount importance in addressing this question, and yielding some promising results. This review addresses the pathophysiology of the more common neurological disorders and novel drug candidates, along with targeted nanoparticle applications for brain delivery.

show abstract

Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal

Cited by 126 publications

References 118 publications

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

Neurological disorders and therapeutics targeted to surmount the blood–brain barrier

Contact Info

Product

Resources

About

Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal

Cited by 126 publications

References 118 publications

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

Neurological disorders and therapeutics targeted to surmount the blood&ndash;brain barrier

Contact Info

Product

Resources

About

Neurological disorders and therapeutics targeted to surmount the blood–brain barrier